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Acteoside

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Chemical Structure| 61276-17-3 同义名 : 麦角甾苷;毛蕊花苷;毛蕊花糖苷 ;Kusaginin;TJC160;Acetoside;NSC 603831;Verbascoside
CAS号 : 61276-17-3
货号 : A119193
分子式 : C29H36O15
纯度 : 99%+
分子量 : 624.59
MDL号 : MFCD00221751
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(168.11 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(160.11 mM)
动物实验配方：
生物活性
描述 Acteoside (Verbascoside) is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity[3]. Acteoside inhibited cell proliferation, colony formation and migration in all the three human HCC cell lines BEL7404, HLF and JHH-7. The prohibition of angiogenesis by acteoside was revealed by the inhibition of tube formation and cell migration of HUVECs[4]. ACT (Acteoside) has the potential therapeutic effect on OA (Osteoarthritis) through inhibiting the inflammatory responses via inactivating JAK/STAT signaling pathway[5]. Acteoside can alleviate mesangial cell inflammatory injury by modulating Th22 lymphocytes chemotaxis and proliferation[6]. In addition, acteoside could penetrate BBB (blood-brain-barrier) and have potential therapeutic value for PD (Parkinson's disease) by activating the Nrf2/ARE signaling pathway and attenuating the oxidative stress[7].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03641248 Osteoarthritis, Knee Early Phase 1 Not yet recruiting June 2019 United States, Missouri ... 展开 >> Univ of Missouri Health Care Center Not yet recruiting Columbia, Missouri, United States, 65211 Contact: Dean Hainsworth, MD    573-882-4894    ClinicalResearch@health.missouri.edu 收起 <<
NCT02662283 IGA Nephropathy Phase 2 Phase 3 Unknown November 2016 China, Guangdong ... 展开 >> Department of Nephrology, 6th Affiliated Hospital, Sun Yat-Sen University Guangzhou, Guangdong, China, 510655 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.01mL

1.60mL

0.80mL

16.01mL

3.20mL

1.60mL
参考文献

[1]Santoro A, Bianco G, et al. Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins. Toxicol Lett. 2008 May 5;178(2):71-6.

[2]Herbert JM, Maffrand JP, et al. Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. J Nat Prod. 1991 Nov-Dec;54(6):1595-600.

[3]Herbert JM, Maffrand JP, Taoubi K, Augereau JM, Fouraste I, Gleye J. Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C. J Nat Prod. 1991 Nov-Dec;54(6):1595-600

[4]Ma D, Wang J, Liu L, Chen M, Wang Z. Acteoside as a potential therapeutic option for primary hepatocellular carcinoma: a preclinical study. BMC Cancer. 2020 Sep 29;20(1):936

[5]Qiao Z, Tang J, Wu W, Tang J, Liu M. Acteoside inhibits inflammatory response via JAK/STAT signaling pathway in osteoarthritic rats. BMC Complement Altern Med. 2019 Oct 7;19(1):264

[6]Gan L, Li X, Zhu M, Chen C, Luo H, Zhou Q. Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy. Ren Fail. 2018 Nov;40(1):364-370

[7]Li M, Zhou F, Xu T, Song H, Lu B. Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway. Food Chem Toxicol. 2018 Sep;119:6-13