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快速发货 顺丰冷链运输,1-2 天到达
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技术支持
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产品名称 | Akt ↓ ↑ | Akt1 ↓ ↑ | Akt2 ↓ ↑ | Akt3 ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Honokiol | ✔ | MEK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
PF-04691502 |
++++
P-Akt (T308), IC50: 7.5 nM P-Akt (S473), IC50: 3.8 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
PHT-427 |
+
Akt, Ki: 2.7 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Deguelin | ✔ | PI3K | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
TIC10 isomer | ✔ | ERK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Perifosine |
+
Akt, IC50: 4.7 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Miltefosine | ✔ | PI3K,PKC | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Triciribine |
+
Akt, IC50: 130 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Uprosertib |
+
Akt1, IC50: 180 nM |
+
Akt2, IC50: 328 nM |
++
Akt3, IC50: 38 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Afuresertib |
++++
Akt1, Ki: 0.08 nM |
++++
Akt2, Ki: 2 nM |
++++
Akt3, Ki: 2.6 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Miransertib |
++++
Akt1, IC50: 5 nM |
++++
Akt2, IC50: 4.5 nM |
++
Akt3, IC50: 16 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
GSK-690693 |
++++
Akt1, IC50: 2 nM |
+++
Akt2, IC50: 13 nM |
+++
Akt3, IC50: 9 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
AT7867 |
++
Akt1, IC50: 32 nM |
++
Akt2, IC50: 17 nM |
++
Akt3, IC50: 47 nM |
PKA | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
AKT inhibitor VIII |
++
Akt1, IC50: 58 nM |
+
Akt2, IC50: 210 nM |
+
Akt3, IC50: 2119 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
MK-2206 2HCl |
+++
Akt1, IC50: 8 nM |
+++
Akt2, IC50: 12 nM |
+
Akt3, IC50: 65 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Ipatasertib |
++++
Akt1, IC50: 5 nM |
++
Akt2, IC50: 18 nM |
+++
Akt3, IC50: 8 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
AT13148 |
++
Akt1, IC50: 38 nM |
+
Akt2, IC50: 402 nM |
++
Akt3, IC50: 50 nM |
PKA | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
Capivasertib |
++++
Akt1, IC50: 3 nM |
+++
Akt2, IC50: 8 nM |
+++
Akt3, IC50: 8 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
A-674563 HCl |
+++
Akt1, Ki: 11 nM |
PKA | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
CCT128930 |
+++
Akt2, IC50: 6 nM |
PKA | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | C2β ↓ ↑ | p110α ↓ ↑ | p110β ↓ ↑ | p110γ ↓ ↑ | p110δ ↓ ↑ | PI3K ↓ ↑ | Vps34 ↓ ↑ | 其他靶点 | 纯度 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A66 |
+
C2β, IC50: 462 nM |
++
p110α, IC50: 32 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Taselisib |
+
C2β, IC50: 292 nM |
++++
PI3Kα, Ki: 0.29 nM |
+++
PI3Kβ, Ki: 9.1 nM |
++++
PI3Kγ, Ki: 0.97 nM |
++++
PI3Kδ, Ki: 0.12 nM |
+
hVps34, IC50: 374 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||
Gedatolisib |
++++
PI3Kα, IC50: 0.4 nM |
+++
PI3Kγ, IC50: 5.4 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||||
HS-173 |
++++
PI3Kα , IC50: 0.8 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Serabelisib |
+++
PI3Kα, IC50: 21 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
GNE-477 |
++++
PI3Kα, IC50: 4 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
YM-201636 |
+
p110α, IC50: 3.3 μM |
PIKfyve | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
AS-252424 |
+
PI3Kα, IC50: 935 nM |
++
PI3Kγ, IC50: 33 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Alpelisib |
+++
PI3Kα, IC50: 5 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
AS-604850 |
+
PI3Kα, IC50: 4.5 μM |
+
PI3Kγ, IC50: 0.25 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
SF2523 |
++
PI3Kα, IC50: 34 nM |
++
PI3Kγ, IC50: 158 nM |
mTOR,DNA-PK | {[allProObj[0].p_purity_real_show]} | |||||||||||||||
Inavolisib |
++++
