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类叶升麻苷 /Acteoside {[allProObj[0].p_purity_real_show]}

货号：A119193 同义名： 麦角甾苷;毛蕊花苷 / Kusaginin;TJC160 Ambeed 开学季，买赠积分，赢豪礼

Acteoside, is a natural product isolated and purified from the herbs of Cistanche deserticola Y.C. Ma with known antioxidant activity. It is a protein kinase C inhibitor (IC50 =25 μM).

Acteoside 化学结构 CAS号：61276-17-3
Acteoside 化学结构
CAS号：61276-17-3
Acteoside 3D分子结构
CAS号：61276-17-3
Acteoside 化学结构 CAS号：61276-17-3
Acteoside 3D分子结构 CAS号：61276-17-3
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Acteoside 纯度/质量文件 产品仅供科研

货号：A119193 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 PKC ↓ PKCα ↓ PKCβ ↓ PKCγ ↓ PKCδ ↓ PKCε ↓ PKCζ ↓ PKCη ↓ PKCθ ↓ 其他靶点 纯度
Daphnetin +

PKC, IC50: 25.01 μM

 		PKA,EGFR {[allProObj[0].p_purity_real_show]}
Dequalinium Chloride {[allProObj[0].p_purity_real_show]}
Quercetin ✔ Src,Sirtuin {[allProObj[0].p_purity_real_show]}
Myricetrin ✔ {[allProObj[0].p_purity_real_show]}
Go 6983 +++

PKCα, IC50: 7 nM

 		+++

PKCβ, IC50: 7 nM

 		+++

PKCγ, IC50: 6 nM

 		+++

PKCδ, IC50: 10 nM

 		++

PKCζ, IC50: 60 nM

 		{[allProObj[0].p_purity_real_show]}
Go6976 +++

PKC, IC50: 7.9 nM

 		++++

PKCα, IC50: 2.3 nM

 		+++

PKCβ1, IC50: 6.2 nM

 		FLT3 {[allProObj[0].p_purity_real_show]}
Bisindolylmaleimide I +++

PKCα, IC50: 20 nM

 		+++

PKCβ1, IC50: 17 nM

PKCβ2, IC50: 16 nM

 		+++

PKCγ, IC50: 20 nM

 		{[allProObj[0].p_purity_real_show]}
Lawsone methyl ether ✔ {[allProObj[0].p_purity_real_show]}
Sotrastaurin ++++

PKCα, Ki: 0.95 nM

 		++++

PKCβ1, Ki: 0.64 nM

 		++++

PKCδ, Ki: 2.1 nM

 		++++

PKCε, Ki: 3.2 nM

 		++++

PKCη, Ki: 1.8 nM

 		++++

PKCθ, Ki: 0.22 nM

 		{[allProObj[0].p_purity_real_show]}
Enzastaurin ++

PKCα, IC50: 39 nM

 		+++

PKCβ, IC50: 6 nM

 		+

PKCγ, IC50: 83 nM

 		+

PKCε, IC50: 110 nM

 		{[allProObj[0].p_purity_real_show]}
Midostaurin ++

PKCα, IC50: 22 nM

 		++

PKCβ1, IC50: 30 nM

PKCβ2, IC50: 31 nM

 		++

PKCγ, IC50: 24 nM

 		+

PKCδ, IC50: 330 nM

 		+

PKCε, IC50: 1.25 μM

 		+

PKCη, IC50: 160 nM

 		{[allProObj[0].p_purity_real_show]}
Ro 31-8220 mesylate ++++

PKCα, IC50: 5 nM

 		+++

PKCβ1, IC50: 24 nM

PKCβ2, IC50: 14 nM

 		++

PKCγ, IC50: 27 nM

 		++

PKCε, IC50: 24 nM

 		{[allProObj[0].p_purity_real_show]}
Staurosporine ++++

PKCα, IC50: 2 nM

 		++++

PKCγ, IC50: 5 nM

 		+++

PKCδ, IC50: 20 nM

 		++

PKCε, IC50: 73 nM

 		++++

PKCη, IC50: 4 nM

 		{[allProObj[0].p_purity_real_show]}
Ruboxistaurin HCl +

PKCα, IC50: 0.36 μM

 		++++

PKCβ1, IC50: 4.7 nM

PKCβ2, IC50: 5.9 nM

 		+

PKCγ, IC50: 0.3 μM

 		+

PKCδ, IC50: 0.25 μM

 		++

PKCη, IC50: 0.052 μM

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 ALK1 ↓ ALK2 ↓ ALK3 ↓ ALK4 ↓ ALK6 ↓ Smad3 ↓ TGF-β ↓ TGFβRI/ALK5 ↓ TGFβRII ↓ 其他靶点 纯度
LDN193189 ++++

