GLPG0634 analog | GLPG0634 analogue | JAK Inhibitor | AmBeed-信号通路专用抑制剂

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GLPG0634类似物 /GLPG0634 analog {[allProObj[0].p_purity_real_show]}

货号：A467951 同义名： GLPG0634 analogue

GLPG0634 analog is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3.

GLPG0634 analog 化学结构
CAS号：1206101-20-3

GLPG0634 analog 3D分子结构
CAS号：1206101-20-3

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GLPG0634 analog 纯度/质量文件产品仅供科研

货号：A467951 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

JAK 亚型比较

产品名称	JAK1 ↓ ↑	JAK2 ↓ ↑	JAK3 ↓ ↑	Tyk2 ↓ ↑	其他靶点	纯度
Decernotinib	+++ JAK1, IC50: 11 nM JAK1, Ki: 11 nM	+++ JAK2, Ki: 13 nM	++++ JAK3, Ki: 2.5 nM	+++ TYK2, Ki: 13 nM		99%+
ZM39923 HCl	+ JAK1, pIC50: 4.4		+ JAK3, pIC50: 7.1		EGFR	97%
Cerdulatinib	+++ JAK1, IC50: 12 nM	+++ JAK2, IC50: 6 nM	+++ JAK3, IC50: 8 nM	++++ TYK2, IC50: 0.5 nM		99%+
Momelotinib	+++ JAK1, IC50: 11 nM	++ JAK2, IC50: 18 nM	+ JAK3, IC50: 155 nM			99%+
XL019	+ JAK1, IC50: 134.3 nM	++++ JAK2, IC50: 2.2 nM	+ JAK3, IC50: 214.2 nM		FLT3	99%+
Ruxolitinib	+++ JAK1, IC50: 3.3 nM	++++ JAK2, IC50: 2.8 nM				98%
Tofacitinib	+ JAK1, IC50: 112 nM	++ JAK2, IC50: 20 nM	++++ JAK3, IC50: 1 nM			98%
Ruxolitinib (S enantiomer)	+++ JAK1, IC50: 3.3 nM	++++ JAK2, IC50: 2.8 nM		++ TYK2, IC50: 19 nM		98%
Filgotinib	+++ JAK1, IC50: 10 nM	++ JAK2, IC50: 28 nM	+ JAK3, IC50: 810 nM	+ TYK2, IC50: 116 nM		99%
Baricitinib	+++ JAK1, IC50: 5.9 nM	+++ JAK2, IC50: 5.7 nM		++ TYK2, IC50: 53 nM		99%
Gandotinib	++ JAK1, IC50: 19.8 nM	++++ JAK2, IC50: 0.288 nM JAK2 (V617F), Ki: 0.245 nM	++ JAK3, IC50: 48.0 nM	++ TYK2, IC50: 44 nM	FLT3	99%+
Oclacitinib maleate	+++ JAK1, IC50: 10nM	++ JAK2, IC50: 18nM	+ JAK3, IC50: 99nM	+ TYK2, IC50: 84nM		98+%
NVP-BSK805 2HCl	++ JAK1, IC50: 31.63 nM	++++ JAK2, IC50: ~0.5 nM	++ JAK3, IC50: 18.68 nM	+++ TYK2, IC50: 10.76 nM		99+%
Peficitinib		✔				98%
Go6976		✔			FLT3	99%+
AZD-1480		++++ JAK2, IC50: 0.26 nM				99%+
Fedratinib		+++ JAK2, IC50: 3 nM JAK2 (V617F), IC50: 3 nM			FLT3,RET	99%+
WP1066		+ JAK2, IC50: 2.3 μM				98%
Curcumol		✔				98%
AZ960		++++ JAK2, IC50: <3 nM JAK2, Ki: 0.45 nM				97%
GLPG0634 analog		✔				99%+
CEP-33779		++++ JAK2, IC50: 1.8 nM				99%+
FLLL32		+ JAK2, IC50: <5 μM				99%+
WHI-P154			+ JAK3, IC50: 1.8 μM		EGFR,Src,VEGFR	98%
BMS-911543		++++ JAK2, IC50: 1.1 nM	+ JAK3, IC50: 75 nM	++ TYK2, IC50: 66 nM		98%
TG101209		+++ JAK2, IC50: 6 nM	+ JAK3, IC50: 169 nM		FLT3,RET	99%+
AT9283		++++ JAK2, IC50: 1.2 nM	++++ JAK3, IC50: 1.1 nM			99%+
Pacritinib		++ JAK2, IC50: 23 nM JAK2 (V617F), IC50: 19 nM	+ JAK3, IC50: 520 nM	++ TYK2, IC50: 50 nM	FLT3	97%
Tofacitinib citrate		++ JAK2, IC50: 20 nM	++++ JAK3, IC50: 1 nM			99%
FM-381			++++ JAK3, IC50: 127 pM			98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

