Nelfinavir Mesylate | AG 1343 Mesylate | HIV-1 Protease Inhibitor

规格	价格	会员价	库存	数量
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产品名称	HIV Protease ↓ ↑	HIV-1 caspid ↓ ↑	其他靶点	纯度
Dextran sulfate sodium, mw 40,000	✔			M.W 40000
Vicriviroc maleate	✔			98+%
Rosamultin	✔			97%
Darunavir	✔			98%
Lopinavir	++++ HIV protease, Ki: 1.3 pM			99+%
Chloroquine	✔		Autophagy	95%
Amprenavir	+ HIV protease, IC50: 14.6 ng/mL		PXR	99%+
NBD-556	✔			99%+
Nelfinavir Mesylate	+++ HIV protease, Ki: 2 nM			99%+
Atazanavir Sulfate	✔			98%
Limonin	✔			98%
Saquinavir	++ HIV proteinase, IC50: 2.7 nM			98%
Ritonavir	✔			98%
Azvudine	✔			98%
Lenacapavir		++++ HIV-1 capsid, EC50: 0.1 nM		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00002411	HIV Infections	Not Applicable	Completed	-	-
NCT00000895	Mycobacterium Avium-intracellu... 展开 >>lare Infection HIV Infections 收起 <<	Not Applicable	Completed	-	-
NCT00122590	HIV Infections	Not Applicable	Terminated	-	France ... 展开 >> Service de Medecine Interne Hopital Cochin Paris, France, 75014 收起 <<
NCT00002240	HIV Infections	Phase 2	Completed	-	United States, Alabama ... 展开 >> Clinsites / Sorra Research Ctr Birmingham, Alabama, United States, 35203 Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California UCSD Treatment Ctr San Diego, California, United States, 92103 UCSF - San Francisco Gen Hosp San Francisco, California, United States, 94110 United States, Colorado Univ of Colorado / Health Science Ctr Denver, Colorado, United States, 80262 United States, District of Columbia ViRx / Dupont Circle Physicians Group Washington, District of Columbia, United States, 20009 United States, Georgia AIDS Research Consortium of Atlanta Atlanta, Georgia, United States, 30308 United States, Illinois Rush Presbyterian - Saint Luke's Med Ctr Chicago, Illinois, United States, 60612 United States, Missouri Washington Univ School of Medicine St Louis, Missouri, United States, 63108 United States, New York Albany Med College Albany, New York, United States, 12208 Beth Israel Med Ctr New York, New York, United States, 10003 Columbia Presbyterian Med Ctr New York, New York, United States, 10032 United States, Ohio Case Western Reserve Univ Cleveland, Ohio, United States, 44106 United States, Texas Oak Lawn Physicians Group Dallas, Texas, United States, 75219 Univ of Texas Southwestern Med Ctr of Dallas Dallas, Texas, United States, 75235 Univ TX Galveston Med Branch Galveston, Texas, United States, 77555 Canada, Ontario Ottawa General Hospital Ottawa, Ontario, Canada 收起 <<
NCT00346580	Sepsis	Phase 1	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic Rochester, Minnesota, United States, 55905 收起 <<
NCT00005106	HIV Infections	Phase 4	Completed	-	-
NCT00002423	HIV Infections	Phase 2	Completed	-	United States, California ... 展开 >> Saint Francis Mem Hosp San Francisco, California, United States, 94109 United States, District of Columbia Georgetown Univ Med Ctr Washington, District of Columbia, United States, 20007 United States, Florida IDC Research Initiative Altamonte Springs, Florida, United States, 32701 United States, Maryland Natl Institute of Allergy and Infectious Diseases Bethesda, Maryland, United States, 20892 United States, Missouri Kansas City AIDS Research Consortium Kansas City, Missouri, United States, 64111 United States, New York Bentley-Salick Med Practice New York, New York, United States, 10011 United States, Oklahoma Associates in Med and Mental Health Tulsa, Oklahoma, United States, 74114 United States, Oregon Portland Veterans Adm Med Ctr / Rsch & Education Grp Portland, Oregon, United States, 972109951 收起 <<
NCT00002372	HIV Infections	Phase 1	Completed	-	United States, California ... 展开 >> Univ of California / San Diego Treatment Ctr San Diego, California, United States, 92103 ViRx Inc San Francisco, California, United States, 94109 United States, North Carolina Univ of North Carolina at Chapel Hill / Duke Univ Med Ctr Durham, North Carolina, United States, 27710 收起 <<
NCT00044837	HIV Infections	Phase 1	Terminated	-	United States, Maryland ... 展开 >> Barbara Brizz Rockville, Maryland, United States, 20852 收起 <<
NCT00002216	HIV Infections	Not Applicable	Completed	-	United States, Pennsylvania ... 展开 >> Anderson Clinical Research Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT00005002	HIV Infections	Phase 3	Unknown	-	United States, California ... 展开 >> Agouron Pharmaceuticals Inc San Diego, California, United States, 92121 收起 <<
NCT00002224	HIV Infections	Phase 3	Completed	-	-
NCT00002378	HIV Infections	Phase 3	Completed	-	-
NCT00006443	HIV Infections	Not Applicable	Completed	-	United States, Alabama ... 展开 >> Michael S. Saag Birmingham, Alabama, United States, 35294 收起 <<
NCT00006441	HIV Infections	Not Applicable	Completed	-	United States, Alabama ... 展开 >> University of Alabama- Birmingham Birmingham, Alabama, United States, 35294 United States, California Rick Hecht San Francisco, California, United States, 941102859 收起 <<
