Yohimbine HCl is naturall occuring alpha-2 adrenergic antagonist derived from the bark of the African tree Pausinystalia johimbe, used as a veterinary drug to reverse sedation in dogs and deer.

Uric acid sodium是一种清除氧自由基的重要抗氧化剂，有助于维持血压的稳定和抗氧化应激，能够清除活性氧（ROS）（如单线态氧和过氧亚硝酸盐），并抑制脂质过氧化。

Angiotensin II human acetate（血管紧张素II）乙酸盐作为一种血管收缩剂，是肾素/血管紧张素系统的主要生物活性肽。它在调节人类血压中起核心作用，主要通过血管紧张素II与G蛋白偶联受体（GPCR）血管紧张素II 1型受体（AT1R）和血管紧张素II 2型受体（AT2R）之间的相互作用介导。人类血管紧张素II乙酸盐通过LOX-1依赖的氧化还原敏感途径刺激交感神经兴奋、增加醛固酮的生物合成和肾脏作用、诱导血管平滑肌细胞的生长、增加成纤维细胞中I型和III型胶原的合成，从而导致血管壁和心肌的增厚以及纤维化。它还通过LOX-1依赖的氧化还原敏感途径诱导内皮细胞的凋亡和毛细血管形成。

血管紧张素II是一种强效的血管收缩剂，会引起血压上升，并增加血管壁的机械负荷。长期的血压升高会进一步加剧动脉壁的应力，促进动脉瘤的形成。

Deoxycorticosterone acetate is a corticosteroid hormone which can induce hypertension dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.

Uric acid activates NFκB in a variety of cell culture models including proximal tubular cells. Uric acid suppresses 1-α hydroxylase mRNA and protein expression in dose dependent and time dependent manner.

L-NAME HCl is a non-selective NOS inhibitor with Ki values of 15 nM, 39 nM and 4.4 μM for nNOS (bovine), eNOS (human), and iNOS (murine), respectively.