SU11274 | c-Met/HGFR Inhibitor | AmBeed-信号通路专用抑制剂

首页 / / / / SU11274

SU11274 99%+

货号：A597744 同义名： PKI-SU11274;Met Kinase Inhibitor

SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.

SU11274 化学结构
CAS号：658084-23-2

SU11274 3D分子结构
CAS号：658084-23-2

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

SU11274 纯度/质量文件产品仅供科研

货号：A597744 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

自噬亚型比较
DNA甲基转移酶亚型比较

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK1, IC50: 108 nM ULK2, IC50: 711 nM		97%
Hydroxychloroquine sulfate	✔		99%
Valproic acid sodium	✔	HDAC	97%
PFK-015	++ PFKFB3, IC50: 207 nM		99%+
MRT68921 hydrochloride	++++ ULK1, IC50: 2.9 nM ULK2, IC50: 1.1 nM		99%+
ROC-325	✔		99%+
Autophinib	+++ Autophagy, IC50: 40 nM		99%+
Lys05	✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	DNA Methyltransferase ↓ ↑	纯度
6-Thioguanine	✔	99%+
Zebularine	✔	99%+
Procainamide hydrochloride	✔	99%
5-Azacytidine	✔	99%+
Decitabine	✔	99%
SGI-1027	++ DNMT1, IC50: 6 μM DNMT3A, IC50: 7.5 μM	99%+
RG108	+++ DNA methyltransferase, IC50: 115 nM	99%+
Guadecitabine sodium	✔	99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

SU11274 生物活性

描述	SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.

SU11274 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
A549 cells		Function assay		Inhibition of human recombinant c-MET kinase in A549 cells assessed as inhibition of HGF-induced cell growth, IC50=0.01 μM	21812414
DLD1 cells	2.5 μM	Function assay		Inhibition of human p38-alpha phosphorylation in DLD1 cells at 2.5 μM	17595299
DLD1 cells	2.5 μM	Function assay	16 h	Inhibition of human MET receptor in DLD1 cells at 2.5 uM after 16 hrs by Western blot	17595299
human BxPC3 cells		Proliferation assay	72 h	Antiproliferative activity against human BxPC3 cells after 72 hrs	21405128

SU11274 参考文献

[1]Wang X, Le P, et al. Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Mol Cancer Ther. 2003 Nov;2(11):1085-92.

[2]Sattler M, Pride YB, et al. A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 2003 Sep 1;63(17):5462-9.

SU11274 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.80mL

1.76mL

0.88mL

17.60mL

3.52mL

1.76mL

SU11274 技术信息

CAS号	658084-23-2
分子式	C₂₈H₃₀ClN₅O₄S
分子量	568.087

别名	PKI-SU11274;Met Kinase Inhibitor
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(184.83 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

A549 cells		Function assay		Inhibition of human recombinant c-MET kinase in A549 cells assessed as inhibition of HGF-induced cell growth, IC50=0.01 μM	21812414
DLD1 cells	2.5 μM	Function assay		Inhibition of human p38-alpha phosphorylation in DLD1 cells at 2.5 μM	17595299
DLD1 cells	2.5 μM	Function assay	16 h	Inhibition of human MET receptor in DLD1 cells at 2.5 uM after 16 hrs by Western blot	17595299
human BxPC3 cells		Proliferation assay	72 h	Antiproliferative activity against human BxPC3 cells after 72 hrs	21405128
human HepG2 cells		Function assay		Inhibition of Met-mediated tumorigenesis in HGF-stimulated human HepG2 cells assessed as impairment in anchorage-independent growth by soft agar growth assay, IC50=1.561 μM	22138308
human MCF7 cells		Proliferation assay	72 h	Antiproliferative activity against human MCF7 cells after 72 hrs, IC50=6.2 μM	21405128
human MDA-MB-231 cells		Proliferation assay	72 h	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs	21405128
human MDCK cells		Function assay	24 h	Inhibition of Met-mediated scattering in HGF-stimulated human MDCK cells pre-incubated overnight prior to HGF stimulation for 24 hrs measured after 24 to 48 hrs, IC50=0.152 μM	22138308
human MKN45 cells		Proliferation assay	72 h	Antiproliferative activity against human MKN45 cells after 72 hrs, IC50=1.3 μM	21405128
human NCI-H1993 cells		Proliferation assay	72 h	Antiproliferative activity against human NCI-H1993 cells after 72 hrs, IC50=7.3 μM	21405128
human NCI-H441 cells		Proliferation assay	72 h	Antiproliferative activity against human NCI-H441 cells after 72 hrs	21405128
human SNU1 cells		Proliferation assay	72 h	Antiproliferative activity against human SNU1 cells after 72 hrs, IC50=7 μM	21405128
human SNU5 cells		Proliferation assay	72 h	Antiproliferative activity against human SNU5 cells after 72 hrs, IC50=0.8 μM	21405128
mouse BAF3 cells		Proliferation assay	72 h	Antiproliferative activity against mouse BAF3 cells expressing TPR-Met after 72 hrs in absence of IL-3, IC50=0.53 μM	21405128
mouse NIH/3T3 cells		Proliferation assay	72 h	Antiproliferative activity against mouse NIH/3T3 cells expressing TPR-Met after 72 hrs, IC50=2 μM	21405128

SU11274 99%+

SU11274 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

SU11274 质控信息

SU11274 生物活性

SU11274 细胞研究

SU11274 参考文献

SU11274 实验方案

SU11274 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

SU11274 99%+

SU11274 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

SU11274 质控信息

SU11274 生物活性

SU11274 细胞研究

SU11274 参考文献

SU11274 实验方案

SU11274 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

SU11274 纯度/质量文件产品仅供科研