Eniluracil, also known as 5-Ethynyluracil, is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor. Eniluracil irreversibly inhibits DPD, increases the oral bioavailability of 5-fluorouracil to 100% and promotes the homogeneous absorption and toxicity of 5-fluorouracil. Eniluracil can be used in combination with fluoropyrimidines (e.g., 5-fluorouracil) in combination for cancer research[1][2].Eniluracil contains an alkyne group that can undergo copper-catalysed azide-alkyne cycloaddition (CuAAc) with molecules containing an azide moiety, and can therefore be used as a click chemistry reagent.
Eniluracil 动物研究
Animal study
Administered intraperitoneally at a dose of 1 mg/kg once daily for 3 days, Eniluracil greatly improves 5-fluorouracil treatment in rats[1].
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