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Detomidine HCl

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Chemical Structure| 90038-01-0 同义名 : 地托咪定盐酸盐 ;Detomidine (hydrochloride);MPV 253AII;Domosedan;Detomidine hydrochloride
CAS号 : 90038-01-0
货号 : A142754
分子式 : C12H15ClN2
纯度 : 98%
分子量 : 222.71
MDL号 : MFCD17292784
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(471.46 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(89.8 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Detomidine Hydrochloride is an imidazole derivative and α2-adrenergic agonist used as a large animal sedative[3]. Eight adult female Santa Inês sheep received 20 µg/kg of detomidine hydrochloride intravenously as a bolus loading dose, followed by an infusion rate of 60 µg/kg/h. The heart rates and respiratory rates changed continuously during the CRI (constant rate infusion) period[4]. Sublingual administration of detomidine gel at 40 μg/kg may be useful for sedation of standing donkeys prior to potentially painful minor procedures[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.49mL

0.90mL

0.45mL

22.45mL

4.49mL

2.25mL

44.90mL

8.98mL

4.49mL
参考文献

[1]Lizarraga I, Castillo-Alcala F, et al. Sedation and mechanical hypoalgesia after sublingual administration of detomidine hydrochloride gel to donkeys. J Am Vet Med Assoc. 2016 Jul 1;249(1):83-9.

[2]Laine E, Tuominen V, et al. Physical studies of detomidine hydrochloride, a new drug substance. Acta Pharm Suec. 1983;20(6):451-60.

[3]Virtanen R, Ruskoaho H, Nyman L. Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic. J Vet Pharmacol Ther. 1985 Mar;8(1):30-7.

[4]de Moura RS, Bittar IP, da Silva LH, Villela ACV, Dos Santos Júnior MB, Borges NC, Franco LG. Sedative and cardiorespiratory effects of detomidine constant rate infusion in sheep. Lab Anim. 2018 Feb;52(1):51-58.

[5]Lizarraga I, Castillo-Alcala F, Varner KM, Robinson LS. Sedation and mechanical hypoalgesia after sublingual administration of detomidine hydrochloride gel to donkeys. J Am Vet Med Assoc. 2016 Jul 1;249(1):83-9.