货号:A119193 同义名: 麦角甾苷;毛蕊花苷 / Kusaginin;TJC160
Acteoside, is a natural product isolated and purified from the herbs of Cistanche deserticola Y.C. Ma with known antioxidant activity. It is a protein kinase C inhibitor (IC50 =25 μM).
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产品名称 | PKC ↓ ↑ | PKCα ↓ ↑ | PKCβ ↓ ↑ | PKCγ ↓ ↑ | PKCδ ↓ ↑ | PKCε ↓ ↑ | PKCζ ↓ ↑ | PKCη ↓ ↑ | PKCθ ↓ ↑ | 其他靶点 | 纯度 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Daphnetin |
+
PKC, IC50: 25.01 μM |
PKA,EGFR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Dequalinium Chloride | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||||
Quercetin | ✔ | Src,Sirtuin | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Myricetrin | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Go 6983 |
+++
PKCα, IC50: 7 nM |
+++
PKCβ, IC50: 7 nM |
+++
PKCγ, IC50: 6 nM |
+++
PKCδ, IC50: 10 nM |
++
PKCζ, IC50: 60 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||
Go6976 |
+++
PKC, IC50: 7.9 nM |
++++
PKCα, IC50: 2.3 nM |
+++
PKCβ1, IC50: 6.2 nM |
FLT3 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
Bisindolylmaleimide I |
+++
PKCα, IC50: 20 nM |
+++
PKCβ1, IC50: 17 nM PKCβ2, IC50: 16 nM |
+++
PKCγ, IC50: 20 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Lawsone methyl ether | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Sotrastaurin |
++++
PKCα, Ki: 0.95 nM |
++++
PKCβ1, Ki: 0.64 nM |
++++
PKCδ, Ki: 2.1 nM |
++++
PKCε, Ki: 3.2 nM |
++++
PKCη, Ki: 1.8 nM |
++++
PKCθ, Ki: 0.22 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||
Enzastaurin |
++
PKCα, IC50: 39 nM |
+++
PKCβ, IC50: 6 nM |
+
PKCγ, IC50: 83 nM |
+
PKCε, IC50: 110 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
Midostaurin |
++
PKCα, IC50: 22 nM |
++
PKCβ1, IC50: 30 nM PKCβ2, IC50: 31 nM |
++
PKCγ, IC50: 24 nM |
+
PKCδ, IC50: 330 nM |
+
PKCε, IC50: 1.25 μM |
+
PKCη, IC50: 160 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||
Ro 31-8220 mesylate |
++++
PKCα, IC50: 5 nM |
+++
PKCβ1, IC50: 24 nM PKCβ2, IC50: 14 nM |
++
PKCγ, IC50: 27 nM |
++
PKCε, IC50: 24 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
Staurosporine |
++++
PKCα, IC50: 2 nM |
++++
PKCγ, IC50: 5 nM |
+++
PKCδ, IC50: 20 nM |
++
PKCε, IC50: 73 nM |
++++
PKCη, IC50: 4 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||
Ruboxistaurin HCl |
+
PKCα, IC50: 0.36 μM |
++++
PKCβ1, IC50: 4.7 nM PKCβ2, IC50: 5.9 nM |
+
PKCγ, IC50: 0.3 μM |
+
PKCδ, IC50: 0.25 μM |
++
PKCη, IC50: 0.052 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | ALK1 ↓ ↑ | ALK2 ↓ ↑ | ALK3 ↓ ↑ | ALK4 ↓ ↑ | ALK6 ↓ ↑ | Smad3 ↓ ↑ | TGF-β ↓ ↑ | TGFβRI/ALK5 ↓ ↑ | TGFβRII ↓ ↑ | 其他靶点 | 纯度 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LDN193189 |
++++
ALK1, IC50: 0.8 nM |
++++
ALK2, IC50: 0.8 nM |
+++
ALK3, IC50: 5.3 nM |
+++
ALK6, IC50: 16.7 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
LDN-212854 |
++++
ALK1, IC50: 2.4 nM |
++++
ALK2, IC50: 1.3 nM |
+
ALK3, IC50: 85.8 nM |
+
ALK4, IC50: 2133 nM |
+
ALK5, IC50: 9276 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||
ML347 |
++
ALK1, IC50: 46 nM |
++
ALK2, IC50: 32 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
K02288 |
++++
ALK1, IC50: 1.8 nM |
++++
ALK2, IC50: 1.1 nM |
++
ALK3, IC50: 34.4 nM |
+++
ALK6, IC50: 6.4 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
LDN-193189 dihydrochloride |
++++
