There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of Efavirenz. It induces apoptosis in primary human hepatocytes via a JNK- and BimEL-dependent mechanism. This compound is utilized in cancer research [1]. 8-Hydroxyefavirenz as a click chemistry reagent, contains an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
体外研究
8-Hydroxyefavirenz (8-OH-EFV; 1-10 μM; 3-24 h) in primary human hepatocytes, prompts cell death in a time- and concentration-dependent manner, initiating caspase-3 activity at 6 hours [1].
8-Hydroxyefavirenz (1-10 μM; 6-24 h) triggers mitochondrial ROS production in primary human hepatocytes [1].
8-Hydroxyefavirenz at a concentration of 10 μM for 3-24 hours, activates JNK, increasing the ratio of phosphorylated JNK to total JNK by 4.2-fold. It also upregulates the mRNA and protein expression of BimEL [1].
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