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仙茅苷 /Curculigoside {[allProObj[0].p_purity_real_show]}

货号:A373670 同义名: Curculigoside A Ambeed 开学季,买赠积分,赢豪礼

Curculigoside, a natural product isolated and purified from the rhizomes of Curculigo orchioides Gaertn., can prevent bone loss, improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders.Curculigoside can also promote calcium deposition and increase the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character, and possesses potent antioxidant properties against oxidative stress insults.

Curculigoside 化学结构 CAS号:85643-19-2
Curculigoside 化学结构
CAS号:85643-19-2
Curculigoside 3D分子结构
CAS号:85643-19-2
Curculigoside 化学结构 CAS号:85643-19-2
Curculigoside 3D分子结构 CAS号:85643-19-2
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Curculigoside 纯度/质量文件 产品仅供科研

货号:A373670 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

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产品名称 JAK1 JAK2 JAK3 Tyk2 其他靶点 纯度
Decernotinib +++

JAK1, IC50: 11 nM

JAK1, Ki: 11 nM

+++

JAK2, Ki: 13 nM

++++

JAK3, Ki: 2.5 nM

+++

TYK2, Ki: 13 nM

{[allProObj[0].p_purity_real_show]}
ZM39923 HCl +

JAK1, pIC50: 4.4

+

JAK3, pIC50: 7.1

EGFR {[allProObj[0].p_purity_real_show]}
Cerdulatinib +++

JAK1, IC50: 12 nM

+++

JAK2, IC50: 6 nM

+++

JAK3, IC50: 8 nM

++++

TYK2, IC50: 0.5 nM

{[allProObj[0].p_purity_real_show]}
Momelotinib +++

JAK1, IC50: 11 nM

++

JAK2, IC50: 18 nM

+

JAK3, IC50: 155 nM

{[allProObj[0].p_purity_real_show]}
XL019 +

JAK1, IC50: 134.3 nM

++++

JAK2, IC50: 2.2 nM

+

JAK3, IC50: 214.2 nM

FLT3 {[allProObj[0].p_purity_real_show]}
Ruxolitinib +++

JAK1, IC50: 3.3 nM

++++

JAK2, IC50: 2.8 nM

{[allProObj[0].p_purity_real_show]}
Tofacitinib +

JAK1, IC50: 112 nM

++

JAK2, IC50: 20 nM

++++

JAK3, IC50: 1 nM

{[allProObj[0].p_purity_real_show]}
Ruxolitinib (S enantiomer) +++

JAK1, IC50: 3.3 nM

++++

JAK2, IC50: 2.8 nM

++

TYK2, IC50: 19 nM

{[allProObj[0].p_purity_real_show]}
Filgotinib +++

JAK1, IC50: 10 nM

++

JAK2, IC50: 28 nM

+

JAK3, IC50: 810 nM

+

TYK2, IC50: 116 nM

{[allProObj[0].p_purity_real_show]}
Baricitinib +++

JAK1, IC50: 5.9 nM

+++

JAK2, IC50: 5.7 nM

++

TYK2, IC50: 53 nM

{[allProObj[0].p_purity_real_show]}
Gandotinib ++

JAK1, IC50: 19.8 nM

++++

JAK2, IC50: 0.288 nM

JAK2 (V617F), Ki: 0.245 nM

++

JAK3, IC50: 48.0 nM

++

TYK2, IC50: 44 nM

FLT3 {[allProObj[0].p_purity_real_show]}
Oclacitinib maleate +++

JAK1, IC50: 10nM

++

JAK2, IC50: 18nM

+

JAK3, IC50: 99nM

+

TYK2, IC50: 84nM

{[allProObj[0].p_purity_real_show]}
NVP-BSK805 2HCl ++

JAK1, IC50: 31.63 nM

++++

JAK2, IC50: ~0.5 nM

++

JAK3, IC50: 18.68 nM

+++

TYK2, IC50: 10.76 nM

{[allProObj[0].p_purity_real_show]}
Peficitinib {[allProObj[0].p_purity_real_show]}
Go6976 FLT3 {[allProObj[0].p_purity_real_show]}
AZD-1480 ++++

JAK2, IC50: 0.26 nM

{[allProObj[0].p_purity_real_show]}
Fedratinib +++

JAK2 (V617F), IC50: 3 nM

JAK2, IC50: 3 nM

FLT3,RET {[allProObj[0].p_purity_real_show]}
WP1066 +

JAK2, IC50: 2.3 μM

{[allProObj[0].p_purity_real_show]}
Curcumol {[allProObj[0].p_purity_real_show]}
AZ960 ++++

JAK2, IC50: <3 nM

JAK2, Ki: 0.45 nM

{[allProObj[0].p_purity_real_show]}
GLPG0634 analog {[allProObj[0].p_purity_real_show]}
CEP-33779 ++++