NCT00000892	HIV Infections	Not Applicable	Completed	-	-
NCT00099359	-		Completed	-	-
NCT00004583	HIV Infections	Phase 3	Completed	-	-
NCT00002397	HIV Infections ... 展开 >> AIDS-Associated Nephropathy 收起 <<	Phase 3	Completed	-	United States, New York ... 展开 >> Mount Sinai Med Ctr New York, New York, United States, 10029 收起 <<
NCT00001133	HIV Infections	Phase 1	Completed	-	United States, Alabama ... 展开 >> Alabama Therapeutics CRS Birmingham, Alabama, United States, 35294 United States, California USC CRS Los Angeles, California, United States, 900331079 Ucsf Aids Crs San Francisco, California, United States, 94110 United States, Maryland Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, New York NY Univ. HIV/AIDS CRS New York, New York, United States, 10016 United States, Ohio Univ. of Cincinnati CRS Cincinnati, Ohio, United States, 452670405 United States, Pennsylvania Pitt CRS Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT00018083	Tuberculosis ... 展开 >>HIV Infections 收起 <<	Not Applicable	Unknown	-	United States, North Carolina ... 展开 >> Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Carol D Hamilton, M.D. 919-684-3279 收起 <<
NCT00002442	HIV Infections	Phase 2	Completed	-	United States, California ... 展开 >> AIDS Healthcare Foundation Los Angeles, California, United States, 90027 Palo Alto Veterans Affairs Health Care System Palo Alto, California, United States, 94304 United States, District of Columbia Dupont Circle Physicians Group Washington, District of Columbia, United States, 200091104 United States, Florida IDC Research Initiative Altamonte Springs, Florida, United States, 32701 North Broward Hosp District Fort Lauderdale, Florida, United States, 33316 Steinhart Medical Associates Miami, Florida, United States, 33133 United States, Illinois Northwestern Univ Med School Chicago, Illinois, United States, 60611 United States, New York Saint Vincents Hosp New York, New York, United States, 10011 St Lukes - Roosevelt Hosp Ctr New York, New York, United States, 10019 United States, Pennsylvania MCP Hahnemann Univ Hosp Philadelphia, Pennsylvania, United States, 19102 United States, Texas Southwest Infectious Disease Association / PA Dallas, Texas, United States, 75225 Univ TX Galveston Med Branch Galveston, Texas, United States, 77550 收起 <<
NCT00000918	HIV Infections	Phase 2	Completed	-	-
NCT00002211	HIV Infections	Not Applicable	Completed	-	United States, New Jersey ... 展开 >> Pharmacia & Upjohn Peapack, New Jersey, United States, 07977 收起 <<
NCT00001766	HIV Infection	Phase 1	Completed	-	United States, Maryland ... 展开 >> National Institute of Allergy and Infectious Diseases (NIAID) Bethesda, Maryland, United States, 20892 收起 <<
NCT00099359	Disease Transmission, Vertical... 展开 >> Vertical Human Immunodeficiency Virus Transmission HIV Infections 收起 <<	Phase 3	Completed	-	United States, California ... 展开 >> Miller Children's Hospital Long Beach, California, United States, 90806 United States, Florida University of FL Gainesville, Florida, United States, 32610-0296 University of FL-HSC Jacksonville, Florida, United States, 32209 United States, New Jersey University Medical and Dental School of NJ-Newark Campus Newark, New Jersey, United States, 07103 United States, Texas Texas Childrens Hospital Houston, Texas, United States, 77030 Argentina Hospital I. G. A. Dr. Diego Paroissien Buenos Aires, Argentina Brazil Federal University of Minas Gerais (UFMG) Belo Horizonte, MG, Brazil, 30130-100 Universidade de Sao Paulo (USP) , MD São Paulo, Ribeirão Preto, Brazil, 14024-250 Hospital Fêmina S.A. Unidade Perinatal de Transmissão Vertical Porto Alegre, Rio Grande do Sul, Brazil, 90430001 Hospital Santa Casa (HSC) Porto Alegre, Rio Grande do Sul, Brazil, 90850 530 Hospital Nossa Senhora da Conceicao (GHC) Porto Alegre, Rio Grande do Sul, Brazil, 91350-200 Hospital dos Servidores do Estado (HSE) Rio de Janeiro, Brazil, 20221-903 Hospital Geral de Novo Iguacu Rio de Janeiro, Brazil, 26030-380 5088 - Universidade Federal de Sao Paulo (UFSP) São Paulo, Brazil, 04939-002 Puerto Rico San Juan Hospital San Juan, Puerto Rico, 00936-8344 South Africa Tygerberg Hospital Cape Town, South Africa Chris Hani Baragwanath Hospital Johannesburg, South Africa 收起 <<
NCT00051844	Human Immunodeficiency Virus	Phase 2	Completed	-	-
NCT00002176	HIV Infections	Not Applicable	Completed	-	United States, California ... 展开 >> Univ of California at San Francisco Gen Hosp San Francisco, California, United States, 94110 收起 <<
