Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.

Flumequine is a topoisomerase II inhibitor with IC50 of 15 μM. It is a synthetic chemotherapeutic antibiotic.

Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM).

Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity.

Moxifloxacin is a fourth-generation fluoroquinolone antibiotic with expanded activity against gram-positive bacteria as well as atypical pathogens.

Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.

Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.

Dexrazoxane is both an antimitotic agent with immunosuppressive properties and a cardioprotective agent.

Genistein has multiple biological functions. It can inhibit several tyrosine kinases (IC50 of 0.6 μM for EGFR), inhibits DNA topoisomerase-II and activation of PPARs. Genistein is a phytoestrogen which has selective estrogen receptor modulator properties.

Levofloxacin is an inhibitor of type II topoisomerases. It can inhibit DNA gyrase and topoisomerase IV with IC50 of 8.06 µg/ml and 9.81 µg/ml. It is an antibacterial agent.

Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.

Marbofloxacin can inhibit DNA-gyrase and it is an antibiotic.

Novobiocin sodium is an antibiotic that derived from Streptomyces niveus.

Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.

Ofloxacin, a fluoroquinolone compound, can inhibit bacterial DNA gyrase.

Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent.

Levofloxacin Hemihydrate is antibiotic against gram-negative organisms, working by inhibiting the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.

Doxorubicin is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.

Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse.