SU11274

产品说明书

Print
Chemical Structure| 658084-23-2 同义名 : PKI-SU11274;Met Kinase Inhibitor
CAS号 : 658084-23-2
货号 : A597744
分子式 : C28H30ClN5O4S
纯度 : 99%+
分子量 : 568.087
MDL号 : MFCD08276928
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(184.83 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SU11274 is a selective Met inhibitor with IC50 of 10 nM, no effects on PGDFRβ, EGFR or Tie2.
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
A549 cells Function assay Inhibition of human recombinant c-MET kinase in A549 cells assessed as inhibition of HGF-induced cell growth, IC50=0.01 μM 21812414
DLD1 cells 2.5 μM Function assay Inhibition of human p38-alpha phosphorylation in DLD1 cells at 2.5 μM 17595299
DLD1 cells 2.5 μM Function assay 16 h Inhibition of human MET receptor in DLD1 cells at 2.5 uM after 16 hrs by Western blot 17595299
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.80mL

1.76mL

0.88mL

17.60mL

3.52mL

1.76mL
参考文献

[1]Wang X, Le P, et al. Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Mol Cancer Ther. 2003 Nov;2(11):1085-92.

[2]Sattler M, Pride YB, et al. A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 2003 Sep 1;63(17):5462-9.