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首页 / 抑制剂/激动剂 / 膜转运蛋白 / 钠通道 / Flecainide acetate

氟卡胺 /Flecainide acetate {[allProObj[0].p_purity_real_show]}

货号：A555383 同义名： 醋酸洗必太 / R-818;Flecainide (acetate) Ambeed 开学季，买赠积分，赢豪礼

Flecainide Acetate is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia and works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

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Flecainide acetate 化学结构 CAS号：54143-56-5
Flecainide acetate 化学结构
CAS号：54143-56-5
Flecainide acetate 3D分子结构
CAS号：54143-56-5
Flecainide acetate 化学结构 CAS号：54143-56-5
Flecainide acetate 3D分子结构 CAS号：54143-56-5
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Flecainide acetate 纯度/质量文件 产品仅供科研

货号：A555383 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Sodium Channel ↓ 其他靶点 纯度
Tolperisone HCl ✔ {[allProObj[0].p_purity_real_show]}
Lamotrigine ✔ {[allProObj[0].p_purity_real_show]}
Vinpocetine ✔ {[allProObj[0].p_purity_real_show]}
Zonisamide ✔ {[allProObj[0].p_purity_real_show]}
Dronedarone Hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Procainamide hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Bupivacaine HCl ✔ {[allProObj[0].p_purity_real_show]}
Benzocaine ✔ {[allProObj[0].p_purity_real_show]}
Carbamazepine ++

Sodium channel, IC50: 131 μM

 		{[allProObj[0].p_purity_real_show]}
Ibutilide fumarate ✔ {[allProObj[0].p_purity_real_show]}
Dibucaine HCl ✔ {[allProObj[0].p_purity_real_show]}
Mexiletine HCl ✔ {[allProObj[0].p_purity_real_show]}
Phenytoin ✔ {[allProObj[0].p_purity_real_show]}
Camostat Mesylate +++

epithelial sodium channel (ENaC), IC50: 50 nM

 		{[allProObj[0].p_purity_real_show]}
Levobupivacaine ✔ {[allProObj[0].p_purity_real_show]}
Oxcarbazepine +

sodium channel, IC50: 160 μM

 		{[allProObj[0].p_purity_real_show]}
Ambroxol {[allProObj[0].p_purity_real_show]}
Primidone ✔ {[allProObj[0].p_purity_real_show]}
Propafenone ✔ {[allProObj[0].p_purity_real_show]}
A-803467 ++++

Na(V1.8) channel, IC50: 8 nM

 		{[allProObj[0].p_purity_real_show]}
Rufinamide ✔ {[allProObj[0].p_purity_real_show]}
Phenytoin sodium ✔ {[allProObj[0].p_purity_real_show]}
Proparacaine Hydrochloride +

Voltage-gated sodium channel, ED50: 3.4 mM

 		{[allProObj[0].p_purity_real_show]}
Riluzole ✔ {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Flecainide acetate 生物活性

描述 Flecainide Acetate is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia and works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

Flecainide acetate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03737929 Atrial Fibrillation Not Applicable Not yet recruiting January 2022 France ... 展开 >> CHU Toulouse, Hôpital Rangueil Not yet recruiting Toulouse, France, 31059 Contact: Philippe Maury, MD    05 61 32 34 56 ext +33    maury.p@chu-toulouse.fr    Contact: Anne Rollin, MD       rollin.a@chu-toulouse.fr    Principal Investigator: Philippe Maury, MD          Sub-Investigator: Anne Rollin, MD          Sub-Investigator: Bertrand Marcheix, MD          Sub-Investigator: Etienne Grunenwald, MD 收起 <<
NCT02248753 Atrial Fibrillation Not Applicable Active, not recruiting October 2019 Netherlands ... 展开 >> VU University Medical Center Amsterdam, Netherlands Amphia Hospital Breda, Netherlands Catharina Ziekenhuis Eindhoven, Netherlands Medisch Spectrum Twente Enschede, Netherlands University Medical Center Groningen Groningen, Netherlands Zuyderland Medical Center Heerlen, Netherlands Alrijne Hospital Leiderdorp, Netherlands Maastricht University Medical Center Maastricht, Netherlands St. Antonius Hospital Nieuwegein, Netherlands Franciscus Gasthuis Rotterdam, Netherlands Antonius Ziekenhuis Sneek, Netherlands HagaZiekenhuis The Hague, Netherlands St. Elisabeth - TweeSteden Hospital Tilburg, Netherlands Diakonessenhuis Utrecht, Netherlands VieCuri Medical Center Venlo, Netherlands 收起 <<
NCT00578617 - Completed - -

Flecainide acetate 参考文献

[1]Kohli V. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65(2):168-71.

[2]Desaphy JF, De Luca A, et al. Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554(Pt 2):321-34. Epub 2003 Nov 7. Erratum in: J Physiol. 2004 Mar 16;555(Pt 3):851. Luca, Annamaria D E [corrected to De Luca, Annamaria] .

Flecainide acetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.11mL

0.42mL

0.21mL

10.54mL

2.11mL

1.05mL

21.08mL

4.22mL

2.11mL

Flecainide acetate 技术信息

CAS号54143-56-5
分子式C19H24F6N2O5
分子量 474.395
别名 醋酸洗必太 ;R-818;Flecainide (acetate)
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 50 mg/mL(105.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(42.16 mM)，配合低频超声助溶
动物实验配方

Tags: Flecainide | 54143-56-5 | R-818 | R818 | R 818 | Sodium Channel Inhibitor | Membrane Transporter/Ion Channel | Sodium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Flecainide acetate 纯度/质量文件 | Flecainide acetate 亚型比较 | Flecainide acetate 生物活性 | Flecainide acetate 临床数据 | Flecainide acetate 参考文献 | Flecainide acetate 实验方案 | Flecainide acetate 技术信息

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