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Deoxycorticosterone Acetate
乙酸去氧皮质酮 /Deoxycorticosterone Acetate
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货号：A947730
同义名：
醋酸去氧皮质酮
/ 11-Deoxycorticosterone acetate;DOC acetate
Deoxycorticosterone acetate is a corticosteroid hormone which can induce hypertension dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.
Deoxycorticosterone Acetate 化学结构
Deoxycorticosterone Acetate 3D分子结构
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Deoxycorticosterone Acetate 纯度/质量文件 产品仅供科研
货号：A947730
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Deoxycorticosterone Acetate 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
98%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2A-adrenergic receptor, pKi: 8.9
α2B-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2A, pKi: 7.1
adrenoceptor α2C, pKi: 7.2
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1A-adrenergic receptor, Ki: 3.7 nM
α1D-adrenergic receptor, Ki: 20 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
97%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
98%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Deoxycorticosterone Acetate 生物活性
描述
Deoxycorticosterone acetate (DOCA) is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. Myocardial stiffness was increased and left ventricular compliance significantly diminished in the DOCA control group, and these changes were attenuated by epicatechin treatment[3] [4] [5]
Deoxycorticosterone Acetate 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT01186484
Prostatic Neoplasms
Phase 1
Completed
-
Japan
... 展开 >>
Fukuoka, Japan
Kashiwa, Japan
Koto-Ku, Japan
Sunto, Japan
Yokohama, Japan 收起 <<
NCT03082339
-
Recruiting
March 31, 2018
Germany
... 展开 >> University Giessen
Recruiting
Gießen, Germany, 35394
Contact: Matthias Hecker, MD
Neurologische Klinik Bad Salzhausen
Recruiting
Nidda, Germany, 63667
Contact: Dirk Bandorski, MD
Contact: Jens Allendörfer, MD 收起 <<
Deoxycorticosterone Acetate 参考文献
[1] Borde P, Mohan M, et al. Effect of myricetin on deoxycorticosterone acetate (DOCA)-salt-hypertensive rats. Nat Prod Res. 2011 Sep;25(16):1549-59.
[2] Underwood KA, McCutcheon NB, et al. The effects of fludrocortisone acetate and deoxycorticosterone acetate on salt appetite in mice. Physiol Behav. 1993 Oct;54(4):671-5.
[3] Jackson D, Connolly K, Batacan R, Ryan K, Vella R, Fenning A. (-)-Epicatechin Reduces Blood Pressure and Improves Left Ventricular Function and Compliance in Deoxycorticosterone Acetate-Salt Hypertensive Rats. Molecules. 2018 Jun 22;23(7):1511.
[4] Ito H, Majima M, Nakajima S, Hayashi I, Katori M, Izumi T. Effect of prolonged administration of a urinary kinase inhibitor, ebelactone B on the development of deoxycorticosterone acetate-salt hypertension in rats. Br J Pharmacol. 1999 Feb;126(3):613-20.
[5] Sonnenberg H. Proximal and distal tubular function in salt-deprived and in salt-loaded deoxycorticosterone acetate-escaped rats. J Clin Invest. 1973 Feb;52(2):263-72.
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Deoxycorticosterone Acetate 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.68mL
0.54mL
0.27mL
13.42mL
2.68mL
1.34mL
26.85mL
5.37mL
2.68mL
Deoxycorticosterone Acetate 技术信息
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