NCT00002220	HIV Infections	Phase 3	Completed	-	United States, California ... 展开 >> LAC / USC Med Ctr / Infectious Diseases Los Angeles, California, United States, 90033 United States, Connecticut Yale Univ / AIDS Clinical Trials Unit New Haven, Connecticut, United States, 06510 United States, Delaware Med Ctr of Delaware Wilmington, Delaware, United States, 19899 United States, Hawaii Hawaii AIDS Clinical Trial Unit Honolulu, Hawaii, United States, 96816 United States, Illinois Rush Presbyterian Saint Lukes Med Ctr Chicago, Illinois, United States, 606123832 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 212876220 United States, Massachusetts Massachusetts Gen Hosp Boston, Massachusetts, United States, 02114 United States, New York Columbia Presbyterian Hosp New York, New York, United States, 10032 AIDS TMT Unit / Univ Hosp Stonybrook, New York, United States, 117948153 United States, Tennessee Vanderbilt Clinic Nashville, Tennessee, United States, 37212 United States, Texas Oaklawn Physicians Group Dallas, Texas, United States, 75219 收起 <<
NCT00001087	HIV Infections	Phase 2	Completed	-	United States, Illinois ... 展开 >> Northwestern University CRS Chicago, Illinois, United States, 60611 Cook County Hosp. CORE Ctr. Chicago, Illinois, United States, 60612 Rush Univ. Med. Ctr. ACTG CRS Chicago, Illinois, United States, 60612 United States, Maryland Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, New York NY Univ. HIV/AIDS CRS New York, New York, United States Puerto Rico Puerto Rico-AIDS CRS San Juan, Puerto Rico, 009365067 收起 <<
NCT00017758	HIV Infections ... 展开 >> HIV Seronegativity Lipodystrophy 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> Stanford Univ Med Ctr Stanford, California, United States, 943055107 United States, Colorado Univ of Colorado Health Sciences Ctr Denver, Colorado, United States, 80262 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 21287 United States, Minnesota Univ of Minnesota Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington Univ / St Louis Connect Care Saint Louis, Missouri, United States, 63108 Washington Univ School of Medicine St Louis, Missouri, United States, 63108 United States, New York Univ of Rochester Medical Center Rochester, New York, United States, 14642 United States, Ohio Univ of Cincinnati Cincinnati, Ohio, United States, 452670405 United States, Pennsylvania Univ of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Washington Univ of Washington Seattle, Washington, United States, 98104 收起 <<
NCT00002380	HIV Infections	Phase 1	Completed	-	United States, New Jersey ... 展开 >> Hoffmann - La Roche Inc Nutley, New Jersey, United States, 071101199 收起 <<
NCT00002177	HIV Infections	Not Applicable	Completed	-	United States, California ... 展开 >> Univ of California at San Francisco Gen Hosp San Francisco, California, United States, 94110 收起 <<
NCT00385450	Cardiopulmonary Bypass	Phase 1	Terminated(Study closed at May... 展开 >>o prior to completion) 收起 <<	-	United States, Minnesota ... 展开 >> Mayo Clinic Rochester, Minnesota, United States, 55905 收起 <<
NCT00002430	HIV Infections	Not Applicable	Completed	-	-
NCT00006326	HIV Infections	Not Applicable	Terminated	-	United States, California ... 展开 >> Susan Conner San Diego, California, United States, 92121 收起 <<
NCT00009061	HIV Infections	Phase 3	Unknown	-	-
NCT00001094	HIV Infections	Phase 2	Withdrawn	-	United States, California ... 展开 >> Willow Clinic Menlo Park, California, United States, 94025 Stanford Univ Med Ctr Stanford, California, United States, 943055107 United States, Colorado Univ of Colorado Health Sciences Ctr Denver, Colorado, United States, 80262 United States, Florida Univ of Miami School of Medicine Miami, Florida, United States, 331361013 United States, Georgia Emory Univ Atlanta, Georgia, United States, 30308 United States, Hawaii Queens Med Ctr Honolulu, Hawaii, United States, 96816 Univ of Hawaii Honolulu, Hawaii, United States, 96816 United States, Illinois Louis A Weiss Memorial Hosp Chicago, Illinois, United States, 60640 United States, Louisiana Tulane Univ School of Medicine New Orleans, Louisiana, United States, 70112 United States, New York SUNY / Erie County Med Ctr at Buffalo Buffalo, New York, United States, 14215 Bellevue Hosp / New York Univ Med Ctr New York, New York, United States, 10016 United States, North Carolina Carolinas Med Ctr Charlotte, North Carolina, United States, 28203 Moses H Cone Memorial Hosp Greensboro, North Carolina, United States, 27401 United States, Ohio Univ of Cincinnati Cincinnati, Ohio, United States, 452670405 Ohio State Univ Hosp Clinic Columbus, Ohio, United States, 432101228 United States, Texas Univ of Texas Galveston Galveston, Texas, United States, 775550435 Puerto Rico Univ of Puerto Rico San Juan, Puerto Rico, 009365067 收起 <<
NCT00000903	HIV Infections	Phase 3	Completed	-	-
NCT00005000	HIV Infections	Phase 4	Unknown	-	United States, California ... 展开 >> Agouron Pharmaceuticals Inc San Diego, California, United States, 92121 收起 <<
