SB 203580 | RWJ 64809 | p38 MAPK Inhibitor | AmBeed-信号通路专用抑制剂

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SB 203580 {[allProObj[0].p_purity_real_show]}

货号：A248150 同义名： RWJ 64809;Adezmapimod

SB-203580 (Adezmapimod) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM.

SB 203580 化学结构
CAS号：152121-47-6

SB 203580 3D分子结构
CAS号：152121-47-6

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SB 203580 纯度/质量文件产品仅供科研

货号：A248150 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

p38 MAPK 亚型比较
Akt 亚型比较

产品名称	p38 MAPK ↓ ↑	p38α ↓ ↑	p38β ↓ ↑	其他靶点	纯度
BMS-582949	+++ p38 MAPK, IC50: 13 nM				98%
SB 203580					99%+
Pexmetinib	✔			Tie-2	99%+
Skepinone-L		++++ p38α, IC50: 5 nM			98%
Doramapimod		++++ p38α, IC50: 38 nM p38α, Kd: 0.1 nM			99%+
VX-702					99%+
Ralimetinib dimesylate		++++ p38α, IC50: 7 nM			98%
SB 202190		++ p38α, IC50: 50 nM	++ p38β, IC50: 100 nM		99%+
Losmapimod		++++ p38α, pKi: 8.1	+++ p38β, pKi: 7.6		99%+
Neflamapimod		+++ p38α, IC50: 10 nM	+ p38β, IC50: 220 nM		99%+
PH-797804		++ p38α, IC50: 26 nM	+ p38β, IC50: 102 nM		98%
TAK-715		++++ p38α, IC50: 7.1 nM	+ p38β, IC50: 0.20 μM		99%+
SB 239063		++ p38α, IC50: 44 nM	++ p38β, IC50: 44 nM		99%+
Pamapimod		+++ p38α, IC50: 0.014 μM	+ p38β, IC50: 0.48 μM		98%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Akt ↓ ↑	Akt1 ↓ ↑	Akt2 ↓ ↑	Akt3 ↓ ↑	其他靶点	纯度
Honokiol	✔				MEK	98%
PF-04691502	++++ P-Akt (S473), IC50: 3.8 nM P-Akt (T308), IC50: 7.5 nM					98+%
PHT-427	+ Akt, Ki: 2.7 μM					99%+
Deguelin	✔				PI3K	99%+
TIC10 isomer	✔				ERK	98+%
Perifosine	+ Akt, IC50: 4.7 μM					98%
Miltefosine	✔				PI3K,PKC	98%
Triciribine	+ Akt, IC50: 130 nM					99%+
Uprosertib		+ Akt1, IC50: 180 nM	+ Akt2, IC50: 328 nM	++ Akt3, IC50: 38 nM		99%+
Afuresertib		++++ Akt1, Ki: 0.08 nM	++++ Akt2, Ki: 2 nM	++++ Akt3, Ki: 2.6 nM		99%+
Miransertib		++++ Akt1, IC50: 5 nM	++++ Akt2, IC50: 4.5 nM	++ Akt3, IC50: 16 nM		98+%
GSK-690693		++++ Akt1, IC50: 2 nM	+++ Akt2, IC50: 13 nM	+++ Akt3, IC50: 9 nM		99%+
AT7867		++ Akt1, IC50: 32 nM	++ Akt2, IC50: 17 nM	++ Akt3, IC50: 47 nM	PKA	99%+
AKT inhibitor VIII		++ Akt1, IC50: 58 nM	+ Akt2, IC50: 210 nM	+ Akt3, IC50: 2119 nM		98+%
MK-2206 2HCl		+++ Akt1, IC50: 8 nM	+++ Akt2, IC50: 12 nM	+ Akt3, IC50: 65 nM		99%+
Ipatasertib		++++ Akt1, IC50: 5 nM	++ Akt2, IC50: 18 nM	+++ Akt3, IC50: 8 nM		99%+
AT13148		++ Akt1, IC50: 38 nM	+ Akt2, IC50: 402 nM	++ Akt3, IC50: 50 nM	PKA	98+%
Capivasertib		++++ Akt1, IC50: 3 nM	+++ Akt2, IC50: 8 nM	+++ Akt3, IC50: 8 nM		99%+
A-674563 HCl		+++ Akt1, Ki: 11 nM			PKA	98%
CCT128930			+++ Akt2, IC50: 6 nM		PKA	98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

