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首页 / 抑制剂/激动剂 / 膜转运蛋白 / 钠通道 / Flecainide

Flecainide {[allProObj[0].p_purity_real_show]}

货号：A879202 Ambeed 开学季，买赠积分，赢豪礼

Flecainide acetate, a class Ic antiarrhythmic agent, can block the Nav1.5 sodium channel and inhibit ryanodine receptor 2 (RyR2). It is used to prevent and treat tachyarrhythmias.

Flecainide 化学结构 CAS号：54143-55-4
Flecainide 化学结构
CAS号：54143-55-4
Flecainide 3D分子结构
CAS号：54143-55-4
Flecainide 化学结构 CAS号：54143-55-4
Flecainide 3D分子结构 CAS号：54143-55-4
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Flecainide 纯度/质量文件 产品仅供科研

货号：A879202 标准纯度： {[allProObj[0].p_purity_real_show]}
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产品名称 Sodium Channel ↓ 其他靶点 纯度
Tolperisone HCl ✔ {[allProObj[0].p_purity_real_show]}
Lamotrigine ✔ {[allProObj[0].p_purity_real_show]}
Vinpocetine ✔ {[allProObj[0].p_purity_real_show]}
Zonisamide ✔ {[allProObj[0].p_purity_real_show]}
Dronedarone Hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Procainamide hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Bupivacaine HCl ✔ {[allProObj[0].p_purity_real_show]}
Benzocaine ✔ {[allProObj[0].p_purity_real_show]}
Carbamazepine ++

Sodium channel, IC50: 131 μM

 		{[allProObj[0].p_purity_real_show]}
Ibutilide fumarate ✔ {[allProObj[0].p_purity_real_show]}
Dibucaine HCl ✔ {[allProObj[0].p_purity_real_show]}
Mexiletine HCl ✔ {[allProObj[0].p_purity_real_show]}
Phenytoin ✔ {[allProObj[0].p_purity_real_show]}
Camostat Mesylate +++

epithelial sodium channel (ENaC), IC50: 50 nM

 		{[allProObj[0].p_purity_real_show]}
Levobupivacaine ✔ {[allProObj[0].p_purity_real_show]}
Oxcarbazepine +

sodium channel, IC50: 160 μM

 		{[allProObj[0].p_purity_real_show]}
Ambroxol {[allProObj[0].p_purity_real_show]}
Primidone ✔ {[allProObj[0].p_purity_real_show]}
Propafenone ✔ {[allProObj[0].p_purity_real_show]}
A-803467 ++++

Na(V1.8) channel, IC50: 8 nM

 		{[allProObj[0].p_purity_real_show]}
Rufinamide ✔ {[allProObj[0].p_purity_real_show]}
Phenytoin sodium ✔ {[allProObj[0].p_purity_real_show]}
Proparacaine Hydrochloride +

Voltage-gated sodium channel, ED50: 3.4 mM

 		{[allProObj[0].p_purity_real_show]}
Riluzole ✔ {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Flecainide 生物活性

描述 Flecainide is a class 1c antiarrhythmic that acts by blocking sodium channels to reduce intracardiac conduction and is used mainly in the treatment of supraventricular arrhythmias[3]. Its primary electrophysiologic effect is a slowing of conduction in a wide range of cardiac tissues. It is well absorbed and effective in suppressing isolated premature ventricular contractions (PVCs) or nonsustained ventricular arrhythmia but has only a modest efficacy when electrophysiologic testing is used as an endpoint[4]. Intravenous flecainide cardioversion could be a safe and effective option for emergency physicians to restore sinus rhythm in selected patients with acute AF (Atrial fibrillation) [5]. Flecainide is a well-tolerated medication, even at 12 months, with very minor adverse effects[6]. Administered during preexcited atrial fibrillation, flecainide consistently slows the ventricular response and converts the majority of cases to sinus rhythm. Serious ventricular proarrhythmia is seen almost exclusively in patients with structural cardiac disease[7].

Flecainide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00578617 Atrial Fibrillation ... 展开 >> Arrhythmia 收起 << Not Applicable Completed - United States, Alabama ... 展开 >> Universtity of Alabama Hospital Birminham, Alabama, United States, 35233 United States, California Good Samaritan Hospital Los Angeles, California, United States, 90017 United States, Illinois Loyola University Maywood, Illinois, United States, 60626 United States, Iowa Mercy Medical Center Des Moines, Iowa, United States, 50314 United States, Maryland Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, Massachusetts Brigham and Womens Hospital Boston, Massachusetts, United States, 02115 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55902 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pennsylvania Health Philadelphia, Pennsylvania, United States, 19104 United States, Utah Intermountain Medical Center Murray, Utah, United States, 84157 收起 <<
NCT03737929 Atrial Fibrillation Not Applicable Not yet recruiting January 2022 France ... 展开 >> CHU Toulouse, Hôpital Rangueil Not yet recruiting Toulouse, France, 31059 Contact: Philippe Maury, MD    05 61 32 34 56 ext +33    maury.p@chu-toulouse.fr    Contact: Anne Rollin, MD       rollin.a@chu-toulouse.fr    Principal Investigator: Philippe Maury, MD          Sub-Investigator: Anne Rollin, MD          Sub-Investigator: Bertrand Marcheix, MD          Sub-Investigator: Etienne Grunenwald, MD 收起 <<
NCT00578617 - Completed - -

Flecainide 参考文献

[1]Park SB, Vucic S, et al. Flecainide in Amyotrophic Lateral Sclerosis as a Neuroprotective Strategy (FANS): A Randomized Placebo-Controlled Trial. EBioMedicine. 2015 Dec 1;2(12):1916-22.

[2]Apostolakis S, Oeff M, et al. Flecainide acetate for the treatment of atrial and ventricular arrhythmias. Expert Opin Pharmacother. 2013 Feb;14(3):347-57.

[3]Velasco SL, Sierra-Hidalgo F, Rodríguez RM, Guerreo AJ, Morales JR. Flecainide-induced myoclonus. Clin Neuropharmacol. 2014 Mar-Apr;37(2):65-6

[4]Falk RH, Fogel RI. Flecainide. J Cardiovasc Electrophysiol. 1994 Nov;5(11):964-81

[5]Markey GC, Salter N, Ryan J. Intravenous Flecainide for Emergency Department Management of Acute Atrial Fibrillation. J Emerg Med. 2018 Mar;54(3):320-327

[6]Muzzey M, Tellor KB, Ramaswamy K, Schwarze M, Armbruster AL. Flecainide is well-tolerated and effective in patient with atrial fibrillation at 12 months: a retrospective study. Ther Adv Cardiovasc Dis. 2020 Jan-Dec;14:1753944720926824

[7]Crozier I. Flecainide in the Wolff-Parkinson-White syndrome. Am J Cardiol. 1992 Aug 20;70(5):26A-32A

Flecainide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.07mL

2.41mL

1.21mL

24.13mL

4.83mL

2.41mL

Flecainide 技术信息

CAS号54143-55-4
分子式C17H20F6N2O3
分子量 414.34
别名
运输蓝冰
存储条件

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(253.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Flecainide | 54143-55-4 | Membrane Transporter/Ion Channel | Potassium Channel | Sodium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Flecainide 纯度/质量文件 | Flecainide 亚型比较 | Flecainide 生物活性 | Flecainide 临床数据 | Flecainide 参考文献 | Flecainide 实验方案 | Flecainide 技术信息

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