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达芦那韦 /Darunavir {[allProObj[0].p_purity_real_show]}

货号：A116353 同义名： 地瑞那韦 / UIC-94017;TMC114

Darunavir is a protease inhibitor which acts on the HIV aspartyl protease.

Darunavir 化学结构 CAS号：206361-99-1
Darunavir 化学结构
CAS号：206361-99-1
Darunavir 3D分子结构
CAS号：206361-99-1
Darunavir 化学结构 CAS号：206361-99-1
Darunavir 3D分子结构 CAS号：206361-99-1
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Darunavir 纯度/质量文件 产品仅供科研

货号：A116353 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 HIV Protease ↓ HIV-1 caspid ↓ 其他靶点 纯度
Dextran sulfate sodium, mw 40,000 ✔ M.W 40000
Vicriviroc maleate ✔ 98+%
Rosamultin ✔ 97%
Darunavir ✔ 98%
Lopinavir ++++

HIV protease, Ki: 1.3 pM

 		99+%
Chloroquine ✔ Autophagy 95%
Amprenavir +

HIV protease, IC50: 14.6 ng/mL

 		PXR 99%+
NBD-556 ✔ 99%+
Nelfinavir Mesylate +++

HIV protease, Ki: 2 nM

 		99%+
Atazanavir Sulfate ✔ 98%
Limonin ✔ 98%
Saquinavir ++

HIV proteinase, IC50: 2.7 nM

 		98%
Ritonavir ✔ 98%
Azvudine ✔ 98%
Lenacapavir ++++

HIV-1 capsid, EC50: 0.1 nM

 		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Darunavir 生物活性

靶点

  • HIV Protease
描述 Darunavir is an antiretroviral protease inhibitor that is used in the therapy and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS). Darunavir is a proteinomimetic, azapeptide that blocks the catalytic site of the HIV protease preventing cleavage of viral polyprotein precursors into mature, functional proteins that are necessary for viral replication. Ritonavir-boosted darunavir, as a component of antiretroviral therapy (ART), is indicated for the treatment of HIV-1 infection in adult and paediatric patients Boosted darunavir is generally well tolerated, with gastrointestinal disturbances and lipid abnormalities among the most common tolerability issues[3]. Darunavir is a nonpeptidic inhibitor of protease (PR) that lodges itself in the active site of PR through a number of hydrogen bonds. Darunavir interacts with these catalytic aspartates and the backbone of the active site through hydrogen bonds, specifically binding to residues Asp25, Asp25’, Asp 29, Asp 30, Asp 30’, and Gly 27. This interaction prevents viral replication, as it competitively inhibits the viral polypeptides from gaining access to the active site and strongly binds to the enzymatic portions of this protein [4].

Darunavir 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03042390 - Completed - Spain ... 展开 >> Hospital Costa del Sol Malaga, Marbella, Spain Hospital Clinic i Provincial Barcelona, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain Hospital del Mar Barcelona, Spain Hospital del Vall d'Hebron Barcelona, Spain Hospital Germans Trias i Pujol Barcelona, Spain Hospital de Guadalajara Guadalajara, Spain Hospital Infanta Leonor Madrid, Spain Hospital La Paz Madrid, Spain Hospital La Princesa Madrid, Spain Hospital Príncipe de Asturias Madrid, Spain Hospital Puerta de Hierro Madrid, Spain Hospital Ramón y Cajal Madrid, Spain Hospital Virgen de la Victoria Malaga, Spain Hospital de Son Llatzer Palma de Mallorca, Spain Hospital de Valme Sevilla, Spain Complejo Hospitalario de Toledo Toledo, Spain Hospital Clínico de Valencia Valencia, Spain Hospital La Fe Valencia, Spain Complejo Hospitalaria Alvaron Cunqueiro Vigo, Spain 收起 <<
NCT01449929 Infection, Human Immunodeficie... 展开 >>ncy Virus 收起 << Phase 3 Completed - -
NCT00854204 HIV-I Phase 1 Completed - -

Darunavir 参考文献

[1]Meher BR, Wang Y. Interaction of I50V mutant and I50L/A71V double mutant HIV-protease with inhibitor TMC114 (darunavir): molecular dynamics simulation and binding free energy studies. J Phys Chem B. 2012 Feb 16;116(6):1884-900.

[2]Kovalevsky AY, Louis JM, et al. Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease. J Mol Biol. 2008 Dec 5;384(1):178-92.

[3]Deeks ED. Darunavir: a review of its use in the management of HIV-1 infection. Drugs. 2014 Jan;74(1):99-125. doi: 10.1007/s40265-013-0159-3. PMID: 24338166.

[4] Leonis G, Czyżnikowska Ż, Megariotis G, Reis H, Papadopoulos MG. Computational studies of darunavir into HIV-1 protease and DMPC bilayer: necessary conditions for effective binding and the role of the flaps. J Chem Inf Model. 2012 Jun 25;52(6):1542-58. doi: 10.1021/ci300014z. Epub 2012 May 30. PMID: 22587384.

Darunavir 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.13mL

1.83mL

0.91mL

18.26mL

3.65mL

1.83mL

Darunavir 技术信息

CAS号206361-99-1
分子式C27H37N3O7S
分子量 547.664
别名 地瑞那韦 ;UIC-94017;TMC114
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 105 mg/mL(191.72 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Darunavir | 206361-99-1 | TMC114 | UIC-94017 | TMC 114 | TMC-114 | UIC94017 | UIC 94017 | UIC-94017 | HIV Protease Inhibitor | Anti-infection | Metabolic Enzyme/Protease | HIV | HIV Protease | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Darunavir 纯度/质量文件 | Darunavir 亚型比较 | Darunavir 生物活性 | Darunavir 临床数据 | Darunavir 参考文献 | Darunavir 实验方案 | Darunavir 技术信息

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