ML347 is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM and shows > 300-fold selectivity for ALK2 vs. ALK3.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
The transforming growth factor (TGF)-β superfamily has been implicated into different physiological and pathological processes in a broad range of cell systems. The TGF-β receptor complex is composed of type I, type II and accessory receptors. TGF-β type I receptors have seven isoforms termed activin receptor-like kinases (ALKs) 1 - 7[2]. ML347 is a selective inhibitor of ALK1/2/3/6 with IC50 values of 46 nM, 32 nM, 10.8 μM and 9.83 μM, respectively[1]. In vitro, ML347 at dose of 50 nM dampened the GDF2-induced SMAD1/5 phosphorylation in MCF10A cells that express high levels of ALK2[3]. Utilizing rapid equilibrium dialysis, the protein binding of ML347 was determined in human, rat and mouse plasma shown that similar in all three species with ML347 displaying high plasma protein biding (Fu~0.01 - 0.015). ML347 was unstable to oxidative metabolism – possibly due to the labile methoxy group and therefore was predicted to display high clearance in human and mouse, and moderate to-high clearance in the rat[1].
搜索
HazMat Fee +
