Sirtinol是一种sirtuin（SIRT）抑制剂，对ySir2、hSIRT2和hSIRT2的IC50值分别为48 μM、57.7 μM和131 μM。

OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.

3-TYP是SIRT3的抑制剂 (IC50: ~377 Μm)，也抑制蛋氨酸腺苷化转移酶 (MAT)2和色氨酸2,3-二氧化酶 (IDO)。

Thiomyristoyl is an inhibitor of Sirt2 and Sirt1 with IC50 of 28 nM, 98 μM.

SirReal2是一种有效的、同型选择性的Sirt2抑制剂，其IC50值为140 nM，并对Sirt3-5具有最低的活性。SirReal2导致HeLa细胞中微管蛋白的高乙酰化和检查点蛋白BubR1的失稳。

AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.

Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator.

Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.