土木香内酯 /Alantolactone
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货号：A354359
同义名：
土木香脑
/ Alant camphor;Inula camphor
Alantolactone 是一种倍半萜内酯，具有潜在的抗三阴性乳腺癌MDA-MB-231细胞的活性，通过抑制信号转导与转录激活因子3（STAT3）信号通路发挥作用。
Alantolactone 化学结构
Alantolactone 3D分子结构
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Alantolactone 纯度/质量文件 产品仅供科研
货号：A354359
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Alantolactone 质控信息
Alantolactone 生物活性
靶点
描述
Alantolactone is a sesquiterpene lactone extracted from Inula Helenium L with anti-inflammatory, antibacterial and anticancer activities. The half maximal inhibitory effect of alantolactone on cell proliferation concentration (IC50) was 35.45 μΜ at 24 h and 24.29 μΜ at 48 h. In addition, alantolactone at 10, 20 and 30 μΜ significantly downregulated the expression levels of MMP-2, MMP-7 and MMP-9 (matrix metalloproteinase ) protein[3] [5]
Alantolactone 参考文献
[1] Chun J, Li RJ, et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357(1):393-403.
[2] Khan M, Yi F, et al. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life. 2012 Sep;64(9):783-94.
[3] Liu J, Liu M, Wang S, He Y, Huo Y, Yang Z, Cao X. Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways. Int J Mol Med. 2018 Oct;42(4):1847-1856. doi: 10.3892/ijmm.2018.3751. Epub 2018 Jul 4. PMID: 30015828; PMCID: PMC6108867.
[4] Kim M, Song K, Kim YS. Alantolactone Improves Prolonged Exposure of Interleukin-6-Induced Skeletal Muscle Inflammation Associated Glucose Intolerance and Insulin Resistance. Front Pharmacol. 2017;8:405. Published 2017 Jun 29.
[5] Khan M, Li T, Ahmad Khan MK, Rasul A, Nawaz F, Sun M, Zheng Y, Ma T. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int. 2013;2013:719858. doi: 10.1155/2013/719858. Epub 2012 Dec 27. PMID: 23533997; PMCID: PMC3591150.
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Alantolactone 实验方案
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总药量计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
4.30mL
0.86mL
0.43mL
21.52mL
4.30mL
2.15mL
43.04mL
8.61mL
4.30mL
Alantolactone 技术信息
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