PI3K alpha, IC50: 0.038 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Bimiralisib |
++++
PI3Kα, Kd: 1.5 nM |
+++
PI3Kβ, Kd: 11 nM |
++
PI3Kγ, Kd: 25 nM |
++
PI3Kδ, Kd: 25 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||
GSK1059615 |
++++
PI3Kα, IC50: 0.4 nM |
++++
PI3Kβ, IC50: 0.6 nM |
+++
PI3Kγ, IC50: 5 nM |
++++
PI3Kδ, IC50: 2 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||
GSK2636771 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Fimepinostat |
+++
PI3Kα, IC50: 19 nM |
++
PI3Kβ, IC50: 54 nM |
++
PI3Kδ, IC50: 39 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
VS-5584 |
++++
PI3Kα, IC50: 2.6 nM |
+++
PI3Kβ, IC50: 21 nM |
++++
PI3Kγ, IC50: 3.0 nM |
++++
PI3Kδ, IC50: 2.7 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||
Dactolisib |
++++
p110α1, IC50: 4 nM |
++
p110β, IC50: 75 nM |
+++
p110γ, IC50: 5 nM |
+++
p110δ, IC50: 7 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
PI-103 |
++++
p110α, IC50: 2 nM |
++++
p110β, IC50: 3 nM |
+++
p110γ, IC50: 15 nM |
++++
p110δ, IC50: 3 nM |
mTOR,DNA-PK | {[allProObj[0].p_purity_real_show]} | |||||||||||||
PI-3065 |
+
p110β, IC50: 1078 nM |
+++
p110δ, IC50: 15 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Voxtalisib |
++
PI3Kα, IC50: 39 nM |
++
PI3Kβ, IC50: 113 nM |
+++
PI3Kγ, IC50: 9 nM |
++
PI3Kδ, IC50: 43 nM |
mTOR,DNA-PK | {[allProObj[0].p_purity_real_show]} | |||||||||||||
AZD-8835 |
+++
PI3Kα, IC50: 6.2 nM |
+
PI3Kβ, IC50: 431 nM |
++
PI3Kγ, IC50: 90 nM |
+++
PI3Kδ, IC50: 5.7 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
Pilaralisib analogue |
++
PI3Kα, IC50: 39 nM |
++
PI3Kβ, IC50: 36 nM |
+++
PI3Kγ, IC50: 23 nM |
++
PI3Kδ, IC50: 36 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
ZSTK474 |
+++
PI3Kα, IC50: 16 nM |
++
PI3Kβ, IC50: 44 nM |
++
PI3Kγ, IC50: 49 nM |
+++
PI3Kδ, IC50: 4.6 nM |
++
PI3K, IC50: 37 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||
AS-605240 |
++
PI3Kα, IC50: 60 nM |
+
PI3Kβ, IC50: 270 nM |
+++
PI3Kγ, IC50: 8 nM |
+
PI3Kδ, IC50: 300 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
TGX-221 |
+++
p110β, IC50: 5 nM |
++
p110δ, IC50: 0.1 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
PF-04691502 |
++++
PI3Kα, Ki: 1.8 nM |
++++
PI3Kβ, Ki: 2.1 nM |
++++
PI3Kγ, Ki: 1.9 nM |
++++
PI3Kδ, Ki: 1.6 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||
GDC-0084 |
++++
PI3Kα, Ki app: 2 nM |
++
PI3Kβ, Ki app: 46 nM |
+++
PI3Kγ, Ki app: 10 nM |
++++
PI3Kδ, Ki app: 3 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||
Buparlisib |
++
p110α, IC50: 52 nM |
+
p110β, IC50: 166 nM |
+
p110γ, IC50: 262 nM |
++
p110δ, IC50: 116 nM |
+
Vps34, IC50: 2.4 μM |
mTOR | {[allProObj[0].p_purity_real_show]} | ||||||||||||
LY294002 |
+
p110α, IC50: 0.5 μM |
+
p110β, IC50: 0.97 μM |
+
p110δ, IC50: 0.57 μM |
DNA-PK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
AZD 6482 |
+
PI3Kα, IC50: 870 nM |
+++
PI3Kβ, IC50: 10 nM |
++
PI3Kδ, IC50: 80 nM |
DNA-PK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
Pictilisib |
++++
p110α, IC50: 3 nM |
++
p110β, IC50: 33 nM |
++
p110γ, IC50: 75 nM |
++++
p110δ, IC50: 3 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||
PKI-402 |
++++
PI3Kα, IC50: 2 nM |
+++
PI3Kβ, IC50: 7 nM |
+++
PI3Kγ, IC50: 16 nM |
+++
PI3Kδ, IC50: 14 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||
Copanlisib |
++++
PI3Kα, IC50: 0.5 nM |
++++
PI3Kβ, IC50: 3.7 nM |
+++
PI3Kγ, IC50: 6.4 nM |
++++
PI3Kδ, IC50: 0.7 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
Omipalisib |
++++
p110α, Ki: 0.019 nM |
++++
p110β, Ki: 0.13 nM |
++++
p110γ, Ki: 0.06 nM |
++++
p110δ, Ki: 0.024 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
Izorlisib |
+++
PI3Kα, IC50: 14 nM |
++
PI3Kβ, IC50: 0.12 μM |
++
PI3Kγ, IC50: 36 nM |
+
PI3Kδ, IC50: 0.50 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
AZD8186 |
++
PI3Kα, IC50: 35 nM |
++++
PI3Kβ, IC50: 4 nM |
+++
PI3Kδ, IC50: 12 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