NCT00008554	HIV Infections	Phase 3	Unknown	-	United States, California ... 展开 >> East Bay Clinical Trial Ctr Concord, California, United States, 94520 Ocean View Internal Medicine Long Beach, California, United States, 90803 United States, Florida Florida ID Group Orlando, Florida, United States, 32801 Hillsborough County Health Dept Tampa, Florida, United States, 33602 Clinical Pharmacology Services Tampa, Florida, United States, 33617 United States, Illinois Veterans Affairs Med Ctr of North Chicago Chicago, Illinois, United States, 60064 United States, Kansas Univ of Kansas Med Ctr Kansas City, Kansas, United States, 661607415 United States, New Jersey Saint Michael's Med Ctr Newark, New Jersey, United States, 07102 UMDNJ - New Jersey Med School Newark, New Jersey, United States, 071032757 United States, New York Bronx Municipal Hosp Ctr/Jacobi Med Ctr Bronx, New York, United States, 10461 Addiction Research and Treatment Corp Brooklyn, New York, United States, 11201 Brookdale Univ Hosp and Med Ctr Brooklyn, New York, United States, 112123198 Gervais Frechette New York, New York, United States, 10011 Howard Grossman New York, New York, United States, 10011 Mount Sinai School of Medicine New York, New York, United States, 10029 Univ of Rochester Med Ctr Rochester, New York, United States, 14642 United States, North Carolina SMO-USA Inc Charlotte, North Carolina, United States, 28211 United States, Oregon Advanced Clinical Trials Inc Eugene, Oregon, United States, 97401 United States, Pennsylvania Thomas Jefferson Univ Philadelphia, Pennsylvania, United States, 19107 United States, Texas Univ of Texas Med Branch Galveston, Texas, United States, 775550835 MacGregor Med Association Houston, Texas, United States, 77054 Walter Gaman Irving, Texas, United States, 75038 Southwest Texas Methodist Hosp San Antonio, Texas, United States, 78229 收起 <<
NCT00004985	HIV Infections	Phase 2	Completed	-	-
NCT00000859	HIV Infections	Not Applicable	Completed	-	-
NCT00541463	HIV Infections	Phase 2	Completed	-	-
NCT00002219	HIV Infections	Phase 2	Unknown	-	United States, Florida ... 展开 >> All Children's Hosp St. Petersburg, Florida, United States, 33731 United States, Louisiana Tulane Univ Med Ctr / Dept of Pediatrics New Orleans, Louisiana, United States, 70112 United States, New York Bronx Lebanon Hosp Ctr / Dept of Pediatrics Bronx, New York, United States, 10457 North Shore Univ Hosp / Division of Immunology Great Neck, New York, United States, 11021 St Lukes Roosevelt Hosp Ctr New York, New York, United States, 10025 United States, North Carolina Duke Univ Med Ctr / Duke South Hosp Durham, North Carolina, United States, 27710 United States, South Carolina Med Univ of South Carolina Charleston, South Carolina, United States, 29425 收起 <<
NCT02024009	Pancreatic Neoplasms (Locally ... 展开 >>Advanced Non-metastatic) 收起 <<	Phase 1 Phase 2	Recruiting	August 2020	United Kingdom ... 展开 >> Oxford University Hospitals, Churchill Cancer Centre Recruiting Headington, Oxfordshire, United Kingdom, OX3 7LE Principal Investigator: Dr Somnath Mukherjee Bristol Haematoloy and Oncology Centre Recruiting Bristol, United Kingdom, BS2 8ED Principal Investigator: Dr Stephen Falk Addenbrookes Hospital Recruiting Cambridge, United Kingdom, CB2 0QQ Principal Investigator: Dr Thankamma Ajithkumar Velindre Cancer Centre Recruiting Cardiff, United Kingdom, CF14 2TL Principal Investigator: Dr Seema Arif, Dr Castle Hill Hospital Recruiting Cottingham, United Kingdom, HU16 5JQ Principal Investigator: Dr Rajarshi Roy University Hospital Recruiting Coventry, United Kingdom, CV2 2DX Principal Investigator: Dr Martin Scott-Brown Royal Surrey County Hospital Recruiting Guildford, United Kingdom, GU2 7XX Principal Investigator: Dr Sebastian Cummins St James' Hospital Recruiting Leeds, United Kingdom Principal Investigator: Dr Ganesh Radhakrishna University College London Hospital Not yet recruiting London, United Kingdom, NW1 2BU Principal Investigator: Dr John Bridgewater Royal Free Hospital Recruiting London, United Kingdom, NW3 2PF Principal Investigator: Dr Roopinder Gillmore Hammersmith Hospital Not yet recruiting London, United Kingdom, W12 0HS Principal Investigator: Dr Harpreet Wasan 收起 <<
NCT00002381	HIV Infections	Phase 1	Completed	-	United States, California ... 展开 >> Saint Francis Mem Hosp / HIV Care Unit San Francisco, California, United States, 94109 United States, Rhode Island Roger Williams Med Ctr Providence, Rhode Island, United States, 02908 收起 <<
NCT00146380	HIV Infections	Phase 2	Unknown	January 2013	Kenya ... 展开 >> CDC Clincical Research Center Kisumu, Kenya 收起 <<
NCT00002215	HIV Infections	Not Applicable	Completed	-	United States, Pennsylvania ... 展开 >> Anderson Clinical Research Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT00002235	HIV Infections	Phase 2	Completed	-	United States, California ... 展开 >> Pacific Oaks Med Group Beverly Hills, California, United States, 90211 United States, Colorado Univ of Colorado / Health Science Ctr Denver, Colorado, United States, 80262 United States, Georgia AIDS Research Consortium of Atlanta Atlanta, Georgia, United States, 30308 United States, Rhode Island Brown Univ School of Medicine Providence, Rhode Island, United States, 02908 United States, Virginia Hampton Roads Med Specialists Hampton, Virginia, United States, 23666 收起 <<
