8-Hydroxyefavirenz

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Chemical Structure| 205754-33-2 同义名 : 8-OH-EFV
CAS号 : 205754-33-2
货号 : A1340267
分子式 : C14H9ClF3NO3
纯度 : 98%+
分子量 : 331.674
MDL号 : N/A
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of Efavirenz. It induces apoptosis in primary human hepatocytes via a JNK- and BimEL-dependent mechanism. This compound is utilized in cancer research [1]. 8-Hydroxyefavirenz as a click chemistry reagent, contains an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.02mL

0.60mL

0.30mL

15.08mL

3.02mL

1.51mL

30.15mL

6.03mL

3.02mL
参考文献

[1]Bumpus NN. Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):227-34.