CAY10746 is a selective Rho kinase (ROCK) inhibitor, displaying inhibitory activity towards ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively, and is researched for its potential in treating diabetic retinopathy (DR) [1].
体外研究
CAY10746 inhibits ROCK I and ROCK II, with IC50 values of 0.014 μM and 0.003 μM, respectively [1].
CAY10746, at concentrations of 0.1, 1, and 10 μM and durations of 0.25, 1, 2, and 4 hours, inhibits ROCK kinase activity in SH-SY5Y cells [1].
CAY10746 at 1 μM inhibits endothelial cell migration in vitro over periods of 24 and 36 hours [1].
CAY10746 (1 μM; 5 days) shields retinal neurons from oxidative stress and apoptosis induced by high glucose [1].
CAY10746 (1 μM; 5 days) inhibits the excessive proliferation of Müller cells and promotes the regression of vascular vessels in retinal explants exposed to a high glucose microenvironment [1].
搜索
