Exherin is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities and selectively and competitively binds to and blocks N-cadherin.
ADH-1 (0.2 mg/mL) inhibits collagen I-induced alterations in pancreatic cancer cells and significantly suppresses cell motility induced by N-cadherin expression. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner [1].
体内研究
ADH-1 (50 mg/kg) markedly inhibits tumor growth and metastasis in a murine model of pancreatic cancer. Additionally, ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model of pancreatic cancer using N-cadherin-overexpressing BxPC-3 cells [1].
ADH-1, at the doses tested, does not exhibit antiangiogenic activity in a rat aortic ring assay or demonstrate antitumor efficacy in a PC3 subcutaneous xenograft tumor model [2].
In A375 xenografts, but not in DM443 xenografts, ADH-1 treatment leads to an increase in phosphorylation of AKT at serine 473. Additionally, ADH-1 slightly reduces N-cadherin expression in both xenografts [3].
体外研究
ADH-1 (0.2 mg/mL) inhibits collagen I-induced alterations in pancreatic cancer cells and significantly suppresses cell motility induced by N-cadherin expression. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner [1].
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