产品说明书

BI-3231

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Chemical Structure| 2894848-07-6 同义名 : -
CAS号 : 2894848-07-6
货号 : A1942361
分子式 : C16H14F2N4O3S
纯度 : 98%
分子量 : 380.369
MDL号 : N/A
存储条件:

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(315.48 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 BI 3231 is a potent and selective inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. It shows promise for research in nonalcoholic steatohepatitis (NASH) and other liver diseases [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.15mL

2.63mL

1.31mL

26.29mL

5.26mL

2.63mL

参考文献

[1]Thamm S, et, al. Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science. J Med Chem. 2023 Feb 2.

[2]Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800. 2021-10-28.