Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 / 抑制剂/激动剂 / 膜转运蛋白 / 钠通道 / Dyclonine HCl

盐酸达克罗宁 /Dyclonine HCl {[allProObj[0].p_purity_real_show]}

货号：A162451 同义名： Dyclocaine hydrochloride;Dyclonine (hydrochloride)

Dyclonine HCl is the HCl form of dyclonine which can reversibly bind to activated sodium channels on the neuronal membrane. It is an anaesthetic found in sucrets.

Dyclonine HCl 化学结构 CAS号：536-43-6
Dyclonine HCl 化学结构
CAS号：536-43-6
Dyclonine HCl 3D分子结构
CAS号：536-43-6
Dyclonine HCl 化学结构 CAS号：536-43-6
Dyclonine HCl 3D分子结构 CAS号：536-43-6
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Dyclonine HCl 纯度/质量文件 产品仅供科研

货号：A162451 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Cell Host Microbe, 2024. Ambeed. [ A163338 ]
• Cancer Res., 2024. Ambeed. [ A295334 ]
• J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]
• J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]
• JBC, 2024, 107935. Ambeed. [ A194396 ]
更多 >
产品名称 Sodium Channel ↓ 其他靶点 纯度
Tolperisone HCl ✔ 99%
Lamotrigine ✔ 98%
Vinpocetine ✔ 98%
Zonisamide ✔ 98%
Dronedarone Hydrochloride ✔ 95%
Procainamide hydrochloride ✔ 99%
Bupivacaine HCl ✔ 99+%
Benzocaine ✔ 98%
Carbamazepine ++

Sodium channel, IC50: 131 μM

 		98%
Ibutilide fumarate ✔ 99%+
Dibucaine HCl ✔ 99+%
Mexiletine HCl ✔ 99%
Phenytoin ✔ 99+%
Camostat Mesylate +++

epithelial sodium channel (ENaC), IC50: 50 nM

 		99%+
Levobupivacaine ✔ 97+%
Oxcarbazepine +

sodium channel, IC50: 160 μM

 		98%
Ambroxol 98+%
Primidone ✔ 99%
Propafenone ✔ 99%
A-803467 ++++

Na(V1.8) channel, IC50: 8 nM

 		99%+
Rufinamide ✔ 99%
Phenytoin sodium ✔ 98%
Proparacaine Hydrochloride +

Voltage-gated sodium channel, ED50: 3.4 mM

 		98+%
Riluzole ✔ 97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Dyclonine HCl 生物活性

描述 Dyclonine hydrochloride is the hydrochloride salt of Dyclonine. It reversibly binds to activated sodium channels in the neuron membrane, thereby decreasing the neuronal membrane’s permeability to sodium ions. This results in a transient and reversible loss of sensation in a localized area of body. It is recently reported to act as a covalent inhibitor for aldehyde dehydrogenases (ALDHs). Dyclonine hydrochloride (50 µM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH. Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo. Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine[3].

Dyclonine HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03352700 Bowel Preparation Scale ... 展开 >> the Amount of Air Bubble Adenoma Detection Rate 收起 << Phase 4 Not yet recruiting February 1, 2018 China ... 展开 >> Changhai Hospital, Second Military Medical University Shanghai, China, 200433 收起 <<

Dyclonine HCl 参考文献

[1]Gargiulo AV, Burns GM, Huck CP. Dyclonine hydrochloride--a topical agent for managing pain. Ill Dent J. 1992 Jul-Aug;61(4):303-4.

[2]Florestano HJ, Bahler ME. Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc (Baltim), 1956. 45(5): p. 320-5.

[3]Okazaki S, Shintani S, Hirata Y, et al. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget. 2018;9(73):33832-33843.

Dyclonine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.07mL

0.61mL

0.31mL

15.34mL

3.07mL

1.53mL

30.69mL

6.14mL

3.07mL

Dyclonine HCl 技术信息

CAS号536-43-6
分子式C18H28ClNO2
分子量 325.873
别名 Dyclocaine hydrochloride;Dyclonine (hydrochloride);Tanaclone;Dyclothane;Dyclone;Dyclocaine HCl;Dyclonine hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 25 mg/mL(76.72 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(153.43 mM)，配合低频超声助溶
动物实验配方

Tags: Dyclonine | 536-43-6 | Dyclocaine | ALDH Inhibitor/Local Anaesthetic | Anti-infection | Metabolic Enzyme/Protease | Bacterial | Fungal | Aldehyde Dehydrogenase (ALDH) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Dyclonine HCl 纯度/质量文件 | Dyclonine HCl 亚型比较 | Dyclonine HCl 生物活性 | Dyclonine HCl 临床数据 | Dyclonine HCl 参考文献 | Dyclonine HCl 实验方案 | Dyclonine HCl 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z