ALK1, IC50: 0.8 nM

 		++++

ALK2, IC50: 0.8 nM

 		+++

ALK3, IC50: 5.3 nM

 		+++

ALK6, IC50: 16.7 nM

 		{[allProObj[0].p_purity_real_show]}
LDN-212854 ++++

ALK1, IC50: 2.4 nM

 		++++

ALK2, IC50: 1.3 nM

 		+

ALK3, IC50: 85.8 nM

 		+

ALK4, IC50: 2133 nM

 		+

ALK5, IC50: 9276 nM

 		{[allProObj[0].p_purity_real_show]}
ML347 ++

ALK1, IC50: 46 nM

 		++

ALK2, IC50: 32 nM

 		{[allProObj[0].p_purity_real_show]}
K02288 ++++

ALK1, IC50: 1.8 nM

 		++++

ALK2, IC50: 1.1 nM

 		++

ALK3, IC50: 34.4 nM

 		+++

ALK6, IC50: 6.4 nM

 		{[allProObj[0].p_purity_real_show]}
LDN-193189 dihydrochloride ++++

ALK1, IC50: 0.8 nM

 		++++

ALK2, IC50: 0.8 nM

 		+++

ALK3, IC50: 5.3 nM

 		+++

ALK6, IC50: 16.7 nM

 		{[allProObj[0].p_purity_real_show]}
LDN-214117 ++

ALK2, IC50: 24 nM

 		{[allProObj[0].p_purity_real_show]}
DMH-1 +

ALK2, IC50: 107.9 nM

 		{[allProObj[0].p_purity_real_show]}
SB-505124 +

ALK4, IC50: 129 nM

 		++

ALK5, IC50: 47 nM

 		{[allProObj[0].p_purity_real_show]}
Vactosertib +++

ALK4, IC50: 13 nM

 		+++

ALK5, IC50: 11 nM

 		{[allProObj[0].p_purity_real_show]}
Alantolactone ✔ {[allProObj[0].p_purity_real_show]}
SIS3 ✔ {[allProObj[0].p_purity_real_show]}
Pirfenidone ✔ {[allProObj[0].p_purity_real_show]}
Hesperetin ✔ {[allProObj[0].p_purity_real_show]}
RepSox ++++

TGFβR1(ALK5), IC50: 4 nM

 		{[allProObj[0].p_purity_real_show]}
GW788388 +++

ALK5, IC50: 18 nM

 		{[allProObj[0].p_purity_real_show]}
LY364947 ++

TGFβRI, IC50: 59 nM

 		+

TGFβRII, IC50: 0.4 μM

 		{[allProObj[0].p_purity_real_show]}
SD-208 ++

TGF-βRI (ALK5), IC50: 48 nM

 		{[allProObj[0].p_purity_real_show]}
SB-525334 +++

TGFβR1(ALK5), IC50: 14.3 nM

 		{[allProObj[0].p_purity_real_show]}
LY2109761 ++

TβRI, Ki: 38 nM

 		+

TβRII, Ki: 300 nM

 		{[allProObj[0].p_purity_real_show]}
Galunisertib ++

TβRI, IC50: 56 nM

 		{[allProObj[0].p_purity_real_show]}
SB 431542 +

ALK5, IC50: 94 nM

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Acteoside 生物活性

描述 Acteoside (Verbascoside) is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity[3]. Acteoside inhibited cell proliferation, colony formation and migration in all the three human HCC cell lines BEL7404, HLF and JHH-7. The prohibition of angiogenesis by acteoside was revealed by the inhibition of tube formation and cell migration of HUVECs[4]. ACT (Acteoside) has the potential therapeutic effect on OA (Osteoarthritis) through inhibiting the inflammatory responses via inactivating JAK/STAT signaling pathway[5]. Acteoside can alleviate mesangial cell inflammatory injury by modulating Th22 lymphocytes chemotaxis and proliferation[6]. In addition, acteoside could penetrate BBB (blood-brain-barrier) and have potential therapeutic value for PD (Parkinson's disease) by activating the Nrf2/ARE signaling pathway and attenuating the oxidative stress[7].

Acteoside 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03641248 Osteoarthritis, Knee Early Phase 1 Not yet recruiting June 2019 United States, Missouri ... 展开 >> Univ of Missouri Health Care Center Not yet recruiting Columbia, Missouri, United States, 65211 Contact: Dean Hainsworth, MD    573-882-4894    ClinicalResearch@health.missouri.edu 收起 <<
NCT02662283 IGA Nephropathy Phase 2 Phase 3 Unknown November 2016 China, Guangdong ... 展开 >> Department of Nephrology, 6th Affiliated Hospital, Sun Yat-Sen University Guangzhou, Guangdong, China, 510655 收起 <<

Acteoside 参考文献

[1]Santoro A, Bianco G, et al. Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins. Toxicol Lett. 2008 May 5;178(2):71-6.

[2]Herbert JM, Maffrand JP, et al. Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. J Nat Prod. 1991 Nov-Dec;54(6):1595-600.

[3]Herbert JM, Maffrand JP, Taoubi K, Augereau JM, Fouraste I, Gleye J. Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. J Nat Prod. 1991 Nov-Dec;54(6):1595-600

[4]Ma D, Wang J, Liu L, Chen M, Wang Z. Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study. BMC Cancer. 2020 Sep 29;20(1):936

[5]Qiao Z, Tang J, Wu W, Tang J, Liu M. Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats. BMC Complement Altern Med. 2019 Oct 7;19(1):264

[6]Gan L, Li X, Zhu M, Chen C, Luo H, Zhou Q. Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy. Ren Fail. 2018 Nov;40(1):364-370

[7]Li M, Zhou F, Xu T, Song H, Lu B. Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway. Food Chem Toxicol. 2018 Sep;119:6-13

Acteoside 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.01mL

1.60mL

0.80mL

16.01mL

3.20mL

1.60mL

Acteoside 技术信息

CAS号61276-17-3
分子式C29H36O15
分子量 624.59
别名 麦角甾苷;毛蕊花苷;毛蕊花糖苷 ;Kusaginin;TJC160;Acetoside;NSC 603831;Verbascoside
运输蓝冰
存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(168.11 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(160.11 mM)
动物实验配方

Tags: Verbascoside | 61276-17-3 | Acteoside | Kusaginin | TJC160 | TJC160 | TJC 160 | TJC-160 | Bacterial Inhibitor | Epigenetics | TGF-beta/Smad | Apoptosis | Anti-infection | PKC | Apoptosis | Bacterial | HSV | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Acteoside 纯度/质量文件 | Acteoside 亚型比较 | Acteoside 生物活性 | Acteoside 临床数据 | Acteoside 参考文献 | Acteoside 实验方案 | Acteoside 技术信息

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