GLPG0634 analog 生物活性

靶点	JAK2
描述	GLPG0634 analog is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3.

GLPG0634 analog 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02885181	Rheumatoid Arthritis	Phase 2	Completed	-	United States, Florida ... 展开 >> Omega Research Consultants DeBary, Florida, United States, 32713 Sarasota Arthritis Research Center Sarasota, Florida, United States, 34239 United States, Georgia Medical Associates of North Georgia Canton, Georgia, United States, 30114 United States, Kentucky Center For Arthritis and Osteoporosis Elizabethtown, Kentucky, United States, 42701 United States, New Mexico Albuquerque Center For Rheumatology Albuquerque, New Mexico, United States, 87102 United States, Pennsylvania Altoona Center for Clinical Research Duncansville, Pennsylvania, United States, 16635 United States, Texas Accurate Clinical Management - Najam Houston, Texas, United States, 77084 Accurate Clinical Research Inc. Stafford, Texas, United States, 77477 Medical Center Research LLC Webster, Texas, United States, 77598 Bulgaria MHAT-Plovdiv AD Plovdiv, Bulgaria, 4000 Umhat Kaspela Plovdiv, Bulgaria, 4003 NMTH Tsar Boris III Sofia, Bulgaria, 1233 Czechia A-Shine s.r.o. Plzen, Czechia, 31200 Medical Plus, S.R.O. Uherske Hradiste, Czechia, 68601 Georgia LLC Arensia Exploratory Medicine T'bilisi, Georgia, 0112 Moldova, Republic of ARENSIA Exploratory Medicine Phase I Unit, Republican Clinical Hospital Chisinau, Moldova, Republic of, MD-2025 Poland ClinicMed Badurski i wspolnicy Spolka Jawna Bialystok, Poland, 15-879 Ukraine Kharkiv City Hospital 8 Kharkiv, Ukraine, 140176 Medical Center_Clinic of International Institute of clinical Studies Kyiv, Ukraine, 2068 收起 <<
NCT02885181	-		Completed	-	-

GLPG0634 analog 参考文献

[1]Van Rompaey L, Galien R, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013 Oct 1;191(7):3568-77.

GLPG0634 analog 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.18mL

2.44mL

1.22mL

24.36mL

4.87mL

2.44mL

GLPG0634 analog 技术信息

CAS号	1206101-20-3
分子式	C₂₃H₁₈N₆O₂
分子量	410.428

别名	GLPG0634 analogue
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 50 mg/mL(121.82 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

GLPG0634类似物 /GLPG0634 analog {[allProObj[0].p_purity_real_show]}

GLPG0634 analog 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

GLPG0634 analog 质控信息

GLPG0634 analog 生物活性

GLPG0634 analog 临床研究

GLPG0634 analog 参考文献

GLPG0634 analog 实验方案

GLPG0634 analog 技术信息

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GLPG0634类似物 /GLPG0634 analog {[allProObj[0].p_purity_real_show]}

GLPG0634 analog 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

GLPG0634 analog 质控信息

GLPG0634 analog 生物活性

GLPG0634 analog 临床研究

GLPG0634 analog 参考文献

GLPG0634 analog 实验方案

GLPG0634 analog 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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GLPG0634 analog 纯度/质量文件产品仅供科研