There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Parkinson’s disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). MPTP is a neurotoxin that can induce symptoms similar to those observed in PD in humans, nonhuman primates, and mice. In addition, MPTP induces selective loss of dopaminergic neurons in mice SN[3]. Mice in the MPTP group were intraperitoneally injected with 20 mg/kg MPTP hydrochloride dissolved in saline, with four injections at 3-hour intervals over a period of 1 day. The number of tyrosine hydroxylase-immunoreactive neurons in the MPTP group was significantly lower than in the normal group (P < 0.05), indicating successful establishment of the Parkinson's disease model. The changes in thioredoxin reductase 1 protein expression in the midbrain 7 days after the last injection of MPTP were detected. The MPTP-treated mice showed a 40% decrease in thioredoxin reductase 1 protein level compared with the normal mice (P < 0.05). Moreover, there was a pronounced reduction in thioredoxin reductase 1 mRNA level in MPTP-treated mice compared with normal mice (P < 0.05)[4].
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