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绞股蓝皂苷L /Gypenoside L {[allProObj[0].p_purity_real_show]}

货号:A1327543

Gypenoside L

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Gypenoside L 化学结构 CAS号:94987-09-4
Gypenoside L 化学结构
CAS号:94987-09-4
Gypenoside L 3D分子结构
CAS号:94987-09-4
Gypenoside L 化学结构 CAS号:94987-09-4
Gypenoside L 3D分子结构 CAS号:94987-09-4
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Gypenoside L 纯度/质量文件 产品仅供科研

货号:A1327543 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 ERK ERK1 ERK2 ERK5 其他靶点 纯度
DEL-22379 +

ERK, IC50: 0.5 μM

+

ERK, IC50: 0.5 μM

98%
Pluripotin ++

ERK1, Kd: 98 nM

RasGAP 98+%
FR 180204 +

ERK1, Ki: 0.31 μM

++

ERK2, Ki: 0.14 μM

98%
Ravoxertinib +++

ERK1, IC50: 1.1 nM

++++

ERK2, IC50: 0.3 nM

99%+
SCH772984 +++

ERK1, IC50: 4 nM

++++

ERK2, IC50: 1 nM

99%+
Temuterkib +++

ERK1, IC50: 5 nM

+++

ERK2, IC50: 5 nM

99%+
VX-11e +++

ERK2, Ki: <2 nM

99%+
Ulixertinib ++++

ERK2, IC50: <0.3 nM

99%+
XMD17-109 ++

ERK5, IC50: 162 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 NF-κB 其他靶点 纯度
PDTC ammonium 98%
QNZ ++++

NF-κB, IC50: 11 nM

99%+
Sodium 4-Aminosalicylate Dihydrate 98%
Sodium Salicylate 95%
Parthenolide p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

98%
Phenethyl caffeate 98%
Andrographolide 98+%
Curcumin Nrf2,HDAC 98%
SC75741 +++

NF-κB, EC50: 200 nM

99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 p38 MAPK p38α p38β 其他靶点 纯度
BMS-582949 +++

p38 MAPK, IC50: 13 nM

98%
SB 203580 99%+
Pexmetinib Tie-2 99%+
Skepinone-L ++++

p38α, IC50: 5 nM

98%
Doramapimod ++++

p38α, Kd: 0.1 nM

p38α, IC50: 38 nM

99%+
VX-702 99%+
Ralimetinib dimesylate ++++

p38α, IC50: 7 nM

98%
SB 202190 ++

p38α, IC50: 50 nM

++

p38β, IC50: 100 nM

99%+
Losmapimod ++++

p38α, pKi: 8.1

+++

p38β, pKi: 7.6

99%+
Neflamapimod +++

p38α, IC50: 10 nM

+

p38β, IC50: 220 nM

99%+
PH-797804 ++

p38α, IC50: 26 nM

+

p38β, IC50: 102 nM

99%
TAK-715 ++++

p38α, IC50: 7.1 nM

+

p38β, IC50: 0.20 μM

99%+
SB 239063 ++

p38α, IC50: 44 nM

++

p38β, IC50: 44 nM

99%+
Pamapimod +++

p38α, IC50: 0.014 μM

+

p38β, IC50: 0.48 μM

98%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Gypenoside L 生物活性

描述 Gypenoside L is a saponin isolated from Gynostemma pentaphyllum. It caused cell cycle arrest at S phase, reduced the expression of CDK2, CDK4, CDK6, and cyclin D1, activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators, activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence[1]. It also induced cell death, which was associated with lysosomal swelling and autophagic flux inhibition, increased the levels of ROS, triggered protein ubiquitination and ER stress response, leading to Ca2+ release from ER IP3R-operated stores and finally cell death[2].

Gypenoside L 参考文献

[1]Liao C, Zheng K, Li Y, Xu H, Kang Q, Fan L, Hu X, Jin Z, Zeng Y, Kong X, Zhang J, Wu X, Wu H, Liu L, Xiao X, Wang Y, He Z. Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. Oncotarget. 2016 Jul 26;7(30):47387-47402. doi: 10.18632/oncotarget.10159. PMID: 27329722; PMCID: PMC5216949.

[2]Zheng K, Liao C, Li Y, Fan X, Fan L, Xu H, Kang Q, Zeng Y, Wu X, Wu H, Liu L, Xiao X, Zhang J, Wang Y, He Z. Gypenoside L, Isolated from Gynostemma pentaphyllum, Induces Cytoplasmic Vacuolation Death in Hepatocellular Carcinoma Cells through Reactive-Oxygen-Species-Mediated Unfolded Protein Response. J Agric Food Chem. 2016 Mar 2;64(8):1702-11. doi: 10.1021/acs.jafc.5b05668. Epub 2016 Feb 22. PMID: 26870999.

Gypenoside L 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.25mL

0.25mL

0.12mL

6.24mL

1.25mL

0.62mL

12.48mL

2.50mL

1.25mL

Gypenoside L 技术信息

CAS号94987-09-4
分子式C42H72O14
分子量 801.013
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解方案

DMSO: 105 mg/mL(131.08 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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