Stattic acts as a potent inhibitor of STAT3 and impedes STAT3 phosphorylation at Y705 and S727 [1]. Stattic hampers the binding of a high-affinity phosphopeptide for the SH2 domain of STAT3 [2]. Stattic improves renal function in Alport syndrome (AS) mice [3].
体内研究
Stattic (10 mg/kg, intraperitoneally, three times per week for 10 weeks) improves renal function in Alport syndrome (AS) mice [3].
体外研究
Stattic (20 μM; 24 hours) inhibits STAT3 phosphorylation at Y705 and selectively inhibits P-STAT3, as evidenced by the lack of inhibition of P-ERK1/2 in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines [1].
Stattic (2.5, 5, 10 μM; for 4 h) significantly decreases the nuclear levels of pSTAT3 and survivin at 10 μM. Stattic (2.5-10 μM; for 24 h) dose-dependently inhibits IL-6-induced STAT3 activation in PC3M-1E8 cells [2].
Stattic (2.5, 5, 10 μM; for 48 h) suppresses both the growth and induces apoptosis in prostate cancer cells (PC3M-1E8 cells) at 10 μM. However, no significant cell apoptosis is induced with 2.5 μM or 5 μM [2].
Stattic (2.5, 5, 10 μM; for 48 h) results in significant accumulation of cells in the S phase [2].
Stattic does not induce significant morphological changes or apoptosis and exhibits minimal STAT3 phosphorylation in A2780 cells and HUVECs [2].
Stattic 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
A431
2 μM
Growth Inhibition Assay
2 h
blocks EGF-reversed decreases in cell viability
25720435
A431
2 μM
Growth Inhibition Assay
2 h
increases in apoptosis induced by shikonin
25720435
C13*
0-10 μM
Apoptosis Assay
24/48 h
induces apoptosis in a dose and time dependent manner
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