Maprotiline HCl is a bridged-ring tetracyclic antidepressant with adrenergic activity and sedative properties, exerting its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors.
Maprotiline (Hydrochloride), selective NA reuptake inhibitor, a tetracyclic antidepressant with sedative properties, exhibits strong inhibitory effects on norepinephrine uptake across nerve cell membranes but interferes relatively little with serotoninergic mechanisms[3]. Maprotiline bounds to the full-length recombinant sGC (Soluble guanylate cyclase) with a high affinity (KD = 0.307 μM). Moreover, in a monocrotaline rat model of PAH (Pulmonary arterial hypertension), maprotiline (ip, 10 mg/kg once daily) reduced pulmonary hypertension, inhibited the development of right ventricular hypertrophy and pathological changes of the pulmonary vascular remodeling[4].
China, Beijing
... 展开 >> The Third Affiliated Hospital of Beijing University of Chinese Medicine
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China, Beijing
... 展开 >> The Third Affiliated Hospital of Beijing University of Chinese Medicine
Recruiting
Beijing, Beijing, China, 100029
Contact: Wenjun Sun, MD, PHD +86 18910259376 doctorsunwenjun@126.com 收起 <<
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