Zenidolol hydrochloride
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货号：A136388
同义名：
ICI-118551 Hydrochloride;ICI 118551 (hydrochloride)
ICI 118551 HCl is a selective and inverse β2 adrenergic receptor antagonist with Ki values of 1.2, 120 and 257nM for β2, β1 and β3 receptors, respectively.
Zenidolol hydrochloride 化学结构
Zenidolol hydrochloride 3D分子结构
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Zenidolol hydrochloride 纯度/质量文件 产品仅供科研
货号：A136388
标准纯度：
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产品说明书
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Zenidolol hydrochloride 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
96%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2B-adrenergic receptor, pKi: 8.9
α2A-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2A, pKi: 7.1
adrenoceptor α2C, pKi: 7.2
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1A-adrenergic receptor, Ki: 3.7 nM
α1D-adrenergic receptor, Ki: 20 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
99%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
99%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Zenidolol hydrochloride 生物活性
靶点
β-adrenergic receptor
β1-adrenergic receptor, Ki:611nM
β2-adrenergic receptor, Ki:0.7nM
描述
ICI 118551 (Hydrochloride) is a highly selective β2 adrenergic receptor antagonist. ICI 118551 inhibits cAMP accumulation by 50% with IC50 of 1.7 μM in IMCD cells[3] [4] [5]
Zenidolol hydrochloride 参考文献
[1] Wenzel D, Knies R, et al. beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway. Hypertension. 2009 Jul;54(1):157-63.
[2] Yasuda G, Sun L, et al. The beta 1- and beta 2-adrenoceptor subtypes in cultured rat inner medullary collecting duct cells. Am J Physiol. 1996 Sep;271(3 Pt 2):F762-9.
[3] Yasuda G, Sun L, Lee HC, Umemura S, Jeffries WB. The beta 1- and beta 2-adrenoceptor subtypes in cultured rat inner medullary collecting duct cells. Am J Physiol. 1996 Sep;271(3 Pt 2):F762-9. doi: 10.1152/ajprenal.1996.271.3.F762. PMID: 8853440.
[4] Gong H, Sun H, Koch WJ, Rau T, Eschenhagen T, Ravens U, Heubach JF, Adamson DL, Harding SE. Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart. Circulation. 2002 May 28;105(21):2497-503. doi: 10.1161/01.cir.0000017187.61348.95. PMID: 12034656.
[5] Wenzel D, Knies R, Matthey M, Klein AM, Welschoff J, Stolle V, Sasse P, Röll W, Breuer J, Fleischmann BK. beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway. Hypertension. 2009 Jul;54(1):157-63. doi: 10.1161/HYPERTENSIONAHA.109.130468. Epub 2009 May 26. PMID: 19470879.
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Zenidolol hydrochloride 实验方案
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摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.19mL
0.64mL
0.32mL
15.93mL
3.19mL
1.59mL
31.86mL
6.37mL
3.19mL
Zenidolol hydrochloride 技术信息
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