美托咪定 /Medetomidine
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货号：A102119
Medetomidine is an agonist of α2-adrenoceptor with Ki value of 1.08 nM, used as both a surgical anesthetic and analgesic.
Medetomidine 化学结构
Medetomidine 3D分子结构
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价格
会员价
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Medetomidine 纯度/质量文件 产品仅供科研
货号：A102119
标准纯度：
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Medetomidine 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
98%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2B-adrenergic receptor, pKi: 8.9
α2A-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2A, pKi: 7.1
adrenoceptor α2C, pKi: 7.2
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1D-adrenergic receptor, Ki: 20 nM
α1A-adrenergic receptor, Ki: 3.7 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
97%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
98%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Medetomidine 生物活性
描述
Medetomidine is an alpha2-adrenergic receptor agonist and is used clinically in veterinary medicine to produce sedation and analgesia, with Ki values of 1.08 and 1750 nM for α2- and α1-adrenoceptors, respectively. Due to its lipophilic structure, medetomidine is rapidly absorbed after intramuscular administration and reaches peak plasma concentrations in approximately 0.5h[3] In vivo research suggests that medetomidine has many beneficial effects in anesthesia practice, including reliable sedation, analgesia, muscle relaxation, and anxiolysis[4]
Medetomidine 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT01524367
Agitation
Phase 4
Completed
-
Korea, Republic of
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Gangnam severance hospital
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Medetomidine 参考文献
[1] Wenger S, Hoby S, et al. Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride. Vet Anaesth Analg. 2013 Mar;40(2):176-80.
[2] Kallio A, Koulu M, et al. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5.
[3] Lamont LA, Burton SA, Caines D, Troncy ED. Effects of 2 different infusion rates of medetomidine on sedation score, cardiopulmonary parameters, and serum levels of medetomidine in healthy dogs. Can J Vet Res. 2012 Oct;76(4):308-16. PMID: 23543957; PMCID: PMC3460610.
[4] Pawela CP, Biswal BB, Hudetz AG, Schulte ML, Li R, Jones SR, Cho YR, Matloub HS, Hyde JS. A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity. Neuroimage. 2009 Jul 15;46(4):1137-47. doi: 10.1016/j.neuroimage.2009.03.004. Epub 2009 Mar 12. PMID: 19285560; PMCID: PMC2693293.
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Medetomidine 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.99mL
1.00mL
0.50mL
24.97mL
4.99mL
2.50mL
49.93mL
9.99mL
4.99mL
Medetomidine 技术信息
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