Dyclonine HCl is the HCl form of dyclonine which can reversibly bind to activated sodium channels on the neuronal membrane. It is an anaesthetic found in sucrets.
Dyclonine hydrochloride is the hydrochloride salt of Dyclonine. It reversibly binds to activated sodium channels in the neuron membrane, thereby decreasing the neuronal membrane’s permeability to sodium ions. This results in a transient and reversible loss of sensation in a localized area of body. It is recently reported to act as a covalent inhibitor for aldehyde dehydrogenases (ALDHs). Dyclonine hydrochloride (50 µM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH. Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo. Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine[3].
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