NCT00000898	HIV Infections	Not Applicable	Completed	-	United States, California ... 展开 >> San Francisco Gen Hosp San Francisco, California, United States, 941102859 Univ of California/ San Francisco / Dept of Medicine San Francisco, California, United States, 94110 Stanford Univ Med Ctr Stanford, California, United States, 943055107 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 21287 收起 <<
NCT00028067	HIV Infections	Phase 3	Terminated	-	-
NCT00589056	Lung Cancer	Phase 1 Phase 2	Unknown	-	United States, Pennsylvania ... 展开 >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 收起 <<
NCT00000893	HIV Infections	Phase 1	Completed	-	-
NCT02363829	Uterine Cervix Cancer	Phase 1	Recruiting	February 2020	United States, Pennsylvania ... 展开 >> Abramson Cancer Center of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Principal Investigator: Fiona Simpkins, MD 收起 <<
NCT01020292	Glioma	Phase 1	Active, not recruiting	-	United States, Pennsylvania ... 展开 >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00002375	HIV Infections	Not Applicable	Completed	-	United States, Alabama ... 展开 >> Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California UCSD Treatment Ctr / Dept of Medicine and Pediatrics San Diego, California, United States, 92103 United States, Pennsylvania Univ of Pittsburgh / Graduate School of Public Health Pittsburgh, Pennsylvania, United States, 15261 收起 <<
NCT00004999	HIV Infections	Phase 2	Suspended	-	-
NCT02207439	Stage III, IVa, or IVb Squamou... 展开 >>s Cell Carcinoma of the Oral Cavity, Oropharynx, Larynx, or Hypopharynx 收起 <<	Phase 2	Recruiting	-	United States, Pennsylvania ... 展开 >> Abramson Cancer Center of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Dana Patsch 215-615-5645 Dana.Patsch@uphs.upenn.edu Principal Investigator: Alexander Lin, MD 收起 <<
NCT00346619	Immune Response	Phase 1	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic Rochester, Minnesota, United States, 55905 收起 <<
NCT00002201	HIV Infections	Not Applicable	Completed	-	United States, Maryland ... 展开 >> Johns Hopkins Hosp Baltimore, Maryland, United States, 21287 收起 <<
NCT00006211	HIV Infections	Phase 2	Completed	-	United States, California ... 展开 >> Lisa Bauman San Diego, California, United States, 92121 收起 <<
NCT00000887	HIV Infections ... 展开 >> Pregnancy 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> Usc La Nichd Crs Los Angeles, California, United States, 90033 United States, Louisiana Tulane Univ. Health Science Ctr., Tulane Univ. Hosp. & Clinic New Orleans, Louisiana, United States, 701122699 Tulane/LSU Maternal/Child CRS New Orleans, Louisiana, United States, 70112 United States, Maryland Johns Hopkins Hosp. & Health System - Dept. of Peds., Div. of Infectious Diseases Baltimore, Maryland, United States, 212874933 United States, Massachusetts HMS - Children's Hosp. Boston, Div. of Infectious Diseases Boston, Massachusetts, United States, 021155724 United States, North Carolina UNC at Chapel Hill School of Medicine - Dept. of Peds., Div. of Immunology & Infectious Diseases Chapel Hill, North Carolina, United States, 27710 United States, Pennsylvania St. Christopher's Hosp. for Children Philadelphia, Pennsylvania, United States, 191341095 收起 <<
NCT00650637	Diarrhea	Phase 3	Terminated(The study was prema... 展开 >>turely discontinued due to administrative reasons on August 18, 2003. There were no safety concerns that led to the decision to terminate.) 收起 <<	-	United States, Alabama ... 展开 >> Pfizer Investigational Site Birmingham, Alabama, United States, 35233 United States, Florida Pfizer Investigational Site Ft. Lauderdale, Florida, United States, 33308 United States, New York Pfizer Investigational Site New York, New York, United States, 10011 United States, North Carolina Pfizer Investigational Site Huntersville, North Carolina, United States, 28078 United States, Texas Pfizer Investigational Site Austin, Texas, United States, 78705 Pfizer Investigational Site Houston, Texas, United States, 77098 收起 <<
NCT00312182	Healthy Volunteers	Phase 4	Completed	-	United States, Connecticut ... 展开 >> Pfizer Investigational Site New Haven, Connecticut, United States, 06511-5473 United States, Michigan Pfizer Investigational Site Ann Arbor, Michigan, United States, 48105 Belgium Pfizer Investigational Site Bruxelles, Belgium, B-1070 Singapore Pfizer Investigational Site Singapore, Singapore, 169608 收起 <<
NCT00023400	HIV Infections ... 展开 >> Tuberculosis 收起 <<	Phase 4	Completed	-	-
NCT00141284	HIV Infection ... 展开 >> Hepatitis C 收起 <<	Phase 4	Completed	-	United States, California ... 展开 >> Pfizer Investigational Site Bakersfield, California, United States, 93301 United States, Florida Pfizer Investigational Site Miami, Florida, United States, 33136 United States, Louisiana Pfizer Investigational Site Shreveport, Louisiana, United States, 71130 United States, Texas Pfizer Investigational Site Dallas, Texas, United States, 75390 Canada, Ontario Pfizer Investigational Site Toronto, Ontario, Canada, M5G 2C4 收起 <<
