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/ 肾上腺素能受体 / Terazosin hydrochloride dihydrate

盐酸特拉唑嗪(二水合物) /Terazosin hydrochloride dihydrate {[allProObj[0].p_purity_real_show]}

货号：A281463 同义名： 盐酸特拉唑嗪 二水合物 / Terazosin HCl Dihydrate

Terazosin HCl is an α-adrenergic (AL-fa ad-ren-ER-jik) blocker used in the therapy of hypertension and benign prostatic hypertrophy with climination half-life‎ of ‎12 hours.

Terazosin hydrochloride dihydrate 化学结构 CAS号：70024-40-7
Terazosin hydrochloride dihydrate 化学结构
CAS号：70024-40-7
Terazosin hydrochloride dihydrate 3D分子结构
CAS号：70024-40-7
Terazosin hydrochloride dihydrate 化学结构 CAS号：70024-40-7
Terazosin hydrochloride dihydrate 3D分子结构 CAS号：70024-40-7
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Terazosin hydrochloride dihydrate 纯度/质量文件 产品仅供科研

货号：A281463 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Adrenergic Receptor ↓ α-adrenergic receptor ↓ β-adrenergic receptor ↓ 其他靶点 纯度
Ivabradine HCl ✔ 98%
Maprotiline hydrochloride ✔ 98%
Cisatracurium besylate ✔ 98%
Yohimbine HCI ✔ 99+%
BMY 7378 ++

α2C-adrenoceptor, pKi: 6.54

α1D-adrenoceptor, pKi: 5.1

 		+

β1-adrenoceptor, pIC50: 5.1

 		97%
Asenapine maleate ++++

α2B-adrenergic receptor, pKi: 8.9

α2A-adrenergic receptor, pKi: 8.9

 		97%
Piribedil ++

adrenoceptor α2A, pKi: 7.1

adrenoceptor α2C, pKi: 7.2

 		98%
Prazosin HCl ✔ 95%
Silodosin ✔ 98%
Phenoxybenzamine HCl ✔ 98%
Naftopidil +++

α1D-adrenergic receptor, Ki: 20 nM

α1A-adrenergic receptor, Ki: 3.7 nM

 		98%
Naftopidil 2HCl +

α1-adrenergic receptor, IC50: 0.2 μM

 		97%
Alfuzosin HCl ✔ 98%
Terazosin HCl ✔ 99%
Atipamezole ✔ 95%
Phentolamine methanesulfonate salt ✔ 99%
Doxazosin mesylate ✔ 98%
Tolazoline HCl ✔ 98%
Zenidolol hydrochloride ++++

β1-adrenergic receptor, Ki: 611nM

β2-adrenergic receptor, Ki: 0.7nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Terazosin hydrochloride dihydrate 生物活性

描述 Terazosin Hydrochloride Dihydrate is a α1-adrenoceptor blocker with a long lasting actionused for the improvement of urinary obstruction due to benign prostatic hyperplasia (BPH)[3].Terazosin therapy results in a significant reduction in blood pressure in patients with mild to moderate essential hypertension, with little influence on heart rate[4]. Terazosin alleviated organ damage and improved survival in rodent models of stroke and sepsis[5].

Terazosin hydrochloride dihydrate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00000620 Atherosclerosis ... 展开 >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease 收起 << Phase 3 Completed - United States, Minnesota ... 展开 >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada 收起 <<
NCT01323998 - Completed - -
NCT03339258 Stress Disorders, Post-Traumat... 展开 >>ic 收起 << Phase 2 Recruiting June 2021 United States, California ... 展开 >> San Francisco VA Medical Center Recruiting San Francisco, California, United States, 94121 Contact: Andrew Levihn-Coon, B.A.    415-221-4810 ext 23809    andrew.levihn-coon@va.gov 收起 <<

Terazosin hydrochloride dihydrate 参考文献

[1]Nirmalani-Gandhy A, Sanchez D, Catalano G. Terazosin for the treatment of trauma-related nightmares: a report of 4 cases. Clin Neuropharmacol. 2015 May-Jun;38(3):109-11.

[2]Kyprianou N, Benning CM. Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer Res. 2000 Aug 15;60(16):4550-5.

[3]Attia AK, Mohamed Abdel-Moety M. Thermoanalytical investigation of terazosin hydrochloride. Adv Pharm Bull. 2013;3(1):147-52. doi: 10.5681/apb.2013.025. Epub 2013 Feb 7.

[4]Titmarsh S, Monk JP. Terazosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in essential hypertension. Drugs. 1987 May;33(5):461-77.

[5]Chen X, Zhao C, Li X, Wang T, Li Y, Cao C, Ding Y, Dong M, Finci L, Wang JH, Li X, Liu L. Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat Chem Biol. 2015 Jan;11(1):19-25.

Terazosin hydrochloride dihydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.87mL

2.17mL

1.09mL

21.74mL

4.35mL

2.17mL

Terazosin hydrochloride dihydrate 技术信息

CAS号70024-40-7
分子式C19H30ClN5O6
分子量 459.924
别名 盐酸特拉唑嗪 二水合物 ;Terazosin HCl Dihydrate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 30 mg/mL(65.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 12 mg/mL(26.09 mM)，配合低频超声助溶
动物实验配方

Tags: Terazosin hydrochloride dihydrate | Terazosin HCl Dihydrate | 盐酸特拉唑嗪 二水合物 | Adrenergic Receptor | AmBeed-信号通路专用抑制剂 | Terazosin hydrochloride dihydrate 纯度/质量文件 | Terazosin hydrochloride dihydrate 亚型比较 | Terazosin hydrochloride dihydrate 生物活性 | Terazosin hydrochloride dihydrate 临床数据 | Terazosin hydrochloride dihydrate 参考文献 | Terazosin hydrochloride dihydrate 实验方案 | Terazosin hydrochloride dihydrate 技术信息

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