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Medetomidine

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Chemical Structure| 86347-14-0 同义名 : -
CAS号 : 86347-14-0
货号 : A102119
分子式 : C13H16N2
纯度 : 99+%
分子量 : 200.28
MDL号 : MFCD00864346
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1248.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Medetomidine is an alpha2-adrenergic receptor agonist and is used clinically in veterinary medicine to produce sedation and analgesia, with Ki values of 1.08 and 1750 nM for α2- and α1-adrenoceptors, respectively. Due to its lipophilic structure, medetomidine is rapidly absorbed after intramuscular administration and reaches peak plasma concentrations in approximately 0.5h[3]. In vivo research suggests that medetomidine has many beneficial effects in anesthesia practice, including reliable sedation, analgesia, muscle relaxation, and anxiolysis[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01524367 Agitation Phase 4 Completed - Korea, Republic of ... 展开 >> Gangnam severance hospital Seoul, Korea, Republic of 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.99mL

1.00mL

0.50mL

24.97mL

4.99mL

2.50mL

49.93mL

9.99mL

4.99mL
参考文献

[1]Wenger S, Hoby S, et al. Anaesthesia with medetomidine, midazolam and ketamine in six gorillas after premedication with oral zuclopenthixol dihydrochloride. Vet Anaesth Analg. 2013 Mar;40(2):176-80.

[2]Kallio A, Koulu M, et al. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5.

[3]Lamont LA, Burton SA, Caines D, Troncy ED. Effects of 2 different infusion rates of medetomidine on sedation score, cardiopulmonary parameters, and serum levels of medetomidine in healthy dogs. Can J Vet Res. 2012 Oct;76(4):308-16. PMID: 23543957; PMCID: PMC3460610.

[4]Pawela CP, Biswal BB, Hudetz AG, Schulte ML, Li R, Jones SR, Cho YR, Matloub HS, Hyde JS. A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity. Neuroimage. 2009 Jul 15;46(4):1137-47. doi: 10.1016/j.neuroimage.2009.03.004. Epub 2009 Mar 12. PMID: 19285560; PMCID: PMC2693293.