EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits > 200-fold selectivity against SIRT2 and SIRT3.

Sirtinol是一种sirtuin（SIRT）抑制剂，对ySir2、hSIRT2和hSIRT2的IC50值分别为48 μM、57.7 μM和131 μM。

Suramin sodium salt (Suramin hexasodium salt) 是一种可逆的、竞争性的蛋白酪氨酸磷酸酶（PTPases）抑制剂。它是一种有效的sirtuins抑制剂：SirT1（IC50=297 nM）、SirT2（IC50=1.15 μM）和SirT5（IC50=22 μM），并且还作为一种逆转录酶的竞争性抑制剂（DNA拓扑异构酶II：IC50=5 μM）。苏拉明钠盐是一种有效的SARS-CoV-2 RNA依赖的RNA聚合酶（RdRp）抑制剂，并有效抑制IP5K。此外，它具有抗寄生虫、抗肿瘤和抗血管生成特性。

OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.

3-TYP是SIRT3的抑制剂 (IC50: ~377 Μm)，也抑制蛋氨酸腺苷化转移酶 (MAT)2和色氨酸2,3-二氧化酶 (IDO)。

Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator.

Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.

Inauhzin is a small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, and promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress (IC50=3 μM, in A549 cell).

Salermide, a reverse amide, can act as an inhibitor of sirt, especially of sirt2, with the property of inducing apoptosis of tumor cells.

Quercetin Dihydrate是一种天然黄酮类化合物，可刺激重组SIRT1并抑制PI3K，其对PI3K γ、PI3K δ和PI3K β的IC50值分别为2.4 μM、3.0 μM和5.4 μM。