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Isovaleramide

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Chemical Structure| 541-46-8 同义名 : 异戊酰胺 ;3-Methylbutanamide
CAS号 : 541-46-8
货号 : A959606
分子式 : C5H11NO
纯度 : 98%
分子量 : 101.147
MDL号 : MFCD00014807
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(2471.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Dehydrogenase
描述 Isovaleramide is an active principle on central nervous system from Valeriana pavonii, as an anticonvulsant. Isovaleramide at 100 mg/kg, p.o, evidenced a 90% index protection against the maximal electroshock seizure in mice (MES), comparable to the reference agent: sodium phenytoin (20 mg/kg, p.o, 100%). In the in vitro assay, isovaleramide (300 µM) exhibited a 42% of inhibition of the binding of ³H-FNZ to its sites[3]. Isovaleramide, was essentially uncompetitive inhibitors of purified horse and rat liver alcohol dehydrogenases with respect to ethanol as substrate. The uncompetitive inhibition constants for isovaleramide for rat liver alcohol dehydrogenase was 20 mM, in vitro, whereas in vivo the values was 180 mumol/kg[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

9.89mL

1.98mL

0.99mL

49.43mL

9.89mL

4.94mL

98.87mL

19.77mL

9.89mL
参考文献

[1]Giraldo SE, Rincon J, et al. [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii] .Biomedica. 2010 Apr-Jun;30(2):245-50. Spanish.

[2]Bialer M, Johannessen SI, et al. Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48.

[3]Giraldo SE, Rincón J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF. Isovaleramida, principio anticonvulsivo aislado de Valeriana pavonii [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii]. Biomedica. 2010 Apr-Jun;30(2):245-50. Spanish

[4]Chadha VK, Leidal KG, Plapp BV. Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism. J Med Chem. 1983 Jun;26(6):916-22