BI-3231
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货号：A1942361
BI-3231 是一种选择性羟基类固醇 17β-脱氢酶 13 (HSD17B13) 抑制剂，对人类和小鼠 HSD17B13 的 IC50 分别为 1 和 13 nM，具有用于非酒精性脂肪性肝炎 (NASH) 和其他 肝脏疾病研究的潜力。
BI-3231 化学结构
BI-3231 3D分子结构
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会员价
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BI-3231 纯度/质量文件 产品仅供科研
货号：A1942361
标准纯度：
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产品说明书
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BI-3231 质控信息
Trilostane
✔
99+%
AGI-6780
+++
IDH2 R140Q mutant, IC50: 23 nM
99%+
Gimeracil
✔
98%
AGI-5198
++
R132H-IDH1, IC50: 70 nM
R132C-IDH1, IC50: 0.16 μM
99%+
SW033291
++++
15-PGDH, IC50: 1.5 nM
15-PGDH, Ki: 0.1 nM
99%+
Mycophenolic acid
✔
99+%
Fomepizole
✔
98%
Leflunomide
✔
98%
3-Nitropropanoic acid
✔
99%+
Isovaleramide
✔
98%
Mycophenolate Mofetil
+++
Inosine monophosphate dehydrogenase I, IC50: 39 nM
Inosine monophosphate dehydrogenase II, IC50: 27 nM
98%
MK-8245
++++
SCD1 (rat), IC50: 3 nM
SCD1 (mouse), IC50: 1 nM
99%+
Vidofludimus
++
Human DHODH, IC50: 134 nM
99%+
Emodin
✔
98%
Ivosidenib
✔
98%
NCT-501
++
98%
Gossypol
✔
99%+
Devimistat
✔
98%
Disulfiram
✔
98%+
Enasidenib
++++
98%
PluriSIn 1
✔
99%+
ML390
+
99%+
Teriflunomide
✔
99%+
Daidzin
+++
98+%
18β-Glycyrrhetinic acid
✔
99%
RRx-001
✔
95%
NCT-503
+
99%+
Vorasidenib
✔
99%+
Ammonium Glycyrrhizinate(x:1)
✔
98+%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
BI-3231 生物活性
描述
BI 3231 is a potent and selective inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. It shows promise for research in nonalcoholic steatohepatitis (NASH) and other liver diseases [1]
体内研究
BI 3231 exhibits rapid plasma clearance, yet maintains significant hepatic exposure for 48 hours [1]
体外研究
BI 3231 exhibits high metabolic stability in liver microsomes and moderate metabolic stability in hepatocytes [1]
BI-3231 参考文献
BI-3231 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.63mL
0.53mL
0.26mL
13.15mL
2.63mL
1.31mL
26.29mL
5.26mL
2.63mL
BI-3231 技术信息
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