NCT00002170	Mycobacterium Avium-Intracellu... 展开 >>lare Infection HIV Infections 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> Univ of California / San Diego Treatment Ctr San Diego, California, United States, 92103 Harbor UCLA Med Ctr Torrance, California, United States, 90502 United States, Illinois Rush Presbyterian - Saint Luke's Med Ctr Chicago, Illinois, United States, 60612 United States, Massachusetts Boston VA Med Ctr / 151 Boston, Massachusetts, United States, 02730 United States, Texas Baylor Univ Houston, Texas, United States, 77009 收起 <<
NCT00002169	Cytomegalovirus Retinitis ... 展开 >> HIV Infections 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> Univ of Southern California / LA County USC Med Cntr Los Angeles, California, United States, 90033 Univ of California / UCI Med Ctr Orange, California, United States, 92868 Univ of California / San Diego Treatment Ctr San Diego, California, United States, 92103 Harbor UCLA Med Ctr Torrance, California, United States, 90502 United States, District of Columbia George Washington Univ Washington, District of Columbia, United States, 20037 United States, Illinois Northwestern Univ / SOCA Chicago, Illinois, United States, 60611 United States, Texas Univ of Texas Med Branch Galveston, Texas, United States, 77555 Baylor Univ Houston, Texas, United States, 77009 收起 <<
NCT01108666	Non Small Cell Lung Cancer	Phase 1	Unknown	-	United States, Pennsylvania ... 展开 >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT01959672	Pancreatic Adenocarcinoma ... 展开 >> Resectable Pancreatic Carcinoma Stage I Pancreatic Cancer Stage IA Pancreatic Cancer Stage IB Pancreatic Cancer Stage II Pancreatic Cancer Stage IIA Pancreatic Cancer Stage IIB Pancreatic Cancer Stage III Pancreatic Cancer 收起 <<	Phase 2	Active, not recruiting	December 2019	United States, Nebraska ... 展开 >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 收起 <<
NCT00002171	HIV Infections	Phase 2	Completed	-	United States, Alabama ... 展开 >> Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California Univ of Southern California / LA County USC Med Cntr Los Angeles, California, United States, 90033 United States, Louisiana HIV Outpatient Clinics / LA State Univ Med Ctr New Orleans, Louisiana, United States, 70112 United States, Texas Baylor Univ Houston, Texas, United States, 77009 收起 <<
NCT00002164	HIV Infections	Phase 1	Completed	-	United States, California ... 展开 >> UCLA School of Medicine / Dept of Pediatrics Los Angeles, California, United States, 90024 收起 <<
NCT00002185	Sarcoma, Kaposi ... 展开 >> HIV Infections 收起 <<	Phase 2	Completed	-	United States, California ... 展开 >> LAC and USC Med Ctr / School of Medicine Los Angeles, California, United States, 90033 Univ of California / UCI Med Ctr Orange, California, United States, 92868 UCSD Treatment Ctr San Diego, California, United States, 92103 Santa Clara Valley Med Ctr San Jose, California, United States, 951282699 Harbor - UCLA Med Ctr - Box 449 Torrance, California, United States, 90509 收起 <<
NCT00205283	HIV Infections	Not Applicable	Unknown	-	United States, Wisconsin ... 展开 >> University of Wisconsin Hospital and Clinics Recruiting Madison, Wisconsin, United States, 53792 Contact: Andrew Urban, MD 608-256-1901 ext 17472 andrew.urban@med.va.gov 收起 <<
NCT00233948	Adult Liposarcoma ... 展开 >> Recurrent Adult Soft Tissue Sarcoma Stage III Adult Soft Tissue Sarcoma Stage IV Adult Soft Tissue Sarcoma 收起 <<	Phase 1 Phase 2	Terminated(Drug availability i... 展开 >>ssues) 收起 <<	-	United States, California ... 展开 >> City of Hope Medical Center Duarte, California, United States, 91010 South Pasadena Cancer Center Pasadena, California, United States, 91030 收起 <<
NCT00002165	HIV Infections	Not Applicable	Completed	-	United States, California ... 展开 >> Agouron Pharmaceuticals Inc San Diego, California, United States, 92121 收起 <<
NCT00233948	-		Terminated(Drug availability i... 展开 >>ssues) 收起 <<	-	-
NCT01068327	Adenocarcinoma of the Pancreas... 展开 >> Stage III Pancreatic Cancer 收起 <<	Phase 1	Active, not recruiting	April 2019	United States, Nebraska ... 展开 >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 收起 <<
NCT03050060	Metastatic Renal Cell Cancer ... 展开 >> Recurrent Melanoma Recurrent Non-Small Cell Lung Carcinoma Recurrent Renal Cell Carcinoma Stage IV Cutaneous Melanoma AJCC v6 and v7 Stage IV Non-Small Cell Lung Cancer AJCC v7 Stage IV Renal Cell Cancer AJCC v7 收起 <<	Phase 2	Recruiting	December 1, 2021	United States, Washington ... 展开 >> Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Ramesh Rengan 206-598-4100 rengan@uw.edu Principal Investigator: Ramesh Rengan 收起 <<
NCT00694837	Glioblastoma	Phase 1	Completed	-	Netherlands ... 展开 >> Maastricht Radiation Oncology Maastricht, Netherlands, 6202 AZ 收起 <<
