橙皮油素 /Auraptene
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货号：A235149
同义名：
橙皮油内酯
/ 7-Geranyloxycoumarin
Auraptene 是从 Poncirus trifoliata 果皮中分离和纯化的天然产物，具有抗肿瘤和抗氧化活性。Auraptene 介导的 JNK 激活可能通过促进 γ-分泌酶活性来促进 Aβ 的产生。
Auraptene 化学结构
Auraptene 3D分子结构
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价格
会员价
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数量
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Auraptene 纯度/质量文件 产品仅供科研
货号：A235149
标准纯度：
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产品说明书
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Auraptene 质控信息
Mulberroside A
✔
99%+
Loureirin B
✔
Calcium Channel,Potassium Channel
99%+
Ginsenoside Re
✔
NF-κB
98%
(+)-(3R,8S)-Falcarindiol
✔
STAT,ERK
99%+
trans-Zeatin
✔
p38 MAPK,ERK
95+%
Urolithin B
✔
ERK,NF-κB
95%
Cucurbitacin IIb
✔
NF-κB
99%
Astragaloside IV
✔
Akt,mTOR,NF-κB
98%
NDMC101
✔
99%+
DB07268
++++
99%+
SP600125
+
+++
+++
+++
98%
JNK-IN-7
++++
++++
++++
99%
JNK-IN-8
++++
+++
++++
99%+
3,3',5-Triiodo-L-thyronine
++
++
+++
98%
IQ-1S free acid
+
++
+++
99%
BI-78D3
++
++
++
++
99%+
Bentamapimod
+++
+++
++
98%
Resveratrol
+
98%
Indirubin-3′-oxime
✔
99%+
SU3327
+
+
+
+
99%+
JNK Inhibitor VIII
++++
JNK1, Ki: 2 nM
JNK1, IC50: 45 nM
++++
JNK2, IC50: 160 nM
JNK2, Ki: 4 nM
+++
98%
Doramapimod
✔
99%+
RPI-1
✔
99%
TCS JNK 5a
++
++
98%
SP 600125, negative control
+
+
97%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Auraptene 生物活性
描述
Auraptene (AUR), is a natural prenyloxycoumarin found in plants belonging to Rutaceae and Apiaceae families. The IC50 values of Auraptene on KYSE30 cells after 24, 48, and 72 hours were 80,72,and76 μg/mL[3] [4]
Auraptene 参考文献
[1] Niu X, Huang Z, et al. Auraptene has the inhibitory property on murine T lymphocyte activation. Eur J Pharmacol. 2015 Mar 5;750:8-13.
[2] Yan H, Ma Z, et al. Anti-inflammatory effect of auraptene extracted from trifoliate orange (Poncirus trifoliate) on LPS-stimulated RAW 264.7 cells. Inflammation. 2013 Dec;36(6):1525-32.
[3] Saboor-Maleki S, Rassouli FB, Matin MM, Iranshahi M. Auraptene Attenuates Malignant Properties of Esophageal Stem-Like Cancer Cells. Technol Cancer Res Treat. 2017 Aug;16(4):519-527. doi: 10.1177/1533034616650119. Epub 2016 May 20. PMID: 27207438; PMCID: PMC5616061.
[4] Jang Y, Han J, Kim SJ, Kim J, Lee MJ, Jeong S, Ryu MJ, Seo KS, Choi SY, Shong M, Lim K, Heo JY, Kweon GR. Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation. Oncotarget. 2015 Nov 10;6(35):38127-38. doi: 10.18632/oncotarget.5511. PMID: 26474388; PMCID: PMC4741988.
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Auraptene 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.35mL
0.67mL
0.34mL
16.76mL
3.35mL
1.68mL
33.51mL
6.70mL
3.35mL
Auraptene 技术信息
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