KU-0060648 |
++++
PI3Kα, IC50: 4 nM |
++++
PI3Kβ, IC50: 0.5 nM |
+
PI3Kγ, IC50: 0.59 μM |
++++
PI3Kδ, IC50: 0.1 nM |
DNA-PK | {[allProObj[0].p_purity_real_show]} | |||||||||||||
Apitolisib |
+++
p110α, IC50: 5 nM |
++
p110β, IC50: 27 nM |
+++
p110γ, IC50: 14 nM |
+++
p110δ, IC50: 7 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | |||||||||||||
CZC24832 |
+
PI3Kβ, IC50: 1.1 μM |
++
PI3Kγ, IC50: 27 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
BGT226 maleate |
++++
PI3Kα, IC50: 4 nM |
++
PI3Kβ, IC50: 63 nM |
++
PI3Kγ, IC50: 38 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
TG 100713 |
++
PI3Kα, IC50: 165 nM |
+
PI3Kβ, IC50: 215 nM |
++
PI3Kγ, IC50: 50 nM |
+++
PI3Kδ, IC50: 24 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
PI3K-IN-1 |
++
PI3Kα, IC50: 39 nM |
++
PI3Kβ, IC50: 113 nM |
+++
PI3Kγ, IC50: 9 nM |
++
PI3Kδ, IC50: 43 nM |
mTOR,DNA-PK | {[allProObj[0].p_purity_real_show]} | |||||||||||||
TG100-115 |
+
PI3Kα, IC50: 1.3 μM |
+
PI3Kβ, IC50: 1.2 μM |
++
PI3Kγ, IC50: 83 nM |
+
PI3Kδ, IC50: 235 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
PIK-90 |
+++
PI3Kα, IC50: 11 nM |
+
PI3Kβ, IC50: 350 nM |
+++
PI3Kγ, IC50: 18 nM |
++
PI3Kδ, IC50: 58 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
PIK-294 |
+
p110β, IC50: 490 nM |
++
p110γ, IC50: 160 nM |
+++
p110δ, IC50: 10 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Duvelisib |
++++
PI3Kβ, Ki: 1564 pM |
++
PI3Kγ, Ki: 243 pM |
++++
PI3Kδ, Ki: 23 pM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
GDC-0326 |
++++
PI3Kα, Ki: 0.2 nM |
++
PI3Kβ, Ki: 26.6 nM |
+++
PI3Kγ, Ki: 10.2 nM |
++++
PI3Kδ, Ki: 4 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
Quercetin Dihydrate |
+
PI3Kβ, IC50: 5.4 μM |
+
PI3Kγ, IC50: 2.4 μM |
+
PI3Kδ, IC50: 3.0 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Quercetin |
+
PI3Kβ, IC50: 5.4 μM |
+
PI3Kγ, IC50: 2.4 μM |
+
PI3Kδ, IC50: 3.0 μM |
Src,Sirtuin,PKC | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
Leniolisib |
+
PI3Kα, IC50: 0.244 μM |
+
PI3Kβ, IC50: 0.424 μM |
+
PI3Kγ, IC50: 2.23 μM |
+++
PI3Kδ, IC50: 0.011 μM |
DNA-PK | {[allProObj[0].p_purity_real_show]} | |||||||||||||
PIK-108 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Eganelisib |
+++
PI3Kγ, IC50: 16 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
CAY10505 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
IPI-3063 |
++++
p110δ, IC50: 2.5 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nemiralisib |
++++
PI3Kδ, pKi: 9.9 |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
PF-4989216 |
++++
p110α, IC50: 2 nM |
++
p110γ, IC50: 65 nM |
++++
p110δ, IC50: 1 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
PIK-75 HCl |
+++
p110α, IC50: 5.8 nM |
++
p110γ, IC50: 76 nM |
+
p110δ, IC50: 0.51 μM |
DNA-PK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
Tenalisib |
++
PI3Kγ, IC50: 33.2 nM |
++
PI3Kδ, IC50: 24.5 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Acalisib |
+++
p110δ, IC50: 14 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Umbralisib |
+++
PI3Kδ, IC50: 22.2 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
AMG319 |
+
PI3Kγ, IC50: 850 nM |
+++
PI3Kδ, IC50: 18 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
IC-87114 |
+
PI3Kγ, IC50: 29 μM |
+
PI3Kδ, IC50: 0.5 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Idelalisib |
++
p110γ, IC50: 89 nM |
++++
p110δ, IC50: 2.5 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
PIK-293 |
+
p110γ, IC50: 10 μM |
+
p110δ, IC50: 0.24 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Vps34-PIK-III |
+
PI3Kδ, IC50: 1.2μM |
+++
Vps34, IC50: 0.018μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
GSK2292767 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Seletalisib |
+
PI3Kγ, IC50: 282 nM |
+++
PI3Kδ, IC50: 12 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
P110δ-IN-1 |
++++
