SW155246是一种选择性的 DNA 甲基转移酶 (DNMT1) 抑制剂，IC₅₀ 值为 1.2 μM (hDNMT1) 和 38 μM (mDNMT3A)。该化合物可用于癌症和表观遗传学疾病的研究，具有显著的表观遗传调节作用。

GSK-3685032是一种非时间依赖性、非共价、可逆的DNMT1选择性抑制剂，IC50为0.036 μM。GSK-3685032诱导DNA去甲基化、转录激活和抑制癌细胞生长。

GSK3735967是一种选择性、可逆的非核苷类 DNMT1 抑制剂，含有平面二氰基吡啶核心，可特异性嵌入 DNMT1 结合的半甲基化 CpG 双核苷酸中。GSK3735967 具有三个结合位点，其中之一能与组蛋白 H4K20me3 结合。

γ-Oryzanol is a phytochemical with membrane antioxidant, naturally occurring in crude rice bran oil, can be used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.

SGI-1027 是一种DNA甲基转移酶（DNMT）抑制剂，使用poly(dI-dC)作为底物，其对DNMT3B、DNMT3A和DNMT1的IC50值分别为7.5 μM、8 μM和12.5 μM。

DC_05 is a non-nucleoside DNMT1 inhibitor (IC50=10.3 μM) with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.

Lomeguatrib, an inhibitor of DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) with IC50 of 0.009 μM in cell-free extracts from HeLa S3 cells, is a modified guanine base.

5−Fluoro−2'−deoxycytidine is a DNMT inhibitor which forms covalent links with the cysteine residue in the DNMT active site.

Decitabine is a potent inhibitor of DNA methyltransferase with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively.

6-Thioguanine belongs to the thiopurine family of drugs that also include mercaptopurine and azathioprine, which are examples of antimetabolites, and is a purine analogue of the nucleobase guanine. It was found to inhibit SARS-CoV PLpro. 6-Thioguanine disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.

SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.

RG108 is a DNA methyltransferase inhibitor with IC50 of 115 nM.

Bobcat339 HCl 是一种有效的选择性胞嘧啶TET酶抑制剂，对TET1和TET2的IC50值分别为33μM和73μM。它在表观遗传学领域很有价值，是针对DNA甲基化和基因转录的新疗法的基础。

CM-272 is a potent, selective and reversible dual small molecule against G9a and DNMTs activity.

Zebularine is a DNA methylation inhibitor which forms a covalent complex with DNA methyltransferases, it also inhibits cytidinedeaminase with Ki of 2 μM.

2′,3′,5′-Triacetyl-5-azacytidine是一种口服活性的前体，能够抑制DNA甲基转移酶，展示出对肿瘤细胞的潜在抑制作用。

(-)-Epigallocatechin Gallate 是绿茶中的主要多酚，能抑制细胞增殖并诱导细胞凋亡，抑制谷氨酸脱氢酶 1/2 (GDH1/2, GLUD1/2) 活性，具有抗癌、抗氧化和抗炎特性。

GSK-3484862 是 DNA 甲基转移酶 DNMT1 的非共价抑制剂，通过诱导 DNA 低甲基化起抗癌作用。

5-Azacytidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.