ALK1, IC50: 0.8 nM |
++++
ALK2, IC50: 0.8 nM |
+++
ALK3, IC50: 5.3 nM |
+++
ALK6, IC50: 16.7 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
LDN-214117 |
++
ALK2, IC50: 24 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
DMH-1 |
+
ALK2, IC50: 107.9 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SB-505124 |
+
ALK4, IC50: 129 nM |
++
ALK5, IC50: 47 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Vactosertib |
+++
ALK4, IC50: 13 nM |
+++
ALK5, IC50: 11 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Alantolactone | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SIS3 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Pirfenidone | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Hesperetin | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
RepSox |
++++
TGFβR1(ALK5), IC50: 4 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
GW788388 |
+++
ALK5, IC50: 18 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
LY364947 |
++
TGFβRI, IC50: 59 nM |
+
TGFβRII, IC50: 0.4 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
SD-208 |
++
TGF-βRI (ALK5), IC50: 48 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SB-525334 |
+++
TGFβR1(ALK5), IC50: 14.3 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
LY2109761 |
++
TβRI, Ki: 38 nM |
+
TβRII, Ki: 300 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Galunisertib |
++
TβRI, IC50: 56 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SB 431542 |
+
ALK5, IC50: 94 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Acteoside (Verbascoside) is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity[3]. Acteoside inhibited cell proliferation, colony formation and migration in all the three human HCC cell lines BEL7404, HLF and JHH-7. The prohibition of angiogenesis by acteoside was revealed by the inhibition of tube formation and cell migration of HUVECs[4]. ACT (Acteoside) has the potential therapeutic effect on OA (Osteoarthritis) through inhibiting the inflammatory responses via inactivating JAK/STAT signaling pathway[5]. Acteoside can alleviate mesangial cell inflammatory injury by modulating Th22 lymphocytes chemotaxis and proliferation[6]. In addition, acteoside could penetrate BBB (blood-brain-barrier) and have potential therapeutic value for PD (Parkinson's disease) by activating the Nrf2/ARE signaling pathway and attenuating the oxidative stress[7]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT03641248 | Osteoarthritis, Knee | Early Phase 1 | Not yet recruiting | June 2019 | United States, Missouri ... 展开 >> Univ of Missouri Health Care Center Not yet recruiting Columbia, Missouri, United States, 65211 Contact: Dean Hainsworth, MD 573-882-4894 ClinicalResearch@health.missouri.edu 收起 << |
NCT02662283 | IGA Nephropathy | Phase 2 Phase 3 | Unknown | November 2016 | China, Guangdong ... 展开 >> Department of Nephrology, 6th Affiliated Hospital, Sun Yat-Sen University Guangzhou, Guangdong, China, 510655 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.60mL 0.32mL 0.16mL |
8.01mL 1.60mL 0.80mL |
16.01mL 3.20mL 1.60mL |
CAS号 | 61276-17-3 |
分子式 | C29H36O15 |
分子量 | 624.59 |
别名 | 麦角甾苷;毛蕊花苷;毛蕊花糖苷 ;Kusaginin;TJC160;Acetoside;NSC 603831;Verbascoside |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(168.11 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(160.11 mM) |
动物实验配方 |