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Detomidine HCl
盐酸地托咪定 /Detomidine HCl
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货号：A142754
同义名：
地托咪定盐酸盐
/ Detomidine (hydrochloride);MPV 253AII
Detomidine HCl is an imidazole-derived α2-adrenergic agonist, used in veterinary medicine for sedation of large animals.
Detomidine HCl 化学结构
Detomidine HCl 3D分子结构
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Detomidine HCl 纯度/质量文件 产品仅供科研
货号：A142754
标准纯度：
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产品说明书
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Detomidine HCl 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
98%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2B-adrenergic receptor, pKi: 8.9
α2A-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2A, pKi: 7.1
adrenoceptor α2C, pKi: 7.2
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1D-adrenergic receptor, Ki: 20 nM
α1A-adrenergic receptor, Ki: 3.7 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
97%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
98%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Detomidine HCl 生物活性
描述
Detomidine Hydrochloride is an imidazole derivative and α2-adrenergic agonist used as a large animal sedative[3] [4] [5]
Detomidine HCl 参考文献
[1] Lizarraga I, Castillo-Alcala F, et al. Sedation and mechanical hypoalgesia after sublingual administration of detomidine hydrochloride gel to donkeys. J Am Vet Med Assoc. 2016 Jul 1;249(1):83-9.
[2] Laine E, Tuominen V, et al. Physical studies of detomidine hydrochloride, a new drug substance. Acta Pharm Suec. 1983;20(6):451-60.
[3] Virtanen R, Ruskoaho H, Nyman L. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7.
[4] de Moura RS, Bittar IP, da Silva LH, Villela ACV, Dos Santos Júnior MB, Borges NC, Franco LG. Sedative and cardiorespiratory effects of detomidine constant rate infusion in sheep. Lab Anim. 2018 Feb;52(1):51-58.
[5] Lizarraga I, Castillo-Alcala F, Varner KM, Robinson LS. Sedation and mechanical hypoalgesia after sublingual administration of detomidine hydrochloride gel to donkeys. J Am Vet Med Assoc. 2016 Jul 1;249(1):83-9.
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Detomidine HCl 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.49mL
0.90mL
0.45mL
22.45mL
4.49mL
2.25mL
44.90mL
8.98mL
4.49mL
Detomidine HCl 技术信息
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