Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
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Narciclasine triggers activation of Rho and stress fibers within glioblastoma multiforme (GBM) cells, exhibiting a mean IC50 of approximately 50 nM across six human GBM cell lines (U373, Hs683, GL19, GL5, GL16, GL17), which also demonstrates a mean IC50 value of 47 nM against a diverse array of 60 cancer cell lines[1]. Further exploration through bioassay-guided fractionation of A. belladonna extract pinpointed lycorine as the active compound, with Narciclasine showing a significant IC50 of 0.1 μM for radicle growth inhibition[2].
体内研究
In vivo studies reveal that an intravenous (i.v.) administration of Narciclasine at 1 mg/kg significantly enhances the survival rates of mice bearing GL19 GBM (P=0.02). Similarly, oral administration of Narciclasine at the same dosage, five times weekly for five weeks, markedly prolongs survival in this model (P=0.008). Oral treatment at 1 mg/kg also significantly boosts survival (P=0.004) in mice with Hs683 GBM, with no added survival benefit from increasing the dosage frequency. Narciclasine showcases efficacy comparable to that of temozolomide in these models, but at significantly lower doses and through both oral and i.v. routes[1].
体外研究
Narciclasine triggers activation of Rho and stress fibers within glioblastoma multiforme (GBM) cells, exhibiting a mean IC50 of approximately 50 nM across six human GBM cell lines (U373, Hs683, GL19, GL5, GL16, GL17), which also demonstrates a mean IC50 value of 47 nM against a diverse array of 60 cancer cell lines[1].
Further exploration through bioassay-guided fractionation of A. belladonna extract pinpointed lycorine as the active compound, with Narciclasine showing a significant IC50 of 0.1 μM for radicle growth inhibition[2].
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