P110δ, IC50: 0.6 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
PI3Kδ-IN-5 |
++++
PI3Kδ, IC50: 0.9 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SRX3207 |
+
PI3K alpha, IC50: 244 nM |
+
PI3K gamma, IC50: 9790 nM |
+
PI3K delta, IC50: 388 nM |
Syk | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
Parsaclisib HCl |
++++
PI3Kδ, IC50: 1 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
IHMT-PI3Kδ-372 |
+++
PI3Kδ, IC50: 14 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Trigonelline | ✔ | Akt | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Wortmannin |
++++
PI3K, IC50: 3 nM |
MLCK,DNA-PK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Samotolisib | ✔ | DNA-PK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
GNE-317 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Oroxin B | ✔ | Akt,PTEN | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
NU 7026 |
+
PI3K, IC50: 13 μM |
DNA-PK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Deguelin | ✔ | Akt | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Ailanthone | ✔ | Akt,CDK,ATM/ATR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Resibufogenin | ✔ | ROS | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
KU-57788 |
+
PI3K, IC50: 5 μM |
mTOR,DNA-PK | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Cinobufagine | ✔ | Akt | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
α-Linolenic acid | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
MTX-211 | ✔ | EGFR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
PI3K/mTOR Inhibitor-2 |
++++
PI3K, IC50: 3.4 nM |
mTOR | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
SPP-86 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
(E)-Akt inhibitor-IV | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Vps34-IN-1 |
++
Vps34, IC50: 25 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SAR405 |
++++
Vps34, IC50: 1.2 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
3-Methyladenine |
+
PI3Kγ, IC50: 60 μM |
+
Vps34, IC50: 25 μM |
Autophagy | {[allProObj[0].p_purity_real_show]} | |||||||||||||||
Vps34-IN-4 |
+++
VPS34, IC50: 15 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Autophinib |
+++
Vps34, IC50: 19 nM |
Autophagy | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Recilisib, also known as ON 01210, is a radioprotective agent that activates AKT and PI3K activity in cells. Recilisib (up to 50 μM) shows a normal distribution of cells throughout the cell cycle, with a slight reduction in S phase cells at 50 μM. Continuous exposure to Recilisib (100 μM) does not lead to cell death. Treatment with Recilisib does not inhibit the colony-forming potential of human bone marrow cells. Recilisib provides dose-dependent protection to human bone marrow cells under all three doses of IR. It activates the phosphorylation of AKT and GSK3α/β in HFL cells. Recilisib increases the response of HFL-1 cells and mouse bone marrow cells to radiation exposure, thereby increasing PI3K activity. Treatment with Recilisib in combination with radiation therapy alters the MAPK signaling pathway[1]. |
Animal study | At dosage of 500 mg/kg, Recilisib significantly enhances the recovery and differentiation rate of primitive murine bone marrow myeloid progenitor cells. When combined with radiation therapy, Recilisib reduces the number of CFUs in mice, yet mice treated with Recilisib always retain the capacity to form differentiated colonies. The progenitor cell population in mice treated with Recilisib will never be completely depleted due to radiation exposure[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.97mL 0.59mL 0.30mL |
14.85mL 2.97mL 1.48mL |
29.69mL 5.94mL 2.97mL |
CAS号 | 334969-03-8 |
分子式 | C16H13ClO4S |
分子量 | 336.79 |
别名 | ON 01210;EX-RAD |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 35 mg/mL(103.92 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |