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Necroptosis-IN-3
Necroptosis-IN-3
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货号：A1217669
Necroptosis-IN-3是一种坏死性凋亡 (necroptosis) 抑制剂，通过抑制 TNF-α 诱导的坏死性凋亡通路，展现出抗炎和抗纤维化潜力。
Necroptosis-IN-3 化学结构
CAS号：547698-18-0
Necroptosis-IN-3 3D分子结构
CAS号：547698-18-0
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Necroptosis-IN-3 纯度/质量文件 产品仅供科研
货号：A1217669
标准纯度：
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全球学术期刊中引用的产品
- • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed.
[
A538667 ,
A631746
]
- • JMC, 2024. Ambeed.
[
A833302 ,
A475501 ,
A341986 ,
A356070
]
- • BMC Cancer, 2024, 24(1): 1415. Ambeed.
[
A809692 ,
A209020
]
- • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed.
[
A166127 ,
A902473 ,
A753371 ,
A961334 ,
A292945 ,
A230770 ,
A300620 ,
A1114580 ,
A1159765 ,
A206238
]
- • PloS One, 2024, 19(11): e0308060. Ambeed.
[
A302917
]
- 更多 >
Necroptosis-IN-3 质控信息
| Trilostane |
✔
|
|
99+% |
| AGI-6780 |
+++
IDH2 R140Q mutant, IC50: 23 nM
|
|
99%+ |
| Gimeracil |
✔
|
|
98% |
| AGI-5198 |
++
R132H-IDH1, IC50: 70 nM
R132C-IDH1, IC50: 0.16 μM
|
|
99%+ |
| SW033291 |
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
|
|
99%+ |
| Mycophenolic acid |
✔
|
|
99+% |
| Fomepizole |
✔
|
|
98% |
| Leflunomide |
✔
|
|
98% |
| 3-Nitropropanoic acid |
✔
|
|
99%+ |
| Isovaleramide |
✔
|
|
98% |
| Mycophenolate Mofetil |
+++
Inosine monophosphate dehydrogenase I, IC50: 39 nM
Inosine monophosphate dehydrogenase II, IC50: 27 nM
|
|
98% |
| MK-8245 |
++++
SCD1 (mouse), IC50: 1 nM
SCD1 (rat), IC50: 3 nM
|
|
99%+ |
| Vidofludimus |
++
Human DHODH, IC50: 134 nM
|
|
99%+ |
| Emodin |
✔
|
|
98% |
| Ivosidenib |
✔
|
|
98% |
| NCT-501 |
++
|
|
98% |
| Gossypol |
✔
|
|
99%+ |
| Devimistat |
✔
|
|
98% |
| Disulfiram |
✔
|
|
98%+ |
| Enasidenib |
++++
|
|
98% |
| PluriSIn 1 |
✔
|
|
99%+ |
| ML390 |
+
|
|
99%+ |
| Teriflunomide |
✔
|
|
99%+ |
| Daidzin |
+++
|
|
98+% |
| 18β-Glycyrrhetinic acid |
✔
|
|
99% |
| RRx-001 |
✔
|
|
95% |
| NCT-503 |
+
|
|
99%+ |
| Vorasidenib |
✔
|
|
99%+ |
| Ammonium Glycyrrhizinate(x:1) |
✔
|
|
98+% |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
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Necroptosis-IN-3 生物活性
| 描述 |
Necroptosis-IN-3 functions as a necroptosis inhibitor targeting TNF-α induced necroptosis [1]. Necroptosis-IN-3 additionally hinders 11β-HSD1 activity [2]. |
| 体外研究 |
TNF-α-IN-8 (0.030-100 μM; 24 h) prevents TNF-α induced necroptosis in FADD-deficient variants of human Jurkat T cells [1]. |
Necroptosis-IN-3 参考文献
Necroptosis-IN-3 实验方案
| 计算器 |
|
| 存储液制备 |
 |
1mg |
5mg |
10mg |
|
1 mM
5 mM
10 mM
|
4.48mL
0.90mL
0.45mL
|
22.39mL
4.48mL
2.24mL
|
44.78mL
8.96mL
4.48mL
|
Necroptosis-IN-3 技术信息
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