(-)-Pinoresinol | Anti-inflammatory Agent | AmBeed-信号通路专用抑制剂

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(-)-Pinoresinol {[allProObj[0].p_purity_real_show]}

货号：A198061

(-)-Pinoresinol, a natural product isolated and purified from the bark of Eucommia ulmoides.

(-)-Pinoresinol 化学结构
CAS号：81446-29-9

(-)-Pinoresinol 3D分子结构
CAS号：81446-29-9

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(-)-Pinoresinol 纯度/质量文件产品仅供科研

货号：A198061 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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MAO 亚型比较

产品名称	MAO ↓ ↑	MAO-A ↓ ↑	MAO-B ↓ ↑	纯度
Sennoside A	++ MAO, IC50: 17 μM			98%+
Glycyrrhizic acid	++++ MAO, IC50: 0.16 μM			80% HPLC
Rasagiline		++++ MAO-A, IC50: 412 nM	++++ MAO-B, IC50: 4.43 nM	99+%
Isatin	++ MAO, IC50: 15 μM	+ MAO-A, IC50: 58 μM	++ MAO-B, IC50: 14 μM	98%
Paeonol		+ MAO-A, IC50: 54.6 μM	+ MAO-B, IC50: 42.5 μM	98%
Tranylcypromine hydrochloride		+++ MAO-A, IC50: 11.5 μM	+++ MAO-B, IC50: 7 μM	97%
Moclobemide		+++ MAO-A (5-HT), IC50: 6.1 μM		99%+
Pargyline HCl		++ MAO-A, Ki: 13 μM	+++ MAO-B, Ki: 0.5 μM	99%+
Safinamide			++++ MAO-B, IC50: 98 nM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(-)-Pinoresinol 生物活性

描述

(-)-Pinoresinol, a natural product isolated and purified from the bark of Eucommia ulmoides, can ameliorate CCl4-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappaB and AP-1. (-)-Pinoresinol also possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans. (-)-Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, which can cause an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, suggests that this could be a mechanism by which PIN reduces proliferation and induces differentiation on HL60 cells.

(-)-Pinoresinol 参考文献

[1]Kim HY, Kim JK, et al. Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice. J Pharmacol Sci. 2010;112(1):105-12.

[2]Hwang B, Lee J, et al. Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii. Molecules. 2010 May 14;15(5):3507-16.

(-)-Pinoresinol 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.95mL

2.79mL

1.40mL

27.90mL

5.58mL

2.79mL

(-)-Pinoresinol 技术信息

CAS号	81446-29-9
分子式	C₂₀H₂₂O₆
分子量	358.385

别名
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末

溶解度

动物实验配方

(-)-Pinoresinol {[allProObj[0].p_purity_real_show]}

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(-)-Pinoresinol 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

(-)-Pinoresinol 质控信息

(-)-Pinoresinol 生物活性

(-)-Pinoresinol 参考文献

(-)-Pinoresinol 实验方案

(-)-Pinoresinol 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

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(-)-Pinoresinol 纯度/质量文件产品仅供科研