Guanfacine HCl is a centrally acting antihypertensive with α2-adrenoceptor agonist with Kd value of 31 nM for α2A-adrenoceptor while displaying 60-fold selectivity over α2B-adrenoceptors, causing a decrease in heart rate and peripheral vascular resistance.
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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Guanfacine hydrochloride, an anti-hypertensive agent. Extended-release guanfacine appears to be safe and effective for reducing hyperactivity, impulsiveness, and distractibility in children with ASD (autism spectrum disorder)[3]. Guanfacine lowers blood pressure by activating CNS alpha adrenoreceptors, which results in sympathetic outflow leading to reduced vascular tone. Guanfacine is rapidly and completely absorbed from the gastrointestinal tract and apparently undergoes extensive distribution to all tissues. Guanfacine's adverse reactions include dry mouth, sedation, and constipation. Adverse effects and reaction to sudden withdrawal of the drug may be less severe with guanfacine than with clonidine[4]. Guanfacine extended release (ER), as a new option to the treatment of attention deficit hyperactivity disorder, which acts at postsynaptic level. Guanfacine stimulates postsynaptic alfa-2A adrenergic receptors so it inhibits the production of cAMP and closes HCN channels enhancing the effectiveness of the signal of the pyramidal neurons of the prefrontal cortex, thus improving working memory and attention[5].
United States, Ohio
... 展开 >>
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45206
United States, Texas
University of Texas Health Science Center
Houston, Texas, United States, 77030 收起 <<
United States, California
... 展开 >>
UCLA Neuropsychiatric Institute
Los Angeles, California, United States, 90024
United States, Connecticut
Yale Child Study Center
New Haven, Connecticut, United States, 06520
United States, Indiana
Indiana University-Riley Hospital for Children
Indianapolis, Indiana, United States, 46202
United States, Maryland
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21231
United States, Ohio
Ohio State University
Columbus, Ohio, United States, 43210 收起 <<
United States, New York
... 展开 >>
New York State Psychiatric Institute
Recruiting
New York, New York, United States, 10032
Contact: Jonathan Posner, MD 646-774-5735 PosnerJ@nyspi.columbia.edu
Principal Investigator: Jonathan Posner, MD 收起 <<
United States, Massachusetts
... 展开 >>
Center for Translational Pain Research
Recruiting
Boston, Massachusetts, United States, 02114
Contact: Sarah Roth, B.S 617-724-6102 sroth3@mgh.harvard.edu
Principal Investigator: Jianren Mao, M.D., Ph.D. 收起 <<
United States, Connecticut
... 展开 >>
Alzheimer's Disease Research Unit, Yale University School of Medicine
New Haven, Connecticut, United States, 06510 收起 <<
United States, New York
... 展开 >>
Bronx VA Medical Center
Bronx, New York, United States, 10468
Mount Sinai Medical Center
NY, New York, United States, 10029
Pilgrim Psychiatric Center
W. Brentwood, New York, United States, 11717 收起 <<
United Kingdom
... 展开 >> Institute of Psychiatry, Psychology & Neuroscience; King's College London
Not yet recruiting
London, United Kingdom, SE5 8AF
Contact: Olivia S Kowalczyk, BSc 02078480384 oliwia.s.kowalczyk@kcl.ac.uk
Principal Investigator: Olivia S Kowalczyk, BSc
Sub-Investigator: Katya Rubia, PhD
Sub-Investigator: Mitul A Mehta, PhD 收起 <<
United States, Connecticut
... 展开 >>
Connecticut Mental Health Center
New Haven, Connecticut, United States, 06511
Yale Magnetic Resonance Research Center
New Haven, Connecticut, United States, 06520
Veterans Affairs Hospital
West Haven, Connecticut, United States, 06516 收起 <<
United States, California
... 展开 >>
University of California, Los Angeles
Los Angeles, California, United States, 90024
United States, Connecticut
Yale University
New Haven, Connecticut, United States, 06519
United States, Georgia
Emory University
Atlanta, Georgia, United States, 30329
United States, Massachusetts
Massachusetts General Hospital
Lexington, Massachusetts, United States, 02142
United States, Washington
Seattle Children's Hospital
Seattle, Washington, United States, 98101 收起 <<
United States, Connecticut
... 展开 >>
Yale Child Study Center
New Haven, Connecticut, United States, 06510
United States, Florida
University of South Florida
Tampa, Florida, United States, 33612
United States, New York
Mount Sinai School of Medicine
New York, New York, United States, 10029 收起 <<
Postoperative Nausea and Vomit... 展开 >>ing
Pain, Postoperative 收起 <<
Not Applicable
Unknown
July 2017
United States, Tennessee
... 展开 >>
Vanderbilt University Medical Center
Recruiting
Nashville, Tennessee, United States, 37212
Principal Investigator: Stephen Harvey, MD 收起 <<
United States, Texas
... 展开 >>
Dept. Of Psychiatry, University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229-3900 收起 <<
Terminated(extended beyond com... 展开 >>pletion date; chose to close out rather than renew IRB review) 收起 <<
-
United States, New Jersey
... 展开 >>
Children's Specialized Hospital
Hamilton, New Jersey, United States, 08619
Children's Specialized Hospital
Toms River, New Jersey, United States, 08755 收起 <<
United States, Connecticut
... 展开 >>
Yale Center for Clinical Investigations, Yale University
Recruiting
New Haven, Connecticut, United States, 06519
Contact: Paula Cunningham 203-737-3554
Principal Investigator: Sherry A McKee, PhD 收起 <<
United States, Massachusetts
... 展开 >>
MGH Center for Translational Pain Research
Recruiting
Boston, Massachusetts, United States, 02114
Contact: MGH Center for Translational Pain Research 617-724-6102 mghpainresearch@partners.org
Principal Investigator: Jianren Mao, M.D., Ph.D. 收起 <<
United States, New York
... 展开 >>
The Clinical Research Center
Recruiting
East Setauket, New York, United States, 11794
Contact: Antoinette Funaro, MS 631-638-0057 antoinette.funaro@stonybrookmedicine.edu
Putnam Hall Outpatient Facility
Recruiting
Stony Brook, New York, United States, 11794
Contact: David Schlager, MD 631-444-2571 david.schlager@stonybrookmedicine.edu 收起 <<
United States, Connecticut
... 展开 >>
Yale University School of Medicine
Not yet recruiting
New Haven, Connecticut, United States, 06519
Contact: Meaghan Lavery 203-737-2783 meaghan.lavery@yale.edu
Contact: Sabrina Coppola 203-737-2827 sabrina.coppola@yale.edu
Principal Investigator: Sherry McKee, PhD 收起 <<
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