Auraptene
产品说明书
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同义名 : | 橙皮油内酯 ;7-Geranyloxycoumarin |
| CAS号 : | 495-02-3 | |
| 货号 : | A235149 | |
| 分子式 : | C19H22O3 | |
| 纯度 : | 99% | |
| 分子量 : | 298.376 | |
| MDL号 : | MFCD00075948 | |
| 存储条件： |
Pure form Sealed in dry,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(167.57 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Auraptene (AUR), is a natural prenyloxycoumarin found in plants belonging to Rutaceae and Apiaceae families. The IC50 values of Auraptene on KYSE30 cells after 24, 48, and 72 hours were 80,72,and76 μg/mL[3]. Auraptene(100 μM) inhibits glycolytic and mitochondrial metabolism. Moreover, auraptene significantly reduces motility of RCC4 (Renal cell carcinoma ) cells and effectively inhibits tube formation by HUVECs cells under hypoxic condition[4]. Auraptene (100 μM ) induced the activation of ERK1/2 and auraptene (3 or 30 μM) promote neurite outgrowth from PC12 cells{Furukawa Y, Watanabe S, Okuyama S, Nakajima M. Neurotrophic effect of citrus auraptene: neuritogenic activity in PC12 cells. Int J Mol Sci. 2012;13(5):5338-5347. doi: 10.3390/ijms13055338. Epub 2012 Apr 27. PMID: 22754300; PMCID: PMC3382769.|https://pubmed.ncbi.nlm.nih.gov/22754300/}}. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.35mL 0.67mL 0.34mL |
16.76mL 3.35mL 1.68mL |
33.51mL 6.70mL 3.35mL |
| 参考文献 |
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