SB 203580 生物活性

靶点

p38 MAPK

p38 MAPK, IC50:0.3 μM-0.5 μM

描述

The stress-activated protein kinase (SAPK) p38 isoforms are mitogen-activated protein kinase (MAPK) family members. MAPKs act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
SB 203580 is a p38 MAPK inhibitor. SB 203580 inhibited the ATPase activity of non-phosphorylated p38 MAPK with a K_m of 9.6 mM. SB 203580 was competitive with ATP with a K_i of 21 nM, detected in a kinetic study of yeast expressed active p38 MAPK^[3]. 24h treatment of SB 203580 dose-dependently inhibited IL-1β-induced PGE₂ release with an EC₅₀ of 0.18 μM^[4].
SB 203580 was dissolved in drinking water at the concentration of 250 μM and orally administrated 0.4 ml/day to MRL/lpr mice aged from 14 to 22 weeks. SB203580 improved renal function by decreasing the levels of proteinuria and serum BUN, ameliorating the pathologic changes of kidney and reducing Ig and C3 depositions in the kidney. Moreover, hepatocytes necrosis, recruitment and proliferation of leucocytes in liver and spleen were found to be inhibited by administration of SB203580^[5].

SB 203580 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
HCA2	2.5 μM	Function Assay		Inhibits p38 mediated MK2 activation	17964780
Hela		Function Assay		Inhibits Tat-induced HIV1 LTR transactivation in human HeLa cells with IC50 of 0.1 μM	18926711
hESCs	5 μM	Growth Inhibition Assay		Induces cardiomyogenic activity assessed as cell growth	23602399
IEC-18	10 μM	Function Assay		Inhibits LPS-induced p38 MAPK phosphorylation	23758110

SB 203580 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.26mL

13.25mL

2.65mL

1.32mL

26.49mL

5.30mL

2.65mL

SB 203580 技术信息

CAS号	152121-47-6
分子式	C₂₁H₁₆FN₃OS
分子量	377.435

别名	RWJ 64809;Adezmapimod;SB203850;PB 203580
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 18 mg/mL(47.69 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 4 mg/mL clear

PO 0.5% CMC-Na 60 mg/mL suspension

HCA2	2.5 μM	Function Assay		Inhibits p38 mediated MK2 activation	17964780
Hela		Function Assay		Inhibits Tat-induced HIV1 LTR transactivation in human HeLa cells with IC50 of 0.1 μM	18926711
hESCs	5 μM	Growth Inhibition Assay		Induces cardiomyogenic activity assessed as cell growth	23602399
IEC-18	10 μM	Function Assay		Inhibits LPS-induced p38 MAPK phosphorylation	23758110
PBMC		Function Assay	15 min	Inhibits the release of interleukin-1-beta with IC50 of 0.037 μM	12361396
PC12	10 μM	Kinase Assay	15 min	Inhibits p38 MAP kinase with IC50 of 0.6 μM	7750577
PC12	10 μM	Function Assay		Activates Nrf2/ARE in rat PC12 cells assessed as HO-1 protein induction	21345685
RAW 264.7	12.5 μM	Cytotoxic Assay	12h	Blocks lethal toxin-mediated cytotoxicity	17485504
RAW264.7	10 μM	Function Assay		Induces antiinflammatory activity by inhibiting IL-1β release	23791078
RAW264.7	10 μM	Function Assay		Induces antiinflammatory activity by inhibiting iNOS release	23791078
RAW264.7	10 μM	Function Assay		Induces antiinflammatory activity by inhibiting NO release	23791078
RAW264.7	10 μM	Function Assay		Inhibits LPS-induced p38 MAPK phosphorylation	24016057
SW1353		Function Assay	1 h	Inhibits IL-6 production with IC50 of 0.05 μM	11140741
THP-1		Function Assay		Inhibits LPS-induced TNFalpha production with IC50 of 0.16 μM	18325768
U937		Function Assay		Inhibits JAK-mediated interferon-gamma/anisomycin-induced Stat1 phosphorylation	18157122
U937		Function Assay		Inhibits JAK-mediated interferon-gamma/anisomycin-induced p38 phosphorylation	18157122

SB 203580 {[allProObj[0].p_purity_real_show]}

SB 203580 纯度/质量文件产品仅供科研

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SB 203580 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

SB 203580 质控信息

SB 203580 生物活性

SB 203580 细胞研究

SB 203580 实验方案

SB 203580 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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