Saquinavir is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir could inhibit SARS-CoV-2 3CLpro main protease.
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产品名称 | HIV Protease ↓ ↑ | HIV-1 caspid ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dextran sulfate sodium, mw 40,000 | ✔ | M.W 40000 | |||||||||||||||||
Vicriviroc maleate | ✔ | 98+% | |||||||||||||||||
Rosamultin | ✔ | 97% | |||||||||||||||||
Darunavir | ✔ | 98% | |||||||||||||||||
Lopinavir |
++++
HIV protease, Ki: 1.3 pM |
99+% | |||||||||||||||||
Chloroquine | ✔ | Autophagy | 95% | ||||||||||||||||
Amprenavir |
+
HIV protease, IC50: 14.6 ng/mL |
PXR | 99%+ | ||||||||||||||||
NBD-556 | ✔ | 99%+ | |||||||||||||||||
Nelfinavir Mesylate |
+++
HIV protease, Ki: 2 nM |
99%+ | |||||||||||||||||
Atazanavir Sulfate | ✔ | 98% | |||||||||||||||||
Limonin | ✔ | 98% | |||||||||||||||||
Saquinavir |
++
HIV proteinase, IC50: 2.7 nM |
98% | |||||||||||||||||
Ritonavir | ✔ | 98% | |||||||||||||||||
Azvudine | ✔ | 98% | |||||||||||||||||
Lenacapavir |
++++
HIV-1 capsid, EC50: 0.1 nM |
97% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Saquinavir is an orally active and selective HIV proteinase inhibitor. It was highly active against HIV in human cells that are acutely or chronically infected with the virus in in vitro study. Saquinavir had IC50 and IC90 values ranged from 1-30nM and 5-80nM, respectively. Recent study found that Saquinavir showed inhibition effect on 2019-nCoV. |
作用机制 | Saquinavir is a peptide-like substrate analogue that inhibits HIV protease, which is required for the cleavage of viral polyprotein precursor into individual functional proteins as found in infectious HIV, by binding to its active site. Inhibition of HIV protease leads to the production of immature non-infectious virus particles. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT01936870 | - | Completed | - | - | |
NCT01936870 | - | Completed | - | - | |
NCT02556268 | HIV-DDI | Phase 1 | Completed | - | United States, Florida ... 展开 >> Orlando, Florida, United States, 32803 United States, Massachusetts Boston, Massachusetts, United States, 02118 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.49mL 0.30mL 0.15mL |
7.45mL 1.49mL 0.75mL |
14.91mL 2.98mL 1.49mL |
CAS号 | 127779-20-8 |
分子式 | C38H50N6O5 |
分子量 | 670.841 |
别名 | Ro 31-8959 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Sealed in dry,Store in freezer, under -20°C |
溶解度 |
DMSO: 105 mg/mL(156.52 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |