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Guanfacine HCl is a centrally acting antihypertensive with α2-adrenoceptor agonist with Kd value of 31 nM for α2A-adrenoceptor while displaying 60-fold selectivity over α2B-adrenoceptors, causing a decrease in heart rate and peripheral vascular resistance.
Bezafibrate is the agonist of PPAR and the EC50 for PPAR⍺, PPARβ, PPARẟ is 50 , 20, and 60 nM respectively. It has hypolipidemic effect.
Clofibrate, a fibric acid derivative, is a selective agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50 of 50 µM. Clofibrate has been used to treat hyperlipoproteinemia type III and severe hypertriglyceridemia.
Lovastatin是一种用于降低胆固醇的细胞渗透性 HMG-CoA 还原酶抑制剂。
Haloperidol 是一种典型的抗精神病药,对 D2 多巴胺受体具有高亲和力。Haloperidol 具有抗精神病作用,主要用于精神分裂症和其他精神障碍的治疗。
Atorvastatin Calcium Salt Trihydrate是一种广泛使用的降胆固醇药物,主要通过抑制HMG-CoA还原酶来降低血清胆固醇水平。它用于治疗高胆固醇血症和相关心血管疾病。
Fenofibrate is an agonist of PPARα (EC50 = 30 μM) and an inhibitor of CYP2C19 (IC50 = 0.2 μM) and CYP2B6 (IC50 = 0.7 μM). Fenofibrate is a fibric acid derivative and used to treat hypercholesterolemia and hypertriglyceridemia.
Nicotinic acid is a water-soluble vitamin and is part of the vitamin B group.
Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2.
Tags: 降血脂 | Reduce Blood Lipid | 小分子阳性药 | Small Molecule Positive Drug | 降血脂 相关产品
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