JAK2, IC50: 1.8 nM

{[allProObj[0].p_purity_real_show]}
FLLL32 +

JAK2, IC50: <5 μM

{[allProObj[0].p_purity_real_show]}
WHI-P154 +

JAK3, IC50: 1.8 μM

VEGFR,Src,EGFR {[allProObj[0].p_purity_real_show]}
BMS-911543 ++++

JAK2, IC50: 1.1 nM

+

JAK3, IC50: 75 nM

++

TYK2, IC50: 66 nM

{[allProObj[0].p_purity_real_show]}
TG101209 +++

JAK2, IC50: 6 nM

+

JAK3, IC50: 169 nM

FLT3,RET {[allProObj[0].p_purity_real_show]}
AT9283 ++++

JAK2, IC50: 1.2 nM

++++

JAK3, IC50: 1.1 nM

{[allProObj[0].p_purity_real_show]}
Pacritinib ++

JAK2 (V617F), IC50: 19 nM

JAK2, IC50: 23 nM

+

JAK3, IC50: 520 nM

++

TYK2, IC50: 50 nM

FLT3 {[allProObj[0].p_purity_real_show]}
Tofacitinib citrate ++

JAK2, IC50: 20 nM

++++

JAK3, IC50: 1 nM

{[allProObj[0].p_purity_real_show]}
FM-381 ++++

JAK3, IC50: 127 pM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 NF-κB 其他靶点 纯度
Pyrrolidinedithiocarbamate ammonium {[allProObj[0].p_purity_real_show]}
QNZ ++++

NF-κB, IC50: 11 nM

{[allProObj[0].p_purity_real_show]}
Sodium 4-Aminosalicylate Dihydrate {[allProObj[0].p_purity_real_show]}
Sodium Salicylate {[allProObj[0].p_purity_real_show]}
Parthenolide p53 {[allProObj[0].p_purity_real_show]}
JSH-23 +

NF-κB, IC50: 7.1 μM

{[allProObj[0].p_purity_real_show]}
Phenethyl caffeate {[allProObj[0].p_purity_real_show]}
Andrographolide {[allProObj[0].p_purity_real_show]}
Curcumin HDAC,Nrf2 {[allProObj[0].p_purity_real_show]}
SC75741 +++

NF-κB, EC50: 200 nM

{[allProObj[0].p_purity_real_show]}
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

p53 {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 STAT1 STAT3 STAT5 其他靶点 纯度
Nifuroxazide {[allProObj[0].p_purity_real_show]}
Fludarabine {[allProObj[0].p_purity_real_show]}
Artesunate {[allProObj[0].p_purity_real_show]}
BP-1-102 +++

STAT3, Kd: 504 nM

{[allProObj[0].p_purity_real_show]}
Niclosamide ++

STAT3, IC50: 0.7 μM

{[allProObj[0].p_purity_real_show]}
Napabucasin {[allProObj[0].p_purity_real_show]}
Cryptotanshinone ++

STAT3, IC50: 4.6 μM

{[allProObj[0].p_purity_real_show]}
Stattic +

STAT3, IC50: 5.1 μM

{[allProObj[0].p_purity_real_show]}
NSC 74859 +

STAT3, IC50: 86 μM

{[allProObj[0].p_purity_real_show]}
Ochromycinone {[allProObj[0].p_purity_real_show]}
HO-3867 {[allProObj[0].p_purity_real_show]}
C188-9 ++++

STAT3, Kd: 4.7 nM

{[allProObj[0].p_purity_real_show]}
HJC0152 {[allProObj[0].p_purity_real_show]}
SH5-07 {[allProObj[0].p_purity_real_show]}
SH-4-54 ++++

STAT3, Kd: 300 nM

+++

STAT5, Kd: 464 nM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Curculigoside 生物活性

描述 Curculigoside, a natural product isolated and purified from the rhizomes of Curculigo orchioides Gaertn., can prevent bone loss, improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disorders.Curculigoside can also promote calcium deposition and increase the levels of ALP and Runx2 in osteoblasts under oxidative stress via anti-oxidative character, and possesses potent antioxidant properties against oxidative stress insults. can protect endothelial cells against oxidative injury induced by H2O2, suggesting that this compound may constitute a promising intervention against cardiovascular disorders.

Curculigoside 参考文献

[1]Liu M, Li Y, Yang ST. Curculigoside improves osteogenesis of human amniotic fluid-derived stem cells. Stem Cells Dev. 2014 Jan 15;23(2):146-54.

[2]Shen Q, Zeng D, et al. Curculigoside promotes osteogenic differentiation of bone marrow stromal cells from ovariectomized rats. J Pharm Pharmacol. 2013 Jul;65(7):1005-13.

Curculigoside 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.14mL

0.43mL

0.21mL

10.72mL

2.14mL

1.07mL

21.44mL

4.29mL

2.14mL

Curculigoside 技术信息

CAS号85643-19-2
分子式C17H18N4O4
分子量 466.44
别名 Curculigoside A
运输蓝冰
存储条件

粉末

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(225.11 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 2 mg/mL(4.29 mM)

动物实验配方
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