Zelasudil是一种针对Rho相关蛋白激酶（ROCK）的有效抑制剂，具有ROCK2结合的高度亲和力，显示出在相关疾病研究中的应用潜力。

ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively.

K-115 HCl is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.

RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, and has anti-invasive and antitumor activities.

ROCK inhibitor-2是一种选择性 ROCK1 和 ROCK2 双重抑制剂，IC₅₀ 分别为 17 nM 和 2 nM。该化合物可用于细胞骨架重塑、肿瘤转移及心血管疾病等研究领域，特别在细胞迁移和增殖的调控中具有应用潜力。

ROCK1-IN-1是一种 ROCK1 抑制剂，用于高血压、青光眼和勃起功能障碍等相关研究。

CAY10746是一种选择性 Rho 激酶 (ROCK) 抑制剂，对 ROCK I 和 ROCK II 的 IC₅₀ 分别为 0.014 μM 和 0.003 μM，广泛应用于糖尿病视网膜病变（DR）等与 ROCK 信号通路相关的疾病研究。

ROCK-IN-5是一种有效的 ROCK、ERK、GSK 和 AGC 蛋白激酶的抑制剂，具有在增殖性、心脏和神经退行性疾病研究中的潜力。

Belumosudil (KD025) 是一种选择性 ROCK2 抑制剂，对 ROCK2 的 IC50 值为 105 nM，对 ROCK1 的 IC50 值为 24 µM，具有抗纤维化特性。

GSK269962 HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

H-1152 2HCl, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.

Y-27632 是一种口服有效的、ATP 竞争性的 ROCK-I 和 ROCK-II 抑制剂，Ki 值分别为 220 nM 和 300 nM。

Y-33075 2HCl具有选择性作为 ROCK 抑制剂，IC50 为 3.6 nM。

Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

Netarsudil Mesylate是一种 ROCK 激酶和去甲肾上腺素转运体的双重抑制剂，适用于眼科疾病的研究，尤其是在降低眼内压及治疗青光眼方面具有显著的作用。

Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator.

SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays, and its IC50 for ROCK-I is 56 ± 12 nM.

Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes.

RKI-1447 2HCl是一种有效的选择性 ROCK 抑制剂，对 ROCK1 和 ROCK2 的 IC50 分别为 14.5 和 6.2 nM。它能抑制结直肠癌细胞的生长并促进细胞凋亡。