NCT00251030	Healthy Volunteers	Phase 4	Completed	-	United States, Michigan ... 展开 >> Pfizer Investigational Site Kalamazoo, Michigan, United States, 49007 收起 <<
NCT01445106	Solid Tumors	Phase 1	Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT01086332	Pancreatic Neoplasms	Phase 1	Terminated(Toxicities, lack of... 展开 >> funding) 收起 <<	-	-
NCT01485731	Cervical Cancer	Phase 1	Completed	-	United States, Florida ... 展开 >> University of Miami Miami, Florida, United States, 33136 收起 <<
NCT00791336	-		Terminated(Poor enrollment.)	-	-
NCT03256916	Carcinoma Cervix, Stage III	Phase 3	Not yet recruiting	September 30, 2025	India ... 展开 >> Tata Memorial Centre Not yet recruiting Mumbai, Maharashtra, India, 400012 Contact: Supriya J Sastri, MD 9930958309 supriyasastri@gmail.com Contact: Jayant Goda, MD 24177000 ext 7027 godajayantsastri@gmail.com Principal Investigator: Supriya J Sastri, MD Principal Investigator: Jayant Goda, MD 收起 <<
NCT00791336	Carcinoma, Non-Small-Cell Lung	Phase 2	Terminated(Poor enrollment.)	-	United States, Iowa ... 展开 >> The University of Iowa Department of Radiation Oncology Iowa City, Iowa, United States, 52242 收起 <<
NCT01555281	Multiple Myeloma	Phase 1 Phase 2	Active, not recruiting	December 2019	Italy ... 展开 >> Istituto Europeo di Oncologia IEO Milano, Italy, 20141 University of Torino Torino, Italy, 10127 Switzerland Kantonsspital Aarau Aarau, Switzerland, 5001 Kantonsspital Baden Baden, Switzerland, 5404 Istituto Oncologico Svizzera Italiana IOSI Bellinzona, Switzerland, 6500 Inselspital Bern Bern, Switzerland, 3010 Kantonsspital Graubünden Chur, Switzerland, 7000 Kantonsspital Olten Olten, Switzerland, 4600 Kantonsspital St. Gallen St. Gallen, Switzerland, 9007 Regionalspital Thun, Switzerland, 3600 UniversitätsSpital Zürich Zürich, Switzerland, 8091 收起 <<
NCT01065844	Carcinoma, Adenoid Cystic ... 展开 >> Head and Neck Neoplasms 收起 <<	Phase 2	Completed	-	United States, Iowa ... 展开 >> The Holden Comprehensive Cancer Center Iowa City, Iowa, United States, 52242 收起 <<
NCT01079286	Renal Cell Cancer ... 展开 >> Cancer 收起 <<	Phase 1	Completed	-	Netherlands ... 展开 >> Academic Medical Center Amsterdam, Netherlands, 1105AZ 收起 <<
NCT01065844	-		Completed	-	-
NCT01164709	Leukemia Lymp... 展开 >>homa Mature T-cell and Nk-cell Neoplasms Multiple Myeloma and Plasma Cell Neoplasm 收起 <<	Phase 1	Completed	-	Switzerland ... 展开 >> Inselspital Bern Bern, Switzerland, CH-3010 Kantonsspital Graubuenden Chur, Switzerland, CH-7000 Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland, CH-1011 Kantonsspital - St. Gallen St. Gallen, Switzerland, CH-9007 收起 <<
NCT02188537	Myeloma	Phase 2	Completed	-	Switzerland ... 展开 >> Kantonsspital Aarau Aarau, Switzerland, CH-5001 Kantonsspital Baden Baden, Switzerland, 5404 Universitaetsspital-Basel Basel, Switzerland, CH-4031 Istituto Oncologico Svizzera Italiana IOSI Bellinzona, Switzerland, 6500 Inselspital Bern Bern, Switzerland, 3010 Kantonsspital Graubuenden Chur, Switzerland, CH-7000 Hopital Fribourgeois Fribourg, Switzerland, 1708 Hopital Cantonal Universitaire de Geneve Geneva, Switzerland, CH-1211 Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland, CH-1011 Kantonsspital - St. Gallen St. Gallen, Switzerland, CH-9007 SpitalSTS AG Simmental-Thun-Saanenland Thun, Switzerland, 3600 UniversitätsSpital Zürich Zürich, Switzerland, 8091 收起 <<
NCT01728779	Oligometastases	Phase 2	Active, not recruiting	July 2021	United States, Maryland ... 展开 >> The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 收起 <<
NCT00915694	Brain and Central Nervous Syst... 展开 >>em Tumors 收起 <<	Phase 1	Unknown	-	United States, Pennsylvania ... 展开 >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 收起 <<
NCT01925378	Cervical Dysplasia	Phase 2	Recruiting	December 2022	United States, Texas ... 展开 >> The University of Texas Health Science Center at Houston Recruiting Houston, Texas, United States, 77030 Contact: Joseph A. Lucci, MD 713-500-5691 Joseph.A.Lucci@uth.tmc.edu Contact: Sonia C Robazetti, MD,CCRC 7135006382 sonia.r.hodgson@uth.tmc.edu 收起 <<
NCT02066311	Systemic Lupus Erythematosus	Phase 2	Completed	-	United States, California ... 展开 >> Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 UCLA David Geffen School of Medicine Los Angeles, California, United States, 90095 United States, Illinois Rush University Medical Center Chicago, Illinois, United States, 60612 United States, New York Bronx Lebanon Hospital Bronx, New York, United States, 10457 The Feinstein Institute for Medical Research Manhasset, New York, United States, 11030 New York University School of Medicine New York, New York, United States, 10016 Columbia University Medical Center New York, New York, United States, 10032 Hospital for Special Surgery New York, New York, United States, 20021 收起 <<
NCT01447589	Lung Cancer	Phase 1 Phase 2	Withdrawn(failed to recruit, n... 展开 >>o suitable patients) 收起 <<	-	United Kingdom ... 展开 >> Oxford Radcliffe NHS Trust Oxford, Oxfordshire, United Kingdom, OX3 9DU 收起 <<
NCT02080416	Non-Hodgkin Lymphoma ... 展开 >> Hodgkin Lymphoma Kaposi Sarcoma Gastric Cancer Nasopharyngeal Cancer EBV Castleman Disease 收起 <<	Early Phase 1	Terminated(Very slow accrual; ... 展开 >>terminated to allow resources to be utilized more effectively on other studies. No data analysis completed, nor any conclusions reached.) 收起 <<	-	United States, Maryland ... 展开 >> The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21287 收起 <<
NCT03422874	Neoplasms Lym... 展开 >>phoma 收起 <<	Phase 1	Withdrawn(Sponsor withdrew sup... 展开 >>port) 收起 <<	August 4, 2017	United States, New Hampshire ... 展开 >> Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756 收起 <<
NCT00704600	Colorectal Cancer ... 展开 >> Colorectal Carcinoma Colorectal Tumors Neoplasms, Colorectal 收起 <<	Phase 1 Phase 2	Completed	-	Netherlands ... 展开 >> Maastro clinic Maastricht, Netherlands, 6229 ET 收起 <<
NCT00246610	HIV Infection	Phase 4	Completed	-	United States, Florida ... 展开 >> Pfizer Investigational Site Jacksonville, Florida, United States, 32209 Pfizer Investigational Site Miami, Florida, United States, 33136 United States, Louisiana Pfizer Investigational Site Metairie, Louisiana, United States, 70006 United States, Michigan Pfizer Investigational Site Detroit, Michigan, United States, 48201 United States, Pennsylvania Pfizer Investigational Site Philadelphia, Pennsylvania, United States, 19410 Canada, Ontario Pfizer Investigational Site Toronto, Ontario, Canada, M5G 2N2 收起 <<
NCT03077451	Recurrent Kaposi Sarcoma ... 展开 >> Skin Kaposi Sarcoma 收起 <<	Phase 2	Recruiting	November 2019	United States, California ... 展开 >> UCLA Clinical AIDS Research and Education (CARE) Center Recruiting Los Angeles, California, United States, 90095-1793 Contact: Maricela Gonzalez 310-557-3729 mmgonzalez@mednet.ecla.edu Principal Investigator: Ronald Mitsuyasu, MD United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting Baltimore, Maryland, United States, 21231-2410 Contact: Clinical Trials Office - Sidney Kimmel Comprehensive Cancer Ce 410-955-8804 jhcccro@jhmi.edu Principal Investigator: Richard Ambinder, MD United States, Massachusetts Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: Erin Sullivan, NP 617-667-3087 Esulliv1@bidmc.harvard.edu Principal Investigator: Ayad Hamdan, MD United States, Missouri Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Lee Ratner, MD 800-600-3606 info@sitman.wustl.edu Principal Investigator: Lee Ratner, MD United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Mark Dickson, MD 646-888-4164 dicksonm@mskcc.org Principal Investigator: Mark Dickson, MD United States, Ohio Ohio State University Recruiting Columbus, Ohio, United States, 43210 Contact: Lisa Brenner 614-293-7843 Lisa.Brenner@osumc.edu Principal Investigator: Robert Baiocchi, MD United States, Pennsylvania Fox Chase Cancer Center Recruiting Philadelphia, Pennsylvania, United States, 19111 Contact: Stefan Barta, MD 215-728-2674 Stefan.barta@fccc.edu Principal Investigator: Stefan Barta, MD United States, Washington Benaroya Research Institute at Virginia Mason Medical Center Recruiting Seattle, Washington, United States, 98101 Contact: Clinical Trials Office - Benaroya Research Institute 206-583-6526 hemdma@vmmc.org Contact: David Aboulafia, MD hemdma@vmmc.org Principal Investigator: David Aboulafia, MD Harborview Medical Center Recruiting Seattle, Washington, United States, 98104 Contact: Alison Kunze 206-744-5828 kunzea@uw.edu Principal Investigator: Manoj Menon, MD Uganda Uganda Cancer Institute Not yet recruiting Kampala, Uganda Contact: Jackson Orem, MD Principal Investigator: Jackson Orem, MD 收起 <<

靶点	HIV Protease HIV protease, Ki:2 nM
描述	Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Additionally, Nelfinavir Mesylate (AG 1343 Mesylate) exhibits broad-spectrum anticancer activity ^[1]^[2]^[3].
体内研究	In NOD/SCID mice, administration of Nelfinavir Mesylate (75 mg/kg; i.p.; 5 days a week for 21 days) suppresses the growth of multiple myeloma cells ^[4].
体外研究	Nelfinavir (AG1341) Mesylate (1-10 μM; 48 hours) suppresses the proliferation of multiple myeloma cells ^[4]. The inhibition of 26S chymotrypsin-like proteasome activity by Nelfinavir Mesylate impedes proliferation and induces apoptosis in myeloma cell lines and fresh plasma cells ^[4]. Exposure to Nelfinavir Mesylate (1-10 μM; 17 hours) triggers apoptosis in multiple myeloma cell lines ^[4]. Treatment with Nelfinavir Mesylate (5 μM; 0-24 hours) reduces AKT phosphorylation ^[4]. Nelfinavir Mesylate promotes caspase-3 cleavage, attenuates AKT, STAT-3, ERK1/2 phosphorylation, and activates the pro-apoptotic pathway of the unfolded protein response system ^[4]. Moreover, Nelfinavir serves as an inhibitor of SARS-CoV 3CLpro with an IC50 of 35.93 μM ^[5].

CAS号	159989-65-8
分子式	C₃₃H₄₉N₃O₇S₂
分子量	663.888

别名	AG 1343 Mesylate;Nelfinavir (mesylate);Nelfin;AG-1343
运输	蓝冰

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