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Neoechinulin A {[allProObj[0].p_purity_real_show]}

货号:A705666

Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.

Neoechinulin A 化学结构 CAS号:51551-29-2
Neoechinulin A 化学结构
CAS号:51551-29-2
Neoechinulin A 3D分子结构
CAS号:51551-29-2
Neoechinulin A 化学结构 CAS号:51551-29-2
Neoechinulin A 3D分子结构 CAS号:51551-29-2
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Neoechinulin A 纯度/质量文件 产品仅供科研

货号:A705666 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 p38 MAPK p38α p38β 其他靶点 纯度
BMS-582949 +++

p38 MAPK, IC50: 13 nM

98%
SB 203580 99%+
Pexmetinib Tie-2 99%+
Skepinone-L ++++

p38α, IC50: 5 nM

98%
Doramapimod ++++

p38α, Kd: 0.1 nM

p38α, IC50: 38 nM

99%+
VX-702 99%+
Ralimetinib dimesylate ++++

p38α, IC50: 7 nM

98%
SB 202190 ++

p38α, IC50: 50 nM

++

p38β, IC50: 100 nM

99%+
Losmapimod ++++

p38α, pKi: 8.1

+++

p38β, pKi: 7.6

99%+
Neflamapimod +++

p38α, IC50: 10 nM

+

p38β, IC50: 220 nM

99%+
PH-797804 ++

p38α, IC50: 26 nM

+

p38β, IC50: 102 nM

98%
TAK-715 ++++

p38α, IC50: 7.1 nM

+

p38β, IC50: 0.20 μM

99%+
SB 239063 ++

p38α, IC50: 44 nM

++

p38β, IC50: 44 nM

99%+
Pamapimod +++

p38α, IC50: 0.014 μM

+

p38β, IC50: 0.48 μM

98%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 HIV Protease HIV-1 caspid 其他靶点 纯度
Dextran sulfate sodium, mw 40,000 M.W 40000
Vicriviroc maleate 98+%
Rosamultin 97%
Darunavir 98%
Lopinavir ++++

HIV protease, Ki: 1.3 pM

99+%
Chloroquine Autophagy 95%
Amprenavir +

HIV protease, IC50: 14.6 ng/mL

PXR 99%+
NBD-556 99%+
Nelfinavir Mesylate +++

HIV protease, Ki: 2 nM

99%+
Atazanavir Sulfate 98%
Limonin 98%
Saquinavir ++

HIV proteinase, IC50: 2.7 nM

98%
Ritonavir 98%
Azvudine 98%
Lenacapavir ++++

HIV-1 capsid, EC50: 0.1 nM

97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Neoechinulin A 生物活性

描述 Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.

Neoechinulin A 参考文献

[1]Kim KS, Cui X, et al. Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-кB and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules. 2013 Oct 25;18(11):13245-59.

[2]Dewapriya P, Li YX, et al. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. Neurotoxicology. 2013 Mar;35:30-40.

Neoechinulin A 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.09mL

0.62mL

0.31mL

15.46mL

3.09mL

1.55mL

30.92mL

6.18mL

3.09mL

Neoechinulin A 技术信息

CAS号51551-29-2
分子式C19H21N3O2
分子量 323.389
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,2-8°C

溶解度
动物实验配方
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