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Eniluracil
Eniluracil
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货号：A208918
Enil urac il 是一种口服有效的二氢嘧啶脱氢酶 (DPD) 抑制剂，能够不可逆地抑制 DPD，显著提高 5-氟尿嘧啶 (5-FU) 的口服生物利用度。Enil urac il 也作为点击化学试剂，参与铜催化的叠氮-炔环加成反应 (CuAAc )，适用于 5-FU 联合抗癌治疗的研究。
Eniluracil 化学结构
Eniluracil 3D分子结构
规格
价格
会员价
库存
数量
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Eniluracil 纯度/质量文件 产品仅供科研
货号：A208918
标准纯度：
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产品说明书
全球学术期刊中引用的产品
• Nat. Biomed. Eng. , 2024, 8, 1412-1424. Ambeed. A538667 ,
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• J. Am. Soc. Mass Spectrom. , 2024, 35(12): 3192-3202. Ambeed. A961334 ,
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• PloS One , 2024, 19(11): e0308060. Ambeed. 更多 >
Eniluracil 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132H-IDH1, IC50: 70 nM
R132C-IDH1, IC50: 0.16 μM
99%+
SW033291
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
98%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase I, IC50: 39 nM
Inosine monophosphate dehydrogenase II, IC50: 27 nM
98%
MK-8245
++++
SCD1 (mouse), IC50: 1 nM
SCD1 (rat), IC50: 3 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Eniluracil 生物活性
描述
Eniluracil, also known as 5-Ethynyluracil, is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor. Eniluracil irreversibly inhibits DPD, increases the oral bioavailability of 5-fluorouracil to 100% and promotes the homogeneous absorption and toxicity of 5-fluorouracil. Eniluracil can be used in combination with fluoropyrimidines (e.g., 5-fluorouracil) in combination for cancer research[1] [2]
Eniluracil 动物研究
Animal study
Administered intraperitoneally at a dose of 1 mg/kg once daily for 3 days, Eniluracil greatly improves 5-fluorouracil treatment in rats[1]
Eniluracil 参考文献
Eniluracil 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
7.35mL
1.47mL
0.73mL
36.74mL
7.35mL
3.67mL
73.47mL
14.69mL
7.35mL
Eniluracil 技术信息
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