Y-39983盐酸 /Y-33075 2HCl
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货号：A204681
同义名：
Y-39983 Dihydrochloride;Y-33075 Dihydrochloride
Y-33075 2HCl具有选择性作为 ROCK 抑制剂，IC50 为 3.6 nM。
Y-33075 2HCl 化学结构
Y-33075 2HCl 3D分子结构
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Y-33075 2HCl 纯度/质量文件 产品仅供科研
货号：A204681
标准纯度：
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Y-33075 2HCl 质控信息
Y-33075 2HCl 生物活性
靶点
描述
Rho-associated kinases (ROCK1 and ROCK2) are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoBm and RhoC. ROCKs are involved in diverse cellular activities and irregular ROCK activities could lead to cardiovascular diseases[3] [4] [5] [6]
Y-33075 2HCl 参考文献
[1] Feng Y, LoGrasso PV, et al. Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. J Med Chem. 2016 Mar 24;59(6):2269-300.
[2] Gao C, Huang L, et al. Y-39983, a selective Rho-kinase inhibitor, attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Neuroimmunomodulation. 2013;20(6):334-40.
[3] Hartmann, S. et al. The function of Rho-Associated Kinases ROCK1 and Rock2 in the Pathogenesis of Cardiovascular Diseases. Frontiers. 2015.
[4] Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 48(7), 3216-3222.
[5] Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. Epub. 2011. 55(4), 411-7.
[6] Gao, C., Huang, L., Long, Y., et al. Y-39983, a selective Rho-kinase inhibitor, attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Neuroimmunomodulation. 2013. 20(6), 334-340.
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Y-33075 2HCl 实验方案
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摩尔计算器
总药量计算器
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.83mL
0.57mL
0.28mL
14.15mL
2.83mL
1.42mL
28.31mL
5.66mL
2.83mL
Y-33075